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Thomas Lenarz - Biomedical Technology

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Thomas Lenarz Biomedical Technology
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    Biomedical Technology
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Springer International Publishing Switzerland 2015
Thomas Lenarz and Peter Wriggers (eds.) Biomedical Technology Lecture Notes in Applied and Computational Mechanics 10.1007/978-3-319-10981-7_1
RVE Procedure for Estimating the Elastic Properties of Inhomogeneous Microstructures Such as Bone Tissue
Tanja Bl 1
(1)
Institute for Mechanical Engineering and Computer-Assisted Product Development, Helmut Schmidt University/Bundeswehr University, Hamburg, Germany
Tanja Bl (Corresponding author)
Email:
Michael Welsch
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Abstract
Cancellous bone can roughly be seen as a two-phase material consisting of the bone tissue reinforcement and the interstitial bone marrow matrix. Thus, for a computer-aided mechanical stress analysis of bones a constitutive law is required, which can predict the inhomogeneous elasticity depending on the local bone density and microstructure. Besides several measurement methods, the method of representative volume element (RVE) in combination with the finite element solution technique has been established for this purpose. This work investigates this method in detail. Therefore, random but statistical equivalent RVEs are created to have unlimited access to different structures. Generally, an apparent and not an effective stiffness is obtained due to the RVE method. However, a very close solution can be achieved if several issues are considered carefully. These issues can be divided into the set of boundary conditions, the RVE size and averaging the randomness. The influences are investigated accurately. A new approach is proposed to deduce an isotropic constitutive law from the anisotropic stiffness matrix. There are unlimited possible solutions in theory. However, the Voigt and Reuss approximations give the possible bounds. A method is described, which allows to obtain the effective stiffness by merging these bounds. A structural analysis is performed with different RVEs and the effective stiffness is estimated for varying parameters. An empirical equation is introduced, which covers the whole stiffness range. Therein, the microstructure is modelled with a single parameter. Real bone measurements can be fitted with this equation as well.
Keywords
Cancellous bone Boundary conditions Elastic properties FEM Homogenization Voigt and Reuss approximation
Introduction
Computer simulations become more and more important for endoprosthetic investigations of bones. Therefore, a realistic material modeling is required to ensure a reliable prediction of the inner mechanical stresses. Bones generally consist of cancellous bone surrounded by a thin layer of dense compact bone resulting in location-dependent material properties. The modelling of the microstructure in detail is computational out of reach nowadays. A pointwise homogenization of the stochastic and heterogeneous microstructure would be beneficial. Thus, a constitutive law is required that can predict the inhomogeneous elasticity depending on the local bone density and microstructure.
Direct mechanical measurements for example are performed by Ashmann et al.[]. Different issues raise by dealing with the continuum mechanics approach. Ulrich et al. investigated the influence of meshing and element formulation. Pahr and Zysset compared several sets of boundary conditions regarding the accuracy of the obtained stiffness of human cancellous bone specimens.
Since the procedure of calculating the anisotropic stiffness matrix seems to be clear, it lacks of estimating a corresponding isotropic constitutive law. The theory of micromechanics and homogenization points out to distinguish between apparent and effective estimates. As a general rule, an apparent estimate is obtained since the window size is limited. However, a convergence study allows the prediction of an effective estimate by increasing the window size stepwise (cp. Kanit []).
Notwithstanding that the FEM solution is an approximation by nature, an apparent estimate should be expected generally due to use of boundary conditions.
This work presents a study of the different influences and proposes a procedure to calculate effective moduli. Methods are presented to determine the effectiveness of the solution. Plenty different, but stochastically equivalent structures are needed to study the influences entirely. An algorithm is applied to generate an unlimited number of varying representative volume elements (RVE).
Material and Method
2.1 Generation of Stochastic RVE
Cancellous bone can roughly be seen as a two-phase material consisting of the bone tissue reinforcement and the interstitial bone marrow matrix. Generally, the effective elastic properties of such materials are depending on the respective volume fractions, the elastic properties of both materials and the structural composition.
A simple algorithm generates random RVE structures in three steps. First an initial number of cells are randomly assigned with material within a three-dimensional grid. Afterwards additional cells are randomly selected, but only assigned with material, if they are adjacent to existing material. This is done until a given volume fraction is reached. In a final step, all remaining grid cells are assigned with the matrix material. This algorithm is illustrated in Fig..
Fig 1 Illustration of the RVE generating algorithm Material is agglomerated - photo 1
Fig. 1
Illustration of the RVE generating algorithm. Material is agglomerated randomly around existing material
While the volume fraction is directly regulated, the RVE structure develops indirectly by the number of initial cells. A rather rough cluster with high material agglomerations emerges from a small number of initial cells, whereas a fine dispersed cluster emerges from many initial cells. Figure shows three different RVEs, each with 50 elements per edge and equal volume fraction but varying number of initial cells.
Biomedical Technology - image 2
Fig. 2
Agglomerated material of different structures is emerged from varying number of initial cells. Left 0.00625 %, middle 0.2 % and right 6.4 % initial cells, all with 25 % volume fraction in a grid of Biomedical Technology - image 3
2.2 Continuum Mechanics Approach
The continuum mechanics approach is used to calculate three-dimensional material deformations. For static considerations the momentum balance of the current configuration is reduced to a time and mass invariant equilibrium that can be expressed by the divergence of the Cauchy stress tensor.
Picture 4
(1)
This expression is under-constrained and additional definitions are required. First of all, the continuity of the field quantities is postulated, meaning that all deformations are physically objective and infinitesimal small material particles are not allowed to penetrate each other or fluctuate. This uniqueness is obtained by the definition of the deformation tensor.
Biomedical Technology - image 5
(2)
In terms of the physical objectivity, the material behavior of elastic bodies (also denoted as Cauchy elasticity) now demand tensor compatibility of stress and deformation.
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