Calogero Caruso - Human Aging: From Cellular Mechanisms to Therapeutic Strategies

Academic Press is an imprint of Elsevier

125 London Wall, London EC2Y 5AS, United Kingdom

525 B Street, Suite 1650, San Diego, CA 92101, United States

50 Hampshire Street, 5th Floor, Cambridge, MA 02139, United States

The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, United Kingdom

Copyright 2021 Elsevier Inc. All rights reserved.

No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publishers permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions.

This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).

Notices

Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.

Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.

To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.

Library of Congress Cataloging-in-Publication Data

A catalog record for this book is available from the Library of Congress

British Library Cataloguing-in-Publication Data

A catalogue record for this book is available from the British Library

ISBN 978-0-12-822569-1

For information on all Academic Press publications visit our website at https://www.elsevier.com/books-and-journals

Publisher: Wolff, Andre Gerhard

Editorial Project Manager: Ashdown, Megan

Production Project Manager: Raviraj, Selvaraj

Cover Designer: Hitchen, Miles

Typeset by SPi Global, India

Giulia Accardi Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy

Anna Aiello Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy

Sara De Biasi Department of Medical and Surgical Sciences of Children and Adults, University of Modena and Reggio Emilia, Modena, Italy

Filippa Bono Department of Economics, Business and Statistics, University of Palermo, Palermo, Italy

Ewa Bryl Department of Pathology and Experimental Rheumatology, Medical University of Gdansk, Gdansk, Poland

Annalisa Busetta Department of Economics, Business and Statistics, University of Palermo, Palermo, Italy

Edward Calabrese Department of Environmental Health Sciences, University of Massachusetts, Amherst, MA, United States

Vittorio Calabrese Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Catania, Italy

Giuseppina Candore Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy

Ciriaco Carru Department of Biomedical Sciences, University of Sassari, Hospital University (AOUSS), Sassari, Italy

Calogero Caruso Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy

Arrrgo F.G. Cicero

Medical and Surgery Sciences Department, Alma Mater Studiorum University of Bologna

Italian Nutraceutical Society (SINut), Bologna, Italy

Alessandro Colletti

Italian Nutraceutical Society (SINut), Bologna

Pharmacology Department, University of Turin, Turin, Italy

Christopher P. Coplen Department of Immunobiology, University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ, United States

Andrea Cossarizza Department of Medical and Surgical Sciences of Children and Adults, University of Modena and Reggio Emilia, Modena, Italy

Lucia Crax Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D.), Section of Pathology, University of Palermo, Palermo, Italy

Paolina Crocco Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy

Serena Dato Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy

Sergio Davinelli Department of Medicine and Health Sciences V. Tiberio, University of Molise, Campobasso, Italy

Lucia Fidanza Department of Medical and Surgical Sciences of Children and Adults, University of Modena and Reggio Emilia, Modena, Italy

Tamas Fulop Department of medicine, Research Center on Aging, Graduate Program in Immunology, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, QC, Canada

Anna De Gaetano Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy

Damiano Galimberti Italian Association of Anti-Ageing Physicians, Milano, Italy

Lara Gibellini Department of Medical and Surgical Sciences of Children and Adults, University of Modena and Reggio Emilia, Modena, Italy

Francesca Iannone Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy

Mladen Jergovi Department of Immunobiology, University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ, United States

Mattia Emanuela Ligotti Laboratory of Immunopathology and Immunosenescence, Department of Biomedicine, Neurosciences and Advanced Diagnostics, University of Palermo, Palermo, Italy

Domenico Lo Tartaro Department of Medical and Surgical Sciences of Children and Adults, University of Modena and Reggio Emilia, Modena, Italy

Marco Mattioli Department of Medical and Surgical Sciences of Children and Adults, University of Modena and Reggio Emilia, Modena, Italy

Giuseppe Mazzola Italian Association of Anti-Ageing Physicians, Milano, Italy

Milena Nasi Department of Surgery, Medicine, Dentistry and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy

Janko Nikolich-ugich Department of Immunobiology, University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ, United States

Fabiola Olivieri

Department of Clinical and Molecular Sciences, DISCLIMO, Universit Politecnica delle Marche

Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy

Maria Laura Ontario Department of Biomedical and Biotechnological Sciences, School of Medicine, University of Catania, Catania, Italy

Giuseppe Passarino Department of Biology, Ecology and Earth Sciences, University of Calabria, Rende, Italy