Jim E. Riviere - Veterinary Pharmacology and Therapeutics

Tenth Edition

Tenth Edition

Jim E. Riviere, DVM, PhD, DSc (hon) and Mark G. Papich, DVM, MS

This edition first published 2018
2018 John Wiley & Sons, Inc. (except chapters 5, 51, 53, 55 and 58 which are in the public domain)

Edition History
John Wiley and Sons, Inc. (9e, 2009); Iowa State University Press, a Blackwell Publishing company (8e, 2001; 7e, 1995; 6e, 1988; 5e, 1982; 4e, 1977; 3e, 1965; 2e, 1957; 1e, 1954)

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording or otherwise, except as permitted by law. Advice on how to obtain permission to reuse material from this title is available at http://www.wiley.com/go/permissions.

The right of Jim E. Riviere and Mark G. Papich to be identified as the authors of the editorial material in this work has been asserted in accordance with law.

Registered Offices
John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA

Editorial Office
John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030, USA

For details of our global editorial offices, customer services, and more information about Wiley products visit us at www.wiley.com.

Wiley also publishes its books in a variety of electronic formats and by print-on-demand. Some content that appears in standard print versions of this book may not be available in other formats.

Limit of Liability/Disclaimer of Warranty
The contents of this work are intended to further general scientific research, understanding, and discussion only and are not intended and should not be relied upon as recommending or promoting scientific method, diagnosis, or treatment by physicians for any particular patient. The publisher and the authors make no representations or warranties with respect to the accuracy and completeness of the contents of this work and specifically disclaim all warranties, including without limitation any implied warranties of fitness for a particular purpose. In view of ongoing research, equipment modifications, changes in governmental regulations, and the constant flow of information relating to the use of medicines, equipment, and devices, the reader is urged to review and evaluate the information provided in the package insert or instructions for each medicine, equipment, or device for, among other things, any changes in the instructions or indication of usage and for added warnings and precautions. Readers should consult with a specialist where appropriate. The fact that an organization or website is referred to in this work as a citation and/or potential source of further information does not mean that the author or the publisher endorses the information the organization or website may provide or recommendations it may make. Further, readers should be aware that websites listed in this work may have changed or disappeared between when this works was written and when it is read. No warranty may be created or extended by any promotional statements for this work. Neither the publisher nor the author shall be liable for any damages arising herefrom.

Library of Congress Cataloging-in-Publication Data

Names: Riviere, J. Edmond (Jim Edmond), editor. | Papich, Mark G., editor.
Title: Veterinary pharmacology and therapeutics / edited by Jim E. Riviere,
Mark G. Papich.
Description: Tenth edition. | Hoboken, NJ : John Wiley & Sons Inc., 2018. |
Includes bibliographical references and index.
Identifiers: LCCN 2016055348| ISBN 9781118855829 (cloth) | ISBN 9781118855775 (Adobe PDF) |
ISBN 9781118855881 (epub)
Subjects: LCSH: Veterinary pharmacology. | MESH: Drug Therapyveterinary |
Veterinary Drugspharmacology
Classification: LCC SF915 .V49 2017 | NLM SF 915 | DDC 636.089/51--dc23 LC
record available at https://lccn.loc.gov/2016055348

Cover Design and Images: Courtesy of Mal Rooks Hoover, CMI

In loving memory of my son Dr. Brian A. Riviere.

Luis I. Alvarez

Laboratorio de Farmacolgia,

Facultad de Ciencias Veterinaries,

Universidad Nacional del Centro,

Departamento de Centro de Investigacion Veterinaria,

Campus Universitario (7000),

Tandil, Argentina

Marisa K. Ames

College of Veterinary Medicine,

Colorado State University,

Fort Collins, CO 80523

Michael D. Apley

Department of Clinical Sciences,

College of Veterinary Medicine,

Mosier Hall Q-218,

Kansas State University,

Manhattan, KS 66506

Marjory A. Artzer

Department of Clinical Sciences,

College of Veterinary Medicine,

Kansas State University,

Manhattan, KS 66506

Clarke E. Atkins

College of Veterinary Medicine,

North Carolina State University,

Raleigh, NC 27606

C. Scott Bailey

Department of Clinical Sciences,

College of Veterinary Medicine,

North Carolina State University,

1060 William Moore Drive,

Raleigh, NC 27607

John D. Baker

FDA Center for Veterinary Medicine,

Office of Surveillance and Compliance,

Division of Veterinary Product Safety,

7519 Standish Place Rockville, MD 20855

Wolfgang Bumer

Institute of Pharmacology and Toxicology,

Faculty of Veterinary Medicine,

Free University Berlin,

Koserstrae 20, 14195 Berlin

Ronald E. Baynes

Department of Population Health & Pathobiology,

Center for Chemical Toxicology Research and Pharmacokinetics,

College of Veterinary Medicine,

North Carolina State University,

1060 William Moore Drive,

Raleigh, NC 27607

Susan J. Bright-Ponte

FDA Center for Veterinary Medicine,

Office of Surveillance and Compliance,

Division of Veterinary Product Safety,

7519 Standish Place Rockville, MD 20855

Robert J. Brosnan

Department of Surgical and Radiological Sciences,

School of Veterinary Medicine,

University of California,

Davis, CA 95616

Alison Clode

InTown Veterinary Group

Port City Veterinary Referral Hospital

215 Commerce Way

Portsmouth, NH 03801

Cynthia A. Cole

IDEXX Pharmaceutical, Inc,

7009 Albert Pick Road,

Greensboro, NC 27409

Gigi Davidson

VTH Pharmacy,

College of Veterinary Medicine,

North Carolina State University,

1060 William Moore Drive,

Raleigh, NC 27607

Elizabeth G. Davis

Department of Clinical Sciences,

College of Veterinary Medicine,

Kansas State University,

Manhattan, KS 66506

Jennifer L. Davis

Department of Biomedical Sciences & Pathobiology,

VA-MD College of Veterinary Medicine,

205 Duck Pond Drive,

Blacksburg, VA 24061

Raafat M. Fahmy

Center for Veterinary Medicine,

U.S. Food and Drug Administration,

7500 Standish Place,

Rockville, MD 20855

Duncan C. Ferguson

Department of Comparative Biosciences,

College of Veterinary Medicine,

University of Illinois at Urbana-Champaign,

2001 S. Lincoln Avenue,

Urbana, IL 61802

Daniel A. Frese

Department of Diagnostic Medicine Pathobiology,

College of Veterinary Medicine,

Kansas State University,

Manhattan, KS 66506

John Gadsby

Department of Molecular Biomedical Sciences,

College of Veterinary Medicine

Next page