Robert Wilkins - Oxford Handbook of Medical Sciences
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OXFORD MEDICAL PUBLICATIONS
Oxford Handbook of
Medical Sciences
Published and forthcoming Oxford Medical Handbooks
Oxford Handbook for the Foundation Programme 3e
Oxford Handbook of Acute Medicine 3e
Oxford Handbook of Anaesthesia 3e
Oxford Handbook of Applied Dental Sciences
Oxford Handbook of Cardiology
Oxford Handbook of Clinical and Laboratory Investigation 2e
Oxford Handbook of Clinical Dentistry 5e
Oxford Handbook of Clinical Diagnosis 2e
Oxford Handbook of Clinical Examination and Practical Skills
Oxford Handbook of Clinical Haematology 3e
Oxford Handbook of Clinical Immunology and Allergy 2e
Oxford Handbook of Clinical Medicine - Mini Edition 8e
Oxford Handbook of Clinical Medicine 8e
Oxford Handbook of Clinical Pharmacy
Oxford Handbook of Clinical Rehabilitation 2e
Oxford Handbook of Clinical Specialties 8e
Oxford Handbook of Clinical Surgery 3e
Oxford Handbook of Complementary Medicine
Oxford Handbook of Critical Care 3e
Oxford Handbook of Dental Patient Care 2e
Oxford Handbook of Dialysis 3e
Oxford Handbook of Emergency Medicine 3e
Oxford Handbook of Endocrinology and Diabetes 2e
Oxford Handbook of ENT and Head and Neck Surgery
Oxford Handbook of Expedition and Wilderness Medicine
Oxford Handbook of Gastroenterology & Hepatology
Oxford Handbook of General Practice 3e
Oxford Handbook of Genetics
Oxford Handbook of Genitourinary Medicine, HIV and AIDS 2e
Oxford Handbook of Geriatric Medicine
Oxford Handbook of Infectious Diseases and Microbiology
Oxford Handbook of Key Clinical Evidence
Oxford Handbook of Medical Dermatology
Oxford Handbook of Medical Sciences 2e
Oxford Handbook of Medical Statistics
Oxford Handbook of Nephrology and Hypertension
Oxford Handbook of Neurology
Oxford Handbook of Nutrition and Dietetics 2e
Oxford Handbook of Obstetrics and Gynaecology 2e
Oxford Handbook of Occupational Health
Oxford Handbook of Oncology 3e
Oxford Handbook of Ophthalmology 2e
Oxford Handbook of Paediatrics
Oxford Handbook of Pain Management
Oxford Handbook of Palliative Care 2e
Oxford Handbook of Practical Drug Therapy 2e
Oxford Handbook of Pre-Hospital Care
Oxford Handbook of Psychiatry 2e
Oxford Handbook of Public Health Practice 2e
Oxford Handbook of Reproductive Medicine & Family Planning
Oxford Handbook of Respiratory Medicine 2e
Oxford Handbook of Rheumatology 2e
Oxford Handbook of Sport and Exercise Medicine
Oxford Handbook of Tropical Medicine 3e
Oxford Handbook of Urology 2e
Second edition
Edited by
Dr Robert Wilkins
University Lecturer in Physiology,
University of Oxford;
American Fellow in Physiology,
St Edmund Hall, Oxford
Dr Simon Cross
Reader and Honorary Consultant,
Academic Unit of Pathology,
Department of Neuroscience,
School of Medicine, Dentistry & Health,
University of Sheffield, UK
Prof Ian Megson
Head, Department of Diabetes & Cardiovascular Science
University of the Highlands and Islands,
Inverness, UK
Dr David Meredith
Senior Lecturer in Biochemistry & Biomedical Science,
Oxford Brookes University,
Oxford, UK
Great Clarendon Street, Oxford OX2 6DP
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Oxford is a registered trade mark of Oxford University Press
in the UK and in certain other countries
Published in the United States
by Oxford University Press Inc., New York
Oxford University Press, 2011, except pp172181 section of
Chapter 2 ( Keith Frayn)
First edition published 2006
Reprinted 2008 (with corrections), 2009
Second edition published 2011
Reprinted 2013, 2015, 2016, 2017, 2018, 2019
The moral rights of the author have been asserted
Database right Oxford University Press (maker)
All rights reserved. No part of this publication may be reproduced,
stored in a retrieval system, or transmitted, in any form or by any means,
without the prior permission in writing of Oxford University Press,
or as expressly permitted by law, or under terms agreed with the appropriate
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Oxford University Press, at the address above
You must not circulate this book in any other binding or cover
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British Library Cataloguing in Publication Data
Data available
Library of Congress Cataloging in Publication Data
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Typeset by Glyph International, Bangalore, India
Printed in China
on acid-free paper by
C&C Offset Printing Co. Ltd
ISBN 9780199588442
10 9 8 6 5 4 3 2 1
Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up-to-date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work. Except where otherwise stated, drug dosages and recommendations are for the non-pregnant adult who is not breastfeeding.
This Handbook is written by Biomedical Scientists and Clinicians to disseminate the fundamental scientific principles that underpin clinical medicine. Frequent cross-referencing with the Oxford Handbook of Clinical Medicine helps to highlight the clinical relevance of specific issues. The challenge of this ambitious undertaking was to distil the contents of information found in several voluminous textbooks into a conveniently-sized handbook, without loss of important information. This has been achieved by sifting out the key facts that are crucial to understanding fundamental principles and presenting them as clear, brief statements or straightforward diagrams. The Handbook has been deliberately divided into sections that mirror modern medical teaching strategies; it builds from a clear, easily digestible account of basic cell physiology and biochemistry to an investigation of the traditional piers of medicine (anatomy, physiology, biochemistry, pathology, and pharmacology), intertwined in the context of each of the major systems relevant to the human body. Although primarily aimed at medical students, this Handbook will also provide a useful reference for science students studying any of the traditional biomedical sciences.
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