John Laszlo - The Cure of Childhood Leukemia: Into the Age of Miracles
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The Cure of Childhood Leukemia: Into the Age of Miracles
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John Laszlo, M.D. National Vice President for Research American Cancer Society
Rutgers University Press New Brunswick, New Jersey
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Library of Congress Cataloging-in-Publication Data
Laszlo, John, 1931 The cure of childhood leukemia: into the age of miracles / John Laszlo. p. cm. Includes bibliographical references and index. ISBN 0-8135-2186-6 1. Leukemia in children-Research-History. 2. Leukemia in children-Treatment-History. 1. Title. RJ416.L4L38 1995 618.92'9941906-dc2094-47285 CIP
British Cataloging-in-Publication information available
Copyright 1995 by John Laszlo Published by Rutgers University Press, New Brunswick, New Jersey All rights reserved Manufactured in the United States of America
Dedicated to the thousands of families and the hundreds of scientists who were united by a common goal-to eliminate leukemia as a dread disease
Page vii
Contents
Preface
ix
PROLOGUE
1
PART I A Disease of Despair
Maria
7
CHAPTER 1 The Discovery of Leukemia
11
CHAPTER 2 Plans without Blueprints
22
PART II The Pioneers
CHAPTER 3 Donald Pinkel, M.D.: Beginnings
35
CHAPTER 4 Joseph Burchenal, M.D.
45
CHAPTER 5 George H. Hitchings, Ph.D.
62
CHAPTER 6 Gertrude B. Elion, Ph.D. (Hon.)
80
PART III The Hub
NCI
89
CHAPTER 7 C. Gordon Zubrod, M.D.
93
CHAPTER 8 Emil J Freireich, M.D.
108
CHAPTER 9 Emil (Tom) Frei III, M.D.
156
The Blood Cell Separator
190
PART IV The Periphery
CHAPTER 10 Howard Earle Skipper, Ph.D.
199
CHAPTER 11 James Holland, M.D.
210
CHAPTER 12 Donald Pinkel, M.D.: Culmination
230
Page viii
PART V The Lucky Ones
Debbie Brown
241
James Eversull
244
Charlotte Boozer and Her Parents
248
Clay Johnson
253
Leslie Willig
260
EPILOGUE: A Disease with Hope
267
Bibliography
273
Index
279
Page ix
Preface
The cure for childhood leukemia is a singular event in the history of medicine. Singular because it proves that cancer can be cured, a significant achievement that opens the way to victory over the many other faces of the disease. Singular too because of the way the cure emerged. In our society, it is often only the final result, the bottom line, that captures attention. So let it be told that, with childhood leukemia, there was no such thing as the discovery of a curerather there was the brilliant assembly of a series of small, endlessly persevering steps forward that led to success. This book is about how it happened, who did it, and why they kept on trying.
The history of the cure of childhood leukemia is so recent that we do not need to reconstruct or extrapolate from scattered records. Most of the physicians and scientists who did the major work are still alive. So are many of their patientsthe best testimonial to the success of the endeavor. Their recollections serve as the chief, rich source for telling this story.
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