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Robert D. Martin - Subarachnoid Hemorrhage: Neurological Care and Protection

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Robert D. Martin Subarachnoid Hemorrhage: Neurological Care and Protection

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This book highlights the latest developments in acute and delayed neurovascular injury studies including delayed cerebral vasospasm, early brain injury, micro-circulation compromise, spreading cortical depolarization, neuroinflammation, and long-term cognitive dysfunctions after subarachnoid hemorrhage. About 32 chapters cover original presentations from the 14th international conference on neurovascular events after subarachnoid hemorrhage, held in Los Angeles in October 2017. Neurosurgeons, neurologists, and neuro-ICU practitioners discuss clinical observations, new pilot treatments, clinical trials, academic and industrial interactions, including surgical and endovascular approaches, brain injury monitoring, new developments in brain imaging, ICU management, early brain injury scales and management, counter cortical depolarization management and anti-inflammation management. In addition, animal models used to study acute and delayed neurovascular events, the basic mechanisms of vascular, neuronal, and CSF physiology, new experimental treatment strategies, new frontiers in the treatment of neurovascular injuries, and new research directions are discussed.

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Volume 127 Acta Neurochirurgica Supplement Series Editor H-J Steiger For - photo 1
Volume 127
Acta Neurochirurgica Supplement
Series Editor
H.-J. Steiger

For further volumes: http://www.springer.com/series/4

Editors
Robert D. Martin , Warren Boling , Gang Chen and John H. Zhang
Subarachnoid Hemorrhage Neurological Care and Protection
Editors Robert D Martin Department of Anethesiology Loma Linda University - photo 2
Editors
Robert D. Martin
Department of Anethesiology, Loma Linda University Medical Center, Loma Linda, CA, USA
Warren Boling
Department of Neurosurgery, Loma Linda University Medical Center, Loma Linda, CA, USA
Gang Chen
Department of Neurosurgery, First Affiliated Hospital of Soochow University, Suzhou, China
John H. Zhang
Department of Anesthesiology and Physiology, Loma Linda University Medical Center, Loma Linda, CA, USA
ISSN 0065-1419 e-ISSN 2197-8395
Acta Neurochirurgica Supplement
ISBN 978-3-030-04614-9 e-ISBN 978-3-030-04615-6
https://doi.org/10.1007/978-3-030-04615-6
Springer Nature Switzerland AG 2020
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This Springer imprint is published by the registered company Springer Nature Switzerland AG

The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Preface

It has been a long, winding, and mysterious way to get here.

The former, current, and future leaders have met at the 14th International Conference on Neurovascular Events after Subarachnoid Hemorrhage or Vasospasm 2017 at the beautiful Pacific Ocean Huntington Beach invited here by Prof. John Zhang to his neck of the woods (Loma Linda University Health) to discuss Subarachnoid Hemorrhage: Neurological Care and Protection.

It has been a long time since the first meeting in Jackson, Mississippi, in 1972 and even longer from not always civilized public arguments among neurology and neurosurgery giants about the existence and the role of delayed vasospasm on the outcome of an aneurismal rupture. Fortunately, those altercations were peacefully settled by Bryce Weirs (this meeting Honorary Guest) seminal paper published in 1978, which through linking the presence of delayed vasospasm with poor outcome had opened the door to the intensive all-over-the-world research and led to organizing the international meetings, which since then have been taking place on three continents at the different time intervals and which have been devoted to the still-evolving ideas on pathomechanism, prevention, and treatment of vasospasm after aneurismal SAH.

A little bit nostalgic, at the 14th International Conference on Neurovascular Events after Subarachnoid Hemorrhage or Vasospasm 2017 at the Huntington Beach Resort, CA, 176 registrants from 14 countries (with an encouraging and importantly an increasing number of women participants (29; 17%)) gathered to present and discuss their past, current, and future research and share the experiences and anecdotes about the late and current leaders in the field and their thoughts and opinions about past mistakes and successes while dealing with an aneurismal subarachnoid hemorrhage and its effects on patients.

This book consists of 31 excellent papers selected from 167 oral and poster presentations exploring known knowns, known unknowns, as well as some unknown unknowns in many fields integrated into preclinical and clinical research of events leading to and evoked by an aneurismal subarachnoid hemorrhage. Put together, they provide in-depth inside view of the current state of our knowledge and understanding of events before and after intracranial subarachnoid hemorrhage and indicate the new directions in our long pursuit of prevention and treatment of a devastating, despite being treatable, intracranial aneurism rupture. We strongly believe that those proceedings not only will help the young basic and clinical researchers to accrue good foundations for understanding pathomechanism(s) of subarachnoid hemorrhage and vasospasm(s?) to proceed and/or develop their own ideas and projects but also will facilitate opening of multipronged venues for further research.

We thank Dr. John Lenart, Ms. Shirley Jones, Ms. Sheila Risley, and Ms. Kathrine McAllister from the Department of Anesthesiology and Ms. Olivia Portugal and Ms. Xiomara Pineda from the Department of Neurosurgery for putting in an immense amount of time to set up all aspects of the meeting. The foundation they laid made this symposium possible. The last but not by any means the least, our gratitude is extended to all members of the Organizing Committee; Dr. Robert D. Martin, Chair of the Department of Anesthesiology, and Dr. Warren Boling, Chair of the Department of Neurosurgery of Loma Linda University Health; medical companies; and above all the participants !

Thank you and see you at the 15th Symposium at the Netherlands in 2019!

From the Organizing Committee

Ryszard M. Pluta
John H. Zhang
Loma Linda, CA, USA
Contents
Bryce Weir
Kenji Kanamaru
Nicolas K. Khattar , Esther Bak , Andrew C. White and Robert F. James
Warren Boling and Lydia Kore
Part IBasic Science Section
Alejandra N. Martinez , Crissey L. Pascale , Peter S. Amenta , Rachel Israilevich and Aaron S. Dumont
Tomohiro Aoki , Haruka Miyata , Yu Abekura , Hirokazu Koseki and Kampei Shimizu
Fumi Nakano , Lei Liu , Fumihiro Kawakita , Yoshinari Nakatsuka , Hirofumi Nishikawa , Takeshi Okada , Masato Shiba and Hidenori Suzuki
Jinjin Wang , Yin Liu , Haitao Shen , Haiying Li , Zhong Wang and Gang Chen
Fumi Nakano , Fumihiro Kawakita , Lei Liu , Yoshinari Nakatsuka , Hirofumi Nishikawa , Takeshi Okada , Masato Shiba and Hidenori Suzuki
E. Liu , Linlin Sun , Yixuan Zhang , Aibo Wang and Junhao Yan
Hirofumi Nishikawa , Fumi Nakano , Lei Liu , Yoshinari Nakatsuka , Takeshi Okada , Masato Shiba and Hidenori Suzuki
Yuchun Zuo , Tibiao He , Peiqiang Liao , Kai Zhuang , Xiaoxin Yan and Fei Liu
Takeshi Okada , Liu Lei , Hirofumi Nishikawa , Fumi Nakano , Yoshinari Nakatsuka and Hidenori Suzuki
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