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Institute of Medicien - IMMUNIZATION SAFETY REVIEW: THIMEROSAL-CONTAINING VACCINES AND NEURODEVELOPMENTAL DISORDERS

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IMMUNIZATION SAFETY REVIEW

THIMEROSAL-CONTAINING VACCINES AND NEURODEVELOPMENTAL DISORDERS

Kathleen Stratton, Alicia Gable, and Marie C.McCormick, Editors

Immunization Safety Review Committee

Board on Health Promotion and Disease Prevention

INSTITUTE OF MEDICINE

NATIONAL ACADEMY PRESS

Washington, D.C.

NATIONAL ACADEMY PRESS
2101 Constitution Avenue, N.W.
Washington, DC20418

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

Support for this project was provided by the Centers for Disease Control and Prevention and the National Institute of Allergy and Infectious Diseases of the National Institutes of Health as part of a National Institutes of Health Task Order No. 74. The views presented in this report are those of the Institute of Medicine Immunization Safety Review Committee and are not necessarily those of the funding agencies.

ISBN 0-309-17037-0 e-pub ISBN

International Standard Book Number0-309-07636-6

Additional copies of this report are available for sale from the National Academy Press, 2101 Constitution Avenue, N.W., Box 285, Washington, DC 20055. Call 800624 6242 or (202) 3343313 (in the Washington metropolitan area), or visit the NAPs home page at
www.nap.edu.

For more information about the Institute of Medicine, visit the IOM home page at . For more information regarding this report and other reports to be issued by this committee, visit the IOM project web page at .

Copyright 2001 by the National Academy of Sciences. All rights reserved.
Printed in the United States of America.

The serpent has been a symbol of long life, healing, and knowledge among almost all cultures and religions since the beginning of recorded history. The serpent adopted as a logotype by the Institute of Medicine is a relief carving from ancient Greece, now held by the Staatliche Museen in Berlin.

THE NATIONAL ACADEMIES

National Academy of Sciences

National Academy of Engineering

Institute of Medicine

National Research Council

The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Bruce M.Alberts is president of the National Academy of Sciences.

The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. Wm.A.Wulf is president of the National Academy of Engineering.

The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Kenneth I.Shine is president of the Institute of Medicine.

The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academys purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Bruce M.Alberts and Dr. Wm.A.Wulf are chairman and vice chairman, respectively, of the National Research Council.

IMMUNIZATION SAFETY REVIEW COMMITTEE

MARIE C.McCORMICK, M.D., Sc.D.,(Chair), Professor and Chair,

Department of Maternal and Child Health, Harvard School of Public Health

RONALD BAYER, Ph.D., Professor,

Division of Sociomedical Sciences, School of Public Health, Columbia University

ALFRED BERG, M.D., M.P.H., Professor and Chair,

Department of Family Medicine, University of Washington School of Medicine

ROSEMARY CASEY, M.D., Associate Professor of Pediatrics,

Jefferson Medical College and

Director,

Lankenau Faculty Pediatrics, Wynnewood, Pennsylvania

JOSHUA COHEN, Ph.D., Senior Research Associate,

Harvard Center for Risk Analysis, Harvard School of Public Health

CONSTANTINE GATSONIS, Ph.D., Professor of Medical Science and Applied Math, and Director,

Center for Statistical Sciences, Brown University

MICHAEL KABACK, M.D., Professor,

Pediatrics and Reproductive Medicine, University of California, San Diego

GERALD MEDOFF, M.D., Professor,

Department of Internal Medicine, Washington University School of Medicine, St. Louis

REBECCA PARKIN, Ph.D., Associate Research Professor,

Department of Occupational and Environmental Health, School of Public Health and Health Services, George Washington University

BENNETT SHAYWITZ, M.D., Professor of Pediatrics and Neurology, Co-Director,

Yale Center for the Study of Learning and Attention

CHRISTOPHER WILSON, M.D., Professor and Chair,

Department of Immunology, University of Washington

The following individuals are members of the Immunization Safety Review Committee but were unable to attend the meeting on the topic of this report:

VERNICE DAVIS-ANTHONY, M.P.H., Senior Vice President,

Corporate Affairs and Community Health, St. John Health System, Detroit, Michigan

BETSY FOXMAN, Ph.D., Professor,

Department of Epidemiology, School of Public Health, University of Michigan

STEVEN GOODMAN, M.D., M.H.S., Ph.D., Associate Professor,

Department of Oncology, Division of Biostatistics, Johns Hopkins School of Medicine

ELLEN HORAK, M.S.N., Chief of Local Services,

Office of Local and Rural Health, Kansas Department of Health and Environment

Health Promotion and Disease Prevention Board Liaison

RICHARD B.JOHNSTON, Jr., M.D., Professor of Pediatrics,

Department of Pediatrics, University of Colorado School of Medicine and National Jewish Medical and Research Center

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