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Table of Contents
Copyright

HIV/AIDS: Global Status - 2018 edition
Stephen Berger, MD
Copyright 2018 by GIDEON Informatics, Inc. All rights reserved.
Published by GIDEON Informatics, Inc, Los Angeles, California, USA. www.gideononline.com
Cover design by GIDEON Informatics, Inc
No part of this book may be reproduced or transmitted in any form or by any means without written permission from the publisher. Contact GIDEON Informatics at .
ISBN: 978-1-4988-2016-5
Visit www.gideononline.com/ebooks/ for the up to date list of GIDEON ebooks.
DISCLAIMER
Publisher assumes no liability to patients with respect to the actions of physicians, health care facilities and other users, and is not responsible for any injury, death or damage resulting from the use, misuse or interpretation of information obtained through this book. Therapeutic options listed are limited to published studies and reviews. Therapy should not be undertaken without a thorough assessment of the indications, contraindications and side effects of any prospective drug or intervention. Furthermore, the data for the book are largely derived from incidence and prevalence statistics whose accuracy will vary widely for individual diseases and countries. Changes in endemicity, incidence, and drugs of choice may occur. The list of drugs, infectious diseases and even country names will vary with time.
Scope of Content
Disease designations may reflect a specific pathogen (ie, Adenovirus infection), generic pathology (Pneumonia - bacterial) or etiologic grouping (Coltiviruses - Old world). Such classification reflects the clinical approach to disease allocation in the Infectious Diseases Module of the GIDEON web application. Similarly, a number of diseases which are generally diagnosed and treated outside of the field of Infectious Diseases are not included, despite the fact that a clear infectious etiology exists. Examples include Peptic ulcer, Creutzfeldt-Jakob disease, Human papillomavirus infections, etc. In contrast, a number of other entities of unknown etiology which do present to Infectious Diseases specialists have been included: Kawasaki's disease, Chronic fatigue syndrome, Kikuchi and Kimura diseases. Several minor infections having minimal relevance to the field of Infectious Diseases are not covered: Paronychia, Otitis externa, etc.
Introduction: The GIDEON e-book series
HIV/AIDS: Global Status is one in a series of GIDEON ebooks which summarize the status of Infectious diseases, Drugs, Vaccines and Pathogens - in every country of the world.
The ebook includes:
1. Descriptive epidemiology
2. Clinical features
3. Distribution map
4. Images
5. Global status and status in every relevant country
6. References
The initial items in the first section, Descriptive epidemiology, are definedas follows:
AgentClassification (e.g., virus, parasite) and taxonomic designation.
ReservoirAny animal, arthropod, plant, soil or substance in which aninfectious agent normally lives andmultiplies, on which it depends primarily for survival, and where it reproducesitself in such a manner that it canbe transmitted to a susceptible host.
VectorAn arthropod or other living carrier which transports an infectiousagent from an infected organism orreservoir to a susceptible individual or immediate surroundings.
VehicleThe mode of transmission for an infectious agent. This generallyimplies a passive and inanimate (i.e.,non-vector) mode.

Scope
There are 357 generic infectious diseases in the world today. Many of these are universally distributed, with little published data regarding their status inspecific countries. Although other diseases are not endemic to given countries, data have been reported concerning imported infection, acquisition by expatriates or othercontext. All such literature will be included.
Content
Data are based on the GIDEON web application (www.gideononline.com) whichrelies on standard text books, peer-review journals, Health Ministry reportsand ProMED, supplemented by an ongoing search of the medical literature.
The availability and quality of literature regarding specific infectiousdiseases vary from country to country. As such, you may find that many of thesections in this book are limited to a general discussion of the diseaseitself, with data regarding only a few countries.
This is a book about the geography and epidemiology of Infection.Comprehensive and up-to-date information regarding the causes, diagnosis andtreatment of each disease is available in the GIDEON web application. Many of the diseases are generic. For example, such designations as Viral meningitis and Equine encephalitis include a number of individual diseases.These appear under the subheading, Synonyms, listed after each disease.
Exploring Outbreaks and Surveys
Outbreak and survey charts are designed to allow users to quickly scan and compare publications according to year, setting, number of cases / deaths, affected population and other parameters. Linked references are displayed where available.
Parallel charts in the GIDEON web app allow for sorting within columns. In the following example, data are displayed alphabetically by outbreak setting or region.
We welcome feedback and will be pleased to add any relevant sourced material - photo 1
We welcome feedback, and will be pleased to add any relevant, sourced material. Email us at
For more information about GIDEON see the section
Last updated: May 17, 2018
HIV/AIDS
Epidemiology
Agent
VIRUS - RNA.
Retroviridae, Lentivirinae: Human Immunodeficiency Virus, HIV
Reservoir
Human
Vector
None
Vehicle
Blood, Semen, Sexual, Transplacental, Breastfeeding
Incubation Period
2m - 10y (50% within 10y)
Diagnostic Tests
HIV antibody (ELISA, Western blot).
Nucleic acid amplification.
Tests for HIV antigen & viral load as indicated.
Typical Adult Therapy
Nucleoside/-nucleotide reverse transcriptase inhibitor +
A Non-nucleoside reverse transcriptase inhibitor
OR a Protease Inhibitor
OR a Strand-transfer integrase inhibitor
Typical Pediatric Therapy
Regimens vary - in general:
2 Non-nucleoside reverse transcriptase inhibitors +
Ritonavir / Lopinavir
OR Nevirapine
OR Atazanavir
Vaccine
Ibalizumab
Clinical Hints
- Most often associated with drug abuse, blood products, men who have sex with men, hemophilia
- Severe and multiple episodes of infection (herpes simplex, moniliasis, candidiasis, etc)
- Chronic cough, diarrhea, weight loss, lymphadenopathy, retinitis, encephalitis or Kaposi's sarcoma
Synonyms
AIDS,ARC,Gay cancer,GRID,HIV-1,HIV-2,HIV-AIDS,SIDA,Slim disease.
ICD9: 042
ICD10: B20,B21,B22,B23,B24

Clinical

CDC case surveillance definition:
As of 1993, the CDC (The United States Centers for Disease Control) surveillance case definition for AIDS includes all HIV-infected persons age 13 or over who have either.
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