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Juan Bueno - Preclinical Evaluation of Antimicrobial Nanodrugs

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Juan Bueno Preclinical Evaluation of Antimicrobial Nanodrugs
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Nanotechnology in the Life Sciences Series Editor Ram Prasad Department of - photo 1
Nanotechnology in the Life Sciences
Series Editor
Ram Prasad
Department of Botany, Mahatma Gandhi Central University, Motihari, Bihar, India

Nano and biotechnology are two of the 21st centurys most promising technologies. Nanotechnology is demarcated as the design, development, and application of materials and devices whose least functional make up is on a nanometer scale (1 to 100 nm). Meanwhile, biotechnology deals with metabolic and other physiological developments of biological subjects including microorganisms. These microbial processes have opened up new opportunities to explore novel applications, for example, the biosynthesis of metal nanomaterials, with the implication that these two technologies (i.e., thus nanobiotechnology) can play a vital role in developing and executing many valuable tools in the study of life. Nanotechnology is very diverse, ranging from extensions of conventional device physics to completely new approaches based upon molecular self-assembly, from developing new materials with dimensions on the nanoscale, to investigating whether we can directly control matters on/in the atomic scale level. This idea entails its application to diverse fields of science such as plant biology, organic chemistry, agriculture, the food industry, and more.

Nanobiotechnology offers a wide range of uses in medicine, agriculture, and the environment. Many diseases that do not have cures today may be cured by nanotechnology in the future. Use of nanotechnology in medical therapeutics needs adequate evaluation of its risk and safety factors. Scientists who are against the use of nanotechnology also agree that advancement in nanotechnology should continue because this field promises great benefits, but testing should be carried out to ensure its safety in people. It is possible that nanomedicine in the future will play a crucial role in the treatment of human and plant diseases, and also in the enhancement of normal human physiology and plant systems, respectively. If everything proceeds as expected, nanobiotechnology will, one day, become an inevitable part of our everyday life and will help save many lives.

More information about this series at http://www.springer.com/series/15921

Juan Bueno
Preclinical Evaluation of Antimicrobial Nanodrugs
Juan Bueno Senior Researcher Research Center of Bioprospecting and - photo 2
Juan Bueno
Senior Researcher, Research Center of Bioprospecting and Biotechnology for Biodiversity Foundation (BIOLABB), Armenia, Quindio, Colombia
ISSN 2523-8027 e-ISSN 2523-8035
Nanotechnology in the Life Sciences
ISBN 978-3-030-43854-8 e-ISBN 978-3-030-43855-5
https://doi.org/10.1007/978-3-030-43855-5
Springer Nature Switzerland AG 2020
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This Springer imprint is published by the registered company Springer Nature Switzerland AG

The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Dedication

Dedicated to

Martha Ritor for her full support and management for the realization of this book

Sebastian Ritor for his constant work to improve on the road that awaits us

ITC Ritor for her eternal and unconditional company during the writing of this manuscript

Here we stand, bound forevermore

Were out of this world, until the end

Here we are, mighty, glorious

At The End Of The Rainbow

With gold in our hands

Andreas Mueck/Joacim Anders Cans, Martin Albrecht-Lindow

End of the Rainbow by Hammerfall, Legacy of Kings

Preface
We are facing one of the biggest threats in public health and perhaps one of the biggest medical crises in human history. Resistance to antimicrobial drugs is progressively increasing without a blunt response to their control and treatment. This lack of a scientific and political response puts all communities at risk of being affected by the emergence of new resistant microorganisms as well as the acquisition of resistance mechanisms by those that were already believed to be controlled, taking also into consideration the possibility of a global transmission due to the increase in transoceanic travel. Thus, in this order of ideas, a revolutionary innovation is required in the design and development of new antimicrobial drugs that allow greater action within the framework of a personalized medicine and avoid the emergence of resistance with low toxicity in patients affected by infectious diseases. In this way, nanotechnology represents this advance of impact in the advent of a modern anti-infective pharmacology. Thus, it is possible using this technology to obtain new formulations with nanocarrier s and develop new antibiotics combined with nanoparticle s and nanostructure design that scientists can produce both nanosurfaces and antimicrobial nanocoating s capable of reducing the transmission of infectious disease from pandemic outbreaks. But it is also important to remember that in a modern symbiotic medicine where the holobiont (host and its symbiotes), the following guidelines should be taken into account for the development of new antimicrobials :
  • Anti-infectives should have the highest possible affinity for the target microorganism.

  • They should have pharmacokinetic and pharmacodynamic parameters capable of being adapted to the pharmacogenetic aspects of the patient in a personalized medicine model.

  • They should comply with Lipinskis rules of five to a greater degree.

  • In this way, modern antimicrobials should not alter the host microbiome and not generate the phenomenon of dysbiosis .

  • To a greater extent, symbiotic anti-infective therapy should seek to restore equilibrium interaction between the host and its symbiont s as part of the healing process.

  • Finally, the possible toxicities and adverse reactions must be clearly determined in order to administer the new medications safely and adequately.

Thus, the promise of nanotechnology to initiate a pharmacological revolution requires the redesign of innovative preclinical evaluation models that take into account new approaches beyond the terms microbicide and microbiostatics such as antibiotic adjuvants, the inhibition of virulence mechanisms and of quorum-sensing system signals, and the antibiofilm activity, as well as preventing adhesion and colonization in the case of nanosurfaces in hospital spaces and on medical equipment. In the same way, it is necessary to establish the correct parameters of nanotoxicity that allow scientists to evaluate the safety and lethal dose of nanomaterials in patients and the environment.

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