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Mottram - Drugs in Sport

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Mottram Drugs in Sport
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Section 1. The basis for and regulation of druge use in sports -- section 2. Substances and methods prohibited in sport -- section 3. Substances and methods permitted in sport -- section 4. The extent of doping in sport.;Drugs in Sport is the most comprehensive and accurate text available on this complex and controversial subject. Now in a fully revised and updated fifth edition, taking into account the latest regulations, methods and landmark cases, the book explores the hard science behind drug use in sport, as well as the ethical, social, political and administrative contexts. It is supported throughout by data, illustrative case studies, and references for further reading.

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Drugs in Sport

Drug use and abuse is perhaps the biggest challenge facing sport today. However, in the eye of the storm of public and press opinion and with medals and morals at stake it can be difficult to gain a clear perspective on this complex issue. Drugs in Sport is the most comprehensive and accurate text available on the subject. Now in a fully revised and updated fifth edition, taking into account the latest regulations, methods and landmark cases, the book explores the hard science behind drug use in sport, as well as the ethical, social, political and administrative context. Key topics include:

Mode of action and side effects of each major class of drugs used in sport

Discussion of cutting-edge issues, including gene doping

The latest doping control regulations of the World Anti-Doping Agency (WADA)

Methods and advances in doping control, including new intelligence-led detection policies

The use of Therapeutic Use Exemption for certain drugs banned in sport

Issues surrounding non-prohibited substances and ergogenic aids

An assessment of the prevalence of drug taking in sport

Accessibly written, extensively referenced, and supported throughout with illustrative case studies and data, Drugs in Sport provides a comprehensive, objective resource for students and researchers, athletes, sports scientists, coaches, journalists, sports administrators and policymakers.

David R. Mottram is Emeritus Professor of Pharmacy Practice at Liverpool John Moores University. His research interests have centred on the use of drugs in sport with particular emphasis on over-the-counter drugs. He is the editor of 4 previous editions of Drugs in Sport.

Drugs in Sport

Fifth Edition

Edited by David R. Mottram

Drugs in Sport - image 1

LONDON AND NEW YORK

First published 1988

Second edition 1996

Third edition 2003

Fourth edition 2005

Fifth edition 2011
by Routledge
2 Park Square, Milton Park, Abingdon, Oxon OX14 4RN

Simultaneously published in the USA and Canada
by Routledge
270 Madison Avenue, New York, NY10016

Routledge is an imprint of the Taylor & Francis Group

This edition published in the Taylor & Francis e-Library, 2011.


To purchase your own copy of this or any of Taylor & Francis or Routledges collection of thousands of eBooks please go to www.eBookstore.tandf.co.uk.

1988, 1996, 2003, 2005, and 2011 David R. Mottram for selection and editorial matter; individual chapters the contributors

The right of David Mottram to be identified as author of the editorial material, and of the authors for their individual chapters has been asserted in accordance with sections 77 and 78 of the Copyright, Designs and Patents Act 1988.

All rights reserved. No part of this book may be reprinted or reproduced or utilised in any form or by any electronic, mechanical, or other means, now known or hereafter invented, including photocopying and recording, or in any information storage or retrieval system, without permission in writing from the publishers.

British Library Cataloguing in Publication Data
A catalogue record for this book is available from the
British Library

Library of Congress Cataloging in Publication Data
Drugs in sport / edited by David Mottram. 5th ed.
p. cm.
Includes bibliographical references and index.
1. Doping in sports. I. Mottram, D. R. (David R.), 1944 [DNLM: 1. Doping in Sports. 2. Sports Medicine. 3. Substance-Related Disorders. QT 261 D7944 2011]
RC1230.D786 2011
362.29dc22 2010017015

ISBN 0-203-87382-3 Master e-book ISBN

ISBN 978-0-415-55086-4(hbk)

ISBN 978-0-415-55087-1(pbk)

ISBN 978-0-203-87382-3(ebk)

This edition of Drugs in Sport is dedicated to Tom Reilly who died in June 2009. Tom was the first Professor of Sports Science in the UK and had an exemplary record in teaching and research. He had been a contributor to this book since its first edition in 1988. Tom is sadly missed by his colleagues.

Contents


DAVID R. MOTTRAM


DAVID R. MOTTRAM


MARK STUART


ALAN J. GEORGE AND DAVID R. MOTTRAM


ALAN J. GEORGE AND DAVID R. MOTTRAM


DAVID J. ARMSTRONG AND DAVID R. MOTTRAM


DAVID R. MOTTRAM


DAVID R. MOTTRAM


DAVID J. ARMSTRONG


DAVID R. MOTTRAM


DOMINIC J. WELLS


DAVID R. MOTTRAM


PETER N. ELLIOTT


DAVID R. MOTTRAM


PETER N. ELLIOTT


THOMAS REILLY


DAVID R. MOTTRAM


DON MACLAREN


DAVID R. MOTTRAM


NEIL CHESTER


NEIL CHESTER


PETER N. ELLIOTT


THOMAS REILLY AND JIM WATERHOUSE


DAVID J. ARMSTRONG


DAVID R. MOTTRAM

Contributors

David J. Armstrong

Peter N. Elliott

David R. Mottram

School of Pharmacy and Biomolecular Sciences Liverpool John Moores University Byrom Street Liverpool L3 3AF UK

Neil Chester

Don MacLaren

Thomas Reilly

Jim Waterhouse

Centre for Sport and Exercise Science Liverpool John Moores University Byrom Street Liverpool L3 3AF UK

Mark Stuart

International Forum on Quality and Safety in Health Care BMJ Group Ltd. BMA House Tavistock Square London WC1H 9JR

Dominic J. Wells

Gene Targeting Group, Department of Cellular and Molecular Neuroscience Division of Neuroscience and Mental Health Imperial College London Hammersmith Hospital Campus 160, Du Cane Road London W12 0NN

Section I
The basis for and regulation of drug use in sport
Chapter 1
An introduction to drugs and their use in sport

David R. Mottram

1.1Definition of a drug

Drugs are chemical substances that, by interaction with biological targets, can alter the biochemical systems of the body. The branch of science investigating drug action is known as pharmacology. Interactions may be mediated through a variety of target tissues within the body. For example, effects on cardiac muscle by drugs such as ephedrine can be an increase in the force and rate of beating of the heart; stimulation of nerve endings in the central nervous system by drugs such as amphetamine can produce changes in mood and behaviour; interaction with metabolic processes with drugs such as insulin can be used in the treatment of disorders such as diabetes.

In this chapter, frequent reference is made to drugs on the World Anti-Doping Agency (WADA) Prohibited List. The 2010 version of this list is presented in .

1.2Classification and description of drug names

Drugs are variously classified and described by their:

generic name (international non-proprietary name, INN)

proprietary name (manufacturers name)

mechanism of action.

The generic name (INN) is the internationally recognised name of the drug and should normally be used when describing the drug.

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