Mark J. Poznansky - Saved by Science

The future of mankind is far from secure. I am among many who believe that humanity is in crisis; in particular, our personal health, the security of our food supply and the health of our environment all face potentially catastrophic challenges. Our health faces many unresolved dangers in the areas of cancer, infectious diseases and mental health. Rapid population growth and the many environmental challenges in our agricultural systems raise questions about how we will feed the world in the year 2050. Global warming and climate change are threatening our environments, and pollution is poisoning our land, lakes, rivers and oceans.

While these challenges are monumental and the future may appear bleak, there is hope. Imagine being able to:

• Identify specific genetic mutations of a whole range of cancers and to develop personalized and specific therapies (i.e., cures), even at the patients bedside.
• Modify the genetic mutation that predisposes people to suffer from schizophrenia, bipolar disease, severe depression or addictive disorders and to offer effective cures.
• Respond to any viral outbreak (such as Ebola, Zika, AIDS, a nasty flu or COVID-19) with an effective vaccine produced in only days or even hours.
• Grow nutritious, inexpensive, high-protein foods in the widest range of possible conditions of temperature, sunlight, water and fertility... or even on Mars.
• Create real meat without killing animals or to produce real milk without milking cows.
• Provide plants with nitrogen from the air instead of having to mine or chemically synthesize expensive nitrogen fertilizers.
• Reverse global warming by removing carbon from the atmosphere and using it as an energy source or material for advanced manufacturing.
• Use microbes to clean up lakes and rivers, removing lead, mercury and other toxic materials and returning our waterways to pristine condition.
• Design specific microbes to clean up toxic-waste dumps, abandoned mines and industrial sites, and even to clean up disastrous oil spills.

A mere six or seven years ago, these imaginings would have been purely the stuff of science fiction. Today, we have realistic expectations that theyll happen and that theyll be brought to market within a decade, maybe even less. These are the products of what some call the fourth industrial revolution, a marriage of computer science and newfound knowledge in biology, particularly genomics. This book is about that revolution, a new field of science called synthetic biology and the hope and promise that it offers for the future of mankind.

A note to readers: This book is aimed not at a science audience but, rather, at people who want or need to know how humans are goingto overcome some of our major hurdles in health, food and the environment. Following the main text, Ive included a glossary and a genetics primer that may help you navigate some of the science that, by necessity, is included in the book.