Table of Contents
Guide
Pages
Antibiotics Manual
A Guide to Commonly Used Antimicrobials
Second Edition
David Scholssberg MD, FACP, FIDSA, FCPP
The Lewis Katz School of Medicine at Temple University Philadelphia, PA, USA
Rafik Samuel, MD, FACP, FIDSA, FCPP
The Lewis Katz School of Medicine at Temple University Philadelphia, PA, USA
This edition first published 2017
2017 John Wiley & Sons Ltd
Edition History
PMPHUSA, Ltd (1e, 2011)
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Library of Congress CataloginginPublication Data
Names: Schlossberg, David, author. | Samuel, Rafik, author.
Title: Antibiotics manual : a guide to commonly used antimicrobials / by David Schlossberg, Rafik Samuel.
Description: Second edition. | Hoboken, NJ : Wiley, 2017. | Includes bibliographical references and index.
Identifiers: LCCN 2017028213 (print) | LCCN 2017029407 (ebook) | ISBN 9781119220770 (pdf) | ISBN 9781119220763 (epub) | ISBN 9781119220756 (pbk.)
Subjects: | MESH: AntiBacterial Agentsadministration & dosage | AntiBacterial Agentstherapeutic use | Handbooks
Classification: LCC RM267 (ebook) | LCC RM267 (print) | NLM QV 39 | DDC 615/.329dc23
LC record available at https://lccn.loc.gov/2017028213
Cover Design: Wiley
Cover Image: everything possible/Shutterstock
Once again, for Yuan:
Shall I compare thee to a summers day?
Thou art more lovely and more temperate.
Rough winds do shake the darling buds of May,
And summers lease hath all too short a date.
.
But thy eternal summer shall not fade,
Nor lose possession of that fair thou owst
Shakespeare, Sonnet 18.
David Schlossberg
This book is dedicated to my family, Farid, Leila, Dalia, Ed, and Matt. Thank you all; you are the reason I am the person I am today.
Rafik Samuel
PREFACE
We are pleased to present the Second Edition of our book. The development of new antimicrobials since the First Edition has been explosive, necessitating the addition of 36 new chapters, comprising new antiretroviral, antiHCV, antimycobacterial, antifungal and antibacterial drugs and combinations. All the older chapters have been updated as necessary, and new tables have been added that highlight salient antimicrobial toxicities and indicate potential specific coverage of difficult pathogens.
As with the First Edition, we intend this book to fill an important particular niche in the clinicians arsenal: it is a compilation of individual brief chapters, each dedicated to a specific antimicrobial. The final chapter of formulas, equations, and useful definitions now also includes the toxicity and coverage tables mentioned above. Each antimicrobial chapter lists the drugs class, mechanism of action, mechanism of resistance, metabolic route, indications and offlabel uses, pertinent toxicities, significant drug interactions, and dosage for routine and special populations. The emphasis of this book is not on recommendations for specific organisms or clinical syndromes; rather, it is a compendium of clinically helpful information about available antimicrobials.
We have included the FDAapproved indications as they exist currently; additional offlabel uses are also included. For many agents, the toxicities and drug interactions are numerous and complex; frequently, the clinician must research several sites or even multiple locations in the drug label itself to identify significant toxicities. We have tried to organize the most frequent and important toxicities and drug interactions in a convenient, userfriendly format.
Dosage information includes the special populations of renal failure, hepatic dysfunction, and pediatrics, and each chapter concludes with a list of clinical pearls, adding practical tips to the preceding discussion. When possible, we have used the official drug label as a primary source of information, supplemented by the various print and electronic sources in the References; further details may be sought in these resources.
In addition to FDAapproved indications, we have also listed offlabel uses of selected agents; further, since many of the antiparasitic drugs are difficult to acquire in the United States, we have supplied relevant contact information for the CDC or compounding pharmacies, when appropriate.
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