Contents
Guide
Pages
SEVENTH EDITION
WYLLIES TREATMENT OF EPILEPSY
PRINCIPLES AND PRACTICE
SEVENTH EDITION
WYLLIES TREATMENT OF EPILEPSY
PRINCIPLES AND PRACTICE
Editor-in-Chief
Elaine Wyllie , MD
Professor of Neurology
Cleveland Clinic Lerner College of Medicine
Epilepsy Center, Neurological Institute
Cleveland Clinic
Cleveland, Ohio
Associate Editors
Barry E. Gidal , PharmD, FAES
Professor
Department of Neurology
School of Pharmacy
Chair, Pharmacy Practice Division
University of Wisconsin
Madison, Wisconsin
Howard P. Goodkin , MD, PhD
The Shure Professor of Neurology and PediatricsUniversity of VirginiaChair, Department of NeurologyDirector, Division of Pediatric NeurologyDepartment of NeurologyUniversity of Virginia HealthCharlottesville, Virginia
Lara Jehi , MD, MHCDS
Professor of Neurology
Cleveland Clinic Lerner College of Medicine
Chief Research Information Officer
Cleveland Clinic
Cleveland, Ohio
Tobias Loddenkemper , MD
Professor, Department of NeurologyHarvard Medical SchoolDirector of Clinical Research, Division of Epilepsy and ClinicalNeurophysiologyBoston Childrens HospitalBoston, Massachusetts
Acquisitions Editor: Chris Teja
Development Editor: Ariel S. Winter
Editorial Coordinator: Julie Kostelnik
Editorial Assistant: Brian Convery
Marketing Manager: Phyllis Hitner
Production Project Manager: Bridgett Dougherty
Design Coordinator: Terry Mallon
Manufacturing Coordinator: Beth Welsh
Prepress Vendor: SPi Global
Seventh Edition
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This work is no substitute for individual patient assessment based upon healthcare professionals examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments.
Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturers package insert) accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work.
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Dedication
To my partner in life and dance, Dr. Robert Wyllie,
To all the outstanding caregivers at Cleveland Clinic,
And to the people who entrust us with their care.
About the Author
Dr. Elaine Wyllie, Professor of Neurology at Cleveland Clinic Lerner College of Medicine, is an epilepsy specialist at Cleveland Clinic who provides cutting-edge treatment for children from around the world. Creating seven editions of Wyllies Treatment of Epilepsy is one of her signature achievements. She is also the author of The Cleveland Clinic Guide to Epilepsy, an authoritative book for the lay public. Dr. Wyllie has published over 250 scientific reports, and her contributions to the field have been recognized by honors including the American Epilepsy Societys prestigious Research Award. Dr. Wyllie also received Cleveland Clinics coveted Master Clinician Award, which is presented to a single physician once a year for commitment to outstanding patient care. She has recently become active in social media and authors a regular blog on epilepsy for US News & World Report. Cleveland Clinic has highlighted her in a series of epilepsy education videos available at www.clevelandclinic.org/epilepsy.
On the personal side, Dr. Wyllie is a dedicated wife, mother, and ballroom dancer. By successfully balancing family, work, and personal fitness throughout her productive career, she hopes to encourage and inspire young doctors to passionately pursue their own professional goals.
Contributors
Nicholas S. Abend , MD, MSCE
Associate Professor of Neurology, Pediatrics, and Anesthesia & Critical Care Medicine
Perelman School of Medicine at the University of Pennsylvania
Director of Clinical Neurophysiology and Attending Neurologist
Department of Pediatrics (Neurology)
Childrens Hospital of Philadelphia
Philadelphia, Pennsylvania
Hamada Hamid Altalib , DO, MPH, FAES
Associate Professor
Departments of Neurology and Psychiatry
Yale School of Medicine
Director, Yale Epilepsy Outcomes Research
Director, Epilepsy Center of Excellence
Connecticut Veterans Affairs Healthcare System
West Haven, Connecticut
Gail D. Anderson, PhD
Professor
Department of Pharmacy
School of Pharmacy
University of Washington
Seattle, Washington
Erika Takle Axeen , MD
Assistant Professor
Neurology Department
University of Virginia School of Medicine
UVA Health
Charlottesville, Virginia
Jacquelyn L. Bainbridge , BSPharm, PharmD, FCCP, MSCS, FAES