Francis P. Worden - Cancer Pharmacology and Pharmacotherapy Review: Study Guide for Oncology Boards and MOC Exams

Contents Cancer Pharmacology and Pharmacotherapy Review Cancer Pharmacology and Pharmacotherapy Review Study Guide for Oncology Boards and MOC Exams Francis P. Worden, MD, RPh Professor Division of Hematology/Oncology Department of Internal Medicine University of Michigan Health System Ann Arbor, Michigan Anthony J. Perissinotti, PharmD, BCOP Clinical Pharmacist Specialist, Inpatient Hematology Adjunct Clinical Assistant Professor Department of Pharmacy University of Michigan Health System Ann Arbor, Michigan Bernard L. Marini, PharmD Clinical Pharmacist Specialist, Inpatient Hematology Adjunct Clinical Assistant Professor Department of Pharmacy University of Michigan Health System Ann Arbor, Michigan Visit our website at www.demosmedical.comISBN: 9781620700761 e-book ISBN: 9781617052521 Acquisitions Editor: David DAddona Compositor: Exeter Premedia Services Copyright 2016 Springer Publishing Company. Demos Medical Publishing is an imprint of Springer Publishing Company, LLC. All rights reserved.

This book is protected by copyright. No part of it may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the publisher. Medicine is an ever-changing science. Research and clinical experience are continually expanding our knowledge, in particular our understanding of proper treatment and drug therapy. The authors, editors, and publisher have made every effort to ensure that all information in this book is in accordance with the state of knowledge at the time of production of the book. Nevertheless, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the contents of the publication.

Every reader should examine carefully the package inserts accompanying each drug and should carefully check whether the dosage schedules mentioned therein or the contraindications stated by the manufacturer differ from the statements made in this book. Such examination is particularly important with drugs that are either rarely used or have been newly released on the market. Library of Congress Cataloging-in-Publication Data Names: Worden, Francis P., author. | Perissinotti, Anthony J., author. | Marini, Bernard L., author. Title: Cancer pharmacology and pharmacotherapy review : study guide for oncology boards and MOC exams / Francis P.

Worden, Anthony J. Perissinotti, Bernard L. Marini. Description: New York : Demos Medical, [2016] Identifiers: LCCN 2015045238| ISBN 9781620700761 | ISBN 9781617052521 (ebook) Subjects: | MESH: Antineoplastic AgentspharmacologyExamination Questions. | Neoplasmsdrug therapyExamination Questions. Classification: LCC RS431.A64 | NLM QV 18.2 | DDC 615.7/98076dc23 LC record available at http://lccn.loc.gov/2015045238

Printed in the United States of America by McNaughton & Gunn. 16 17 18 19 / 5 4 3 2 1 We dedicate this book to our patients for their willingness to participate in clinical trials. Without their fortitude and willingness to participate in clinical trials, new drug discoveries and the advancement of the field of oncologic medicine would not be possible. Contents List of Figures Chapter 1Chapter 2Chapter 3Chapter 5Chapter 8Chapter 12 List of Tables Chapter 1Chapter 2Chapter 3Chapter 4Chapter 5Chapter 6Chapter 8Chapter 9Chapter 10Chapter 11Chapter 13Chapter 14Chapter 16 Preface In preparing for clinics, rounding, or board examinations, understanding the pharmacology of the drugs and agents can be overwhelming. In medical school and residency, it is often difficult to keep up with the mechanisms of action, kinetics, and dosing schedules of so many common medications, let alone those that are used in more rare conditions, including cancer. When residents become hematology and oncology fellows, they are forced to learn a large cohort of medications very quickly, a task that is daunting, given the ever-expanding market of new chemotherapeutic agents. Additionally, questions on the hematology and oncology board examinations related to pharmacology represent a relatively larger percentage.

This is true, given that the facts focusing on the mechanisms and side effects of these drugs do not change. Moreover, we are often asked dose-limiting side effects of medications as well as the requirements for dosage reductions related to kidney and liver failure. The University of Michigan Hematology/Oncology Fellowship Program recently published an oncology board review book, Oncology Boards Flash Review, to help solidify the knowledge one needs to have for his or her test. As a companion to this manual, we have written a similar board review book to summarize information that is most pertinent to the pharmacology of chemotherapeutic agents used by practicing hematologists and oncologists. This book contains concise summaries of the various chemotherapeutic drugs by class, pharmacology, pharmacokinetics, and toxicities and includes, to date, all of the U.S. Food and Drug Administration (FDA)-approved oncology agents available to practicing clinicians.

It is our hope that fellows and practicing medical hematologists/oncologists preparing for ward rounds, outpatient clinical rotations, or for their certification or recertification examinations will find our book to be a useful tool. Our goal is to help our readers summarize and solidify many important clinical facts and to help them build confidence in their knowledge of oncologic drugs. The successful completion of this project was made possible by the editorial staff of Demos Medical Publishing, especially David DAddona, acquisitions editor, and Joseph Stubenrauch, production editor. Francis P. Worden, MD, RPhAnthony J. Perissinotti, PharmD, BCOPBernard L.

Marini, PharmD