Jeffrey Myers - Cancer of the Head and Neck

Jeffrey N. Myers, MD, PhD, FACS

Olive and Hubert Stringer Distinguished Professor in Cancer Research
Department of Head and Neck Surgery
The University of Texas MD Anderson Cancer Center
Houston, Texas

Ehab Y. N. Hanna, MD, FACS

Professor and Vice Chairman
Charles and Daneen Stiefel Chair in Cancer Research
Co-Director of Skull Base Surgery
Department of Head and Neck Surgery
Medical Director, Head and Neck Center
The University of Texas MD Anderson Cancer Center
Houston, Texas

Eugene N. Myers, MD, FACS, FRCS Edin (Hon)

Distinguished Professor and Emeritus Chair
Department of Otolaryngology
University of Pittsburgh School of Medicine
Professor, Department of Oral Maxillofacial Surgery
University of Pittsburgh School of Dental Medicine
Pittsburgh, Pennsylvania

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Fifth Edition

Copyright 2017 Wolters Kluwer

Editions 1-4:

Copyright 2003, 1996, 1989, Elsevier Science (USA). All Rights Reserved

Copyright 1987, Mosby, Inc. All Rights Reserved

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Library of Congress Cataloging-in-Publication Data

Names: Myers, Jeffrey (Jeffrey N.), editor. | Hanna, Ehab Y., editor. | Myers, Eugene N., 1933- editor.Title: Cancer of the head and neck / [edited by] Jeffrey N. Myers, Ehab Y.N. Hanna, Eugene N. Myers.Other titles: Cancer of the head and neck (Myers)

Description: Fifth edition. | Philadelphia : Wolters Kluwer, [2017] | Includes bibliographical references and index.

Identifiers: LCCN 2016015692 | ISBN 9781451191134

Subjects: | MESH: Head and Neck Neoplasms

Classification: LCC RC280.H4 | NLM WE 707 | DDC 616.99/491dc23 LC record available at https://lccn.loc.gov/2016015692

This work is provided as is, and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work.

This work is no substitute for individual patient assessment based upon healthcare professionals examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments.

Given continuous, rapid advances in medical science and health information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the product information sheet (the manufacturers package insert) accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify any changes in dosage schedule or contraindications, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maximum extent permitted under applicable law, no responsibility is assumed by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence law or otherwise, or from any reference to or use by any person of this work.

LWW.com

This book is dedicated to my wife, Lisa, and our children, Keith Nicholas Myers, Brett Alexander Myers, and Blake David Myers, and to my parents, Eugene and Barbara Myers.

JNM

This book is dedicated to my wife, Sylvie, for her grace, sacrifice, and support throughout my career; our daughters, Gabrielle Grace (Gigi) Hanna and Camille Lauren Hanna, for the joy and blessing they bring to our lives; my parents who encouraged me to follow my dreams; my mentors who inspired me to pursue excellence; my residents and students who continue to teach me; and my patients whose endurance, resilience, and faith continue to amaze me.

EYH

This book is dedicated to my wife and best pal, Barbara; our son, Jeffrey N. Myers, MD, PhD, his wife, Lisa, and their sons, Keith N. Myers, Brett A. Myers, and Blake D. Myers; our daughter, Marjorie M. Fulbright, her husband, Cary, and their sons, Alexander F. Fulbright and Charles J. Fulbright, who are a constant source of joy and inspiration; to my parents, the late Dr. David and Rosalind N. Myers, whose dedication to patient care was a way of life; to the late Dr. John Conley with whom I learned the principles of Head and Neck Surgery; and to Dr. James Y. Suen who invited me to be his partner in writing

Cancer of the Head and Neck.
ENM

Ruth A. Aponte-Wesson, DDS, MS, FACP

Associate Professor
Department of Head and Neck Surgery
Section of Oral Oncology and Maxillofacial Prosthodontics
The University of Texas MD Anderson Cancer Center
Houston, Texas

Ryan M. Aronberg, MD, MS

Department of Surgery, Otolaryngology
Yale School of Medicine
New Haven, Connecticut

Carol R. Bradford, MD, FACS

Professor
Department of OtolaryngologyHead and Neck Surgery
University of Michigan Health System
Ann Arbor, Michigan

Eduardo Bruera, MD

FT McGraw Chair in the Treatment of Cancer
Chair, Department of Palliative, Rehabilitation, and Integrative Medicine
The University of Texas MD Anderson Cancer Center
Houston, Texas

Malcolm A. Buchanan, BSc (Hons), MBChB, PhD, FRCS (ORL-HNS)

Postgraduate Fellow in Head and Neck Surgery
Department of OtolaryngologyHead and Neck Surgery
Westmead Hospital
Sydney, Australia

Daniel Buchbinder, MD

Department of Oral and Maxillofacial Surgery
Department of OtolaryngologyHead and Neck Surgery
Mount Sinai Beth Israel
New York, New York

Richard C Cardoso. , DDS, MS, FACP

Assistant Professor
Section of Oral Oncology
Department of Head and Neck Surgery
The University of Texas MD Anderson Cancer Center
Houston, Texas

Jerry Castro, MD

Department of OtolaryngologyHead and Neck Surgery
Guam Memorial Hospital
Guam

Mark S. Chambers, DMD, MS

Professor
Department of Head and Surgery
Chief and Medical Director, Section of Oral Oncology and Maxillofacial Prosthodontics
Vice Chair (HNS), Research Compliance and Regulatory Affairs
Chair, Institutional Review Board 5