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Charles N. Serhan - Molecular and Cellular Basis of Inflammation (Current Inflammation Research)

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This collection of cutting-edge reviews of the molecular and cellular bases of inflammatory processes makes an important and timely contribution to the search for new antiinflammatory agents. The book authoritatively reviews the role of protein and lipid mediators in inflammation, cellular processes of importance in the initiation and determination of inflammation, signal transduction events of interest in the development of potential new therapeutic targets, and drug design issues in inflammation therapeutics. In addition, several chapters summarize state-of-the-art findings in disease processes where inflammation plays a critical role. Reflecting the work of leading researchers in molecular biology, biochemistry, pharmacology, immunology, and pathobiology, Molecular and Cellular Basis of Inflammation establishes new basic concepts in the elucidation of molecular mechanisms in inflammation.

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title Molecular and Cellular Basis of Inflammation Current Inflammation - photo 1

title:Molecular and Cellular Basis of Inflammation Current Inflammation Research
author:Serhan, Charles N.
publisher:Humana Press
isbn10 | asin:0896035956
print isbn13:9780896035959
ebook isbn13:9780585227795
language:English
subjectInflammation--Mediators, Inflammation--Immunological aspects, Inflammation--immunology, Immunity, Cellular--physiology.
publication date:1999
lcc:RB131.M73 1999eb
ddc:616/.0473
subject:Inflammation--Mediators, Inflammation--Immunological aspects, Inflammation--immunology, Immunity, Cellular--physiology.
Page i
Molecular and Cellular Basis of Inflammation
Page ii
Current Inflammation Research
Charles N. Serhan, Series Editor
Molecular and Cellular Basis of Inflammation, edited by Charles N. Serhan and Peter A. Ward, 1999
Page iii
Molecular and Cellular Basis of Inflammation
Edited by
Charles N. Serhan
Harvard Medical School,
Brigham
and Women's Hospital Boston, MA
and
Peter A. Ward
University of Michigan, Ann Arbor, MI
Humana Press Picture 2 Totowa, New Jersey
Page iv
1999 Humana Press Inc.
999 Riverview Drive, Suite 208
Totowa, New Jersey 07512
All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher.
All authored papers, comments, opinions, conclusions, or recommendations are those of the author(s), and do not necessarily reflect the views of the publisher.
This publication is printed on acid-free paper. Picture 3
ANSI Z39.48-1984 (American National Standards Institute) Permanence of Paper for Printed Library Materials.
Cover design by Patricia F. Cleary.
For additional copies, pricing for bulk purchases, and/or information about other Humana titles, contact Humana at the above address or at any of the following numbers: Tel.:973-256-1699; Fax:973-256-8341; E-mail: humana@humanapr.com or visit our Web site: http://humanapress.com
Photocopy Authorization Policy:
Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Humana Press Inc., provided that the base fee of US $8.00 per copy, plus US $00.25 per page, is paid directly to the Copyright Clearance Center at 222 Rosewood Drive, Danvers, MA 01923. For those organizations that have been granted a photocopy license from the CCC, a separate system of payment has been arranged and is acceptable to Humana Press Inc. The fee code for users of the Transactional Reporting Service is: [0-89603-595-6/ 98 $8.00 + $00.25].
Printed in the United States of America. 10 9 8 7 6 5 4 3 2 1
Library of Congress Cataloging in Publication Data
Molecular and cellular basis of inflammation/edited by Charles N. Serhan and Peter A. Ward
p. cm.
Includes bibliographical references and index.
ISBN 0-89603-595-6 (alk. paper)
1. InflammationMediators. 2. InflammationImmunological aspects. I. Serhan, Charles N.
II. Ward, Peter A., 1934
[DNLM: 1. Inflammationimmunology. Immunity, Cellularphysiology. QW 700 M7175 1999]
RB131.M73 1999
616'.0473dc21
DNLM/DLC
for Library of Congress 98-47837
CIP
Page v
Preface
The study of inflammation has captured the interest of scholars since the earliest recorded history. Symbols identifying the cardinal signs of inflammation were uncovered in both Sanskrit and hieroglyphics (1). Since complete appreciation of the inflammatory process is underscored by the need for knowledge at both the cellular and molecular levels, academic inquiry in the area of inflammation has led, in many respects, the foray of current biomedical research. Molecular and Cellular Basis of Inflammation represents research from the cutting edge in the broad view of inflammation. The chapters are written by experts with a multidisciplinary approach to the study of inflammatory and cellular processes, and thus include contributions form the fields of molecular biology, biochemistry, pharmacology, immunology, and pathobiology.
Molecular and Cellular Basis of Inflammation was first conceived during a minisymposium sponsored by the American Society for Investigative Pathology held at FASEB in 1995 entitled "The Role of Reactive Lipids, Oxygen and Nitrogen Metabolites in Inflammation," at which several of the contributing authors delivered lectures. This present, much-extended volume includes leading-front descriptions of both protein and lipid mediators. The chapter devoted to the complement cascade by Ward and colleagues, as well as Chapters 37 and 13, provide up-to-date descriptions of the biosynthesis, molecular biology, chemistry, and actions of both protein and lipid mediators. Chapter 3, by Haeggestrom and Serhan, provides an overview and update of eicosanoids, with a particular focus on the biosynthesis and actions of leukotrienes and lipoxins in disease models. An overview of the molecular biology and enzymology of the cascade, including a detailed account of the mutagenesis of the 5-lipoxygenase, an enzyme that plays a central role in leukotriene generation, is given by Dr. Rdmark of the Karolinska Institute, Stockholm, from which much of the work on inflammatory mediators emanated historically.
Chapter 5 focuses on the use of targeted gene disruption models in mice for the elucidation of the role of lipid mediators in inflammation and is contributed by Dr. Colin Funk and colleagues, who generated some of the initial work in this area and now provide an authoritative review of the status of the use of knockout mice.
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