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Philip V. Peplow - Stroke Biomarkers

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Philip V. Peplow Stroke Biomarkers

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Contents
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Volume 147 Neuromethods Series Editor Wolfgang Walz University of - photo 1
Volume 147
Neuromethods
Series Editor
Wolfgang Walz
University of Sasatchewan, Saskatoon, SK, Canada

For further volumes: http://www.springer.com/series/7657

Neuromethods publishes cutting-edge methods and protocols in all areas of neuroscience as well as translational neurological and mental research. Each volume in the series offers tested laboratory protocols, step-by-step methods for reproducible lab experiments and addresses methodological controversies and pitfalls in order to aid neuroscientists in experimentation. Neuromethods focuses on traditional and emerging topics with wide-ranging implications to brain function, such as electrophysiology, neuroimaging, behavioral analysis, genomics, neurodegeneration, translational research and clinical trials. Neuromethods provides investigators and trainees with highly useful compendiums of key strategies and approaches for successful research in animal and human brain function including translational bench to bedside approaches to mental and neurological diseases.

Editors
Philip V. Peplow , Bridget Martinez and Svetlana A. Dambinova
Stroke Biomarkers
Editors Philip V Peplow Department of Anatomy University of Otago Dunedin - photo 2
Editors
Philip V. Peplow
Department of Anatomy, University of Otago, Dunedin, New Zealand
Bridget Martinez
Physical Chemistry and Applied Spectroscopy, Chemistry Division, Los Alamos National Lab, Los Alamos, NM, USA
Svetlana A. Dambinova
Brain Biomarkers Research Lab, Emory Decatur Hospital, Emory Healthcare, Decatur, GA, USA
Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia
ISSN 0893-2336 e-ISSN 1940-6045
Neuromethods
ISBN 978-1-4939-9681-0 e-ISBN 978-1-4939-9682-7
https://doi.org/10.1007/978-1-4939-9682-7
Springer Science+Business Media, LLC, part of Springer Nature 2020
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Cover illustration: This custom piece was created by Dr. Bridget Martinez and Donald Mario Robert Harker; using acrylic paint on canvas with the addition of graphic design.

This Humana imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature.

The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.

This custom piece was created by Dr Bridget Martinez and Donald Mario Robert - photo 3

This custom piece was created by Dr. Bridget Martinez and Donald Mario Robert Harker; using acrylic paint on canvas with the addition of graphic design

This artistic rendition encapsulates the hemispherical dominances in a visual capacity. Whereas one represents an objective, linear, logical, analytical and sequential school of thought, the other reveals itself to be less reasonable and dabbles in the idiosyncrasies of subjectivity by manifesting itself as a holistic network invoking an emotional, more intuitive and creative thought. Yet whether it is the poet or the accountant which dominates in each of us, it has become increasingly clear that the complete absence of either, leaves one in a universe devoid of both rhyme and reason.

Dedication

This book is dedicated to our universe which inspires, challenges, creates, and molds beauty, even from the most unexpected corners and circumstances. The pursuit of knowledge is a great adventure. In loving memory of my father Elmer Martinez. Endless gratitude to my mother Eda Noguera, my sister Karla Zeo Sanchez, and my brother Elmer Martinez.

Bridget Martinez

The world is still a beautiful place and full of kindness and love. I wish to dedicate this book to Bridget who is a shining light and inspiration in my life and also to my family, friends, and colleagues for their support and encouragement.

Philip V. Peplow

In memory of Robert Rose Rhinehart, a strong believer in a great future of brain biomarkers and constant support.

Svetlana A. Dambinova

Preface to the Series

Experimental life sciences have two basic foundations: concepts and tools. The Neuromethods series focuses on the tools and techniques unique to the investigation of the nervous system and excitable cells. It will not, however, shortchange the concept side of things as care has been taken to integrate these tools within the context of the concepts and questions under investigation. In this way, the series is unique in that it not only collects protocols but also includes theoretical background information and critiques which led to the methods and their development. Thus, it gives the reader a better understanding of the origin of the techniques and their potential future development. The Neuromethods publishing program strikes a balance between recent and exciting developments like those concerning new animal models of disease, imaging , in vivo methods, and more established techniques, including, immunocytochemistry and electrophysiological technologies. New trainees in neurosciences still need a sound footing in these older methods in order to apply a critical approach to their results.

Under the guidance of its founders, Alan Boulton and Glen Baker, the Neuromethods series has been a success since its first volume published through Humana Press in 1985. The series continues to flourish through many changes over the years. It is now published under the umbrella of Springer Protocols. While methods involving brain research have changed a lot since the series started, the publishing environment and technology have changed even more radically. Neuromethods has the distinct layout and style of the Springer Protocols program, designed specifically for readability and ease of reference in a laboratory setting.

The careful application of methods is potentially the most important step in the process of scientific inquiry. In the past, new methodologies led the way in developing new disciplines in the biological and medical sciences. For example, Physiology emerged out of Anatomy in the nineteenth century by harnessing new methods based on the newly discovered phenomenon of electricity. Nowadays, the relationships between disciplines and methods are more complex. Methods are now widely shared between disciplines and research areas. New developments in electronic publishing make it possible for scientists who encounter new methods to quickly find sources of information electronically. The design of individual volumes and chapters in this series takes this new access technology into account. Springer Protocols makes it possible to download single protocols separately. In addition, Springer makes its print-on-demand technology available globally. A print copy can therefore be acquired quickly and for a competitive price anywhere in the world.

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