Cass - Natural Highs

Falling is a serious problem among older patients: it is the combination of a high fall incidence together with a high susceptibility to injuries that makes a relatively mild fall potentially dangerous to these old persons. Falling is a multifactorial problem, but postural instability during daily activities, such as walking, is suggested to be the most consistent predictor of falls. Age-related neurophysiological changes and a high prevalence of clinical diseases result in a slower and less coordinated gait in older patients. These changes in the gait pattern can be quantified by a wide variety of gait parameters, each characterizing different aspects of the gait pattern. Several studies among relatively young and healthy older adults have shown that gait characteristics, such as gait speed, stride-to-stride variability, gait asymmetry, harmonic ratios, and sample entropy, can differentiate fallers from non-fallers. However, these results of these studies cannot be extrapolated to older patients, since in these old patients there are, besides the normal age-related neurophysiological changes, additional comorbid factors present that might affect the walking pattern, and consequently increase fall risk. Therefore, in the present thesis, it was aimed to examine the association between several phenomena that occur common in geriatric patients, including osteoporosis-related factors (e.g., vertebral fractures, increased thoracic kyphosis, and a flexed posture; part I of this thesis), medication-use (e.g., fall-risk-increasing drugs, such as antidepressants, benzodiazepines and antiepileptics; part II), and frailty-related factors (e.g., muscle strength and weight loss; part III) with postural control during walking in older patients visiting a geriatric outpatient clinic. Based on the studies described in the first part of this thesis, it was concluded that patients with a flexed posture, an increased thoracic kyphosis, and/or prevalent vertebral fractures have an impa