J. Silvio Gutkind - Signaling networks and cell cycle control: the molecular basis of cancer and other diseases

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title	:	Signaling Networks and Cell Cycle Control : The Molecular Basis of Cancer and Other Diseases Cancer Drug Discovery and Development
author	:	Gutkind, J. Silvio.
publisher	:	Humana Press
isbn10 | asin	:	089603710X
print isbn13	:	9780896037106
ebook isbn13	:	9780585310022
language	:	English
subject	Cellular signal transduction, Cell cycle, Cellular control mechanisms, Pathology, Molecular.
publication date	:	2000
lcc	:	QP517.C45S558 2000eb
ddc	:	571.6
subject	:	Cellular signal transduction, Cell cycle, Cellular control mechanisms, Pathology, Molecular.

Page i Signaling Networks and Cell Cycle Control

Page ii Cancer Drug Discovery and Development Beverly A. Teicher, Series Editor 9. Matrix Metalloproteinase Inhibitors in Cancer Therapy, edited by Neil J. Clendeninn and Krzysztof Appelt, 2000 8. Prenyltransferase Inhibitors in Cancer and Cardiovascular Therapy, edited by Said M. Sebti and Andrew Hamilton, 2000 7. Platinum-Based Drugs in Cancer Therapy, edited by Lloyd R. Kelland and Nicholas P. Farrell, 2000 6. Apoptosis and Cancer Chemotherapy, edited by John A. Hickman and Caroline Dive, 1999 5. Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases, edited by J. Silvio Gutkind, 2000 4. Antifolate Drugs in Cancer Therapy, edited by Ann L. Jackman, 1999 3. Antiangiogenic Agents in Cancer Therapy, edited by Beverly A. Teicher, 1999 2. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, edited by Beverly A. Teicher, 1997 1. Cancer Therapeutics: Experimental and Clinical Agents, edited by Beverly A. Teicher, 1997

Page iii Signaling Networks and Cell Cycle Control The Molecular Basis of Cancer and Other Diseases Edited by J. Silvio Gutkind National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD

Page iv 2000 Humana Press Inc. 999 Riverview Drive, Suite 208 Totowa, New Jersey 07512 For additional copies, pricing for bulk purchases, and/or information about other Humana titles, contact Humana at the above address or at any of the following numbers: Tel.: 973-256-1699; Fax: 973-256-8341; E-mail: humana@humanapr.com or visit our Website: http://humanapress.com All rights reserved. No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher. All articles, comments, opinions, conclusions, or recommendations are those of the author(s), and do not necessarily reflect the views of the publisher. Cover illustration: From Fig. 1 in Chapter 14, "Discovery of TNP-470 and Other Angiogenesis Inhibitors," by Donald E. Ingber, in Cancer Therapeutics: Experimental and Clinical Agents, Edited by Beverly A. Teicher, Humana Press, 1997. Cover design by Patricia F. Cleary. This publication is printed on acid-free paper. ANSI Z39.48-1984 (American National Standards Institute) Permanence of Paper for Printed Library Materials. Photocopy Authorization Policy: Authorization to photocopy items for internal or personal use, or the internal or personal use of specific clients, is granted by Humana Press Inc., provided that the base fee of US $10.00 per copy, plus US $00.25 per page, is paid directly to the Copyright Clearance Center at 222 Rosewood Drive, Danvers, MA 01923. For those organizations that have been granted a photocopy license from the CCC, a separate system of payment has been arranged and is acceptable to Humana Press Inc. The fee code for users of the Transactional Reporting Service is: [0-89603-710-X/00 $10.00 + $00.25]. Printed in the United States of America. 10 9 8 7 6 5 4 3 2 1 Library of Congress Cataloging-in-Publication Data Signaling networks and cell cycle control: the molecular basis of cancer and other diseases/edited by J. Silvio Gutkind. p. cm(Cancer drug discovery and development) Includes bibliographical references and index. ISBN 0-89603-710-X (alk. paper) 1. Cellular signal transduction. 2. Cell cycle. 3. Cellular control mechanisms. 4. Pathology, Molecular. I. Gutkind, J. Silvio. II. Series. QP517.C45 S558 2000 571.6dc 99-056127

Page v Preface In the last few years we have witnessed a real explosion in the knowledge of how cell surface receptors transmit signals to the nucleus, thereby controlling the expression of genetic programs involved in many cellular processes, including normal and aberrant cell growth. We learned that a unique repertoire of signaling molecules link each class of receptors to a variety of newly discovered kinase cascades, in many cases through the activation of small GTP-binding proteins of the Ras superfamily. In turn, these kinases phosphorylate key molecules, including transcription factors, which ultimately control gene expression. Furthermore, recent work is helping to unveil how these signals initiated at the level of the cell surface are integrated in space and time to control the orderly progression through the cell cycle or, alternatively, the exit from the cell cycle and the activation of cellular processes leading to phenotypic differentiation or to programmed cell death. Parallel efforts have revealed that subtle alterations in signal transduction pathways and cell cycle control are implicated in a number of pathological processes, including cancer. Thus, the recent identification of key signaling and cell-cycle-regulating molecules has provided a golden opportunity in the search for novel targets for therapeutic intervention and disease.

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