Katon Wayne - Depression and Heart Disease

World Psychiatric Association titles in the Depression series

In recent years, there has been a growing awareness of the multiple interrelationships between depression and various physical diseases. This series of volumes dealing with the comorbidity of depression with diabetes, heart disease and cancer provides an update of currently available evidence on these interrelationships.

Depression and Diabetes
Edited by Wayne Katon, Mario Maj and Norman Sartorius
ISBN: 9780470688380

Depression and Heart Disease
Edited by Alexander Glassman, Mario Maj and Norman Sartorius
ISBN: 9780470710579

Depression and Cancer
Edited by David W. Kissane, Mario Maj and Norman Sartorius
ISBN: 9780470689660

Related WPA title on depression:

Depressive Disorders, 3e
Edited by Helen Herrman, Mario Maj and Norman Sartorius
ISBN: 9780470987209

For all other WPA titles published by John Wiley & Sons Ltd, please visit the following website pages:

http://eu.wiley.com/WileyCDA/Section/id-305609.xhtml

http://eu.wiley.com/WileyCDA/Section/id-303180.xhtml

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Library of Congress Cataloguing-in-Publication Data

Depression and heart disease / editors, Alexander Glassman, Mario Maj, Norman Sartorius.
p. ; cm.
Includes bibliographical references and index.
ISBN 978-0-470-71057-9 (pbk.)
1. Depression, MentalComplications. 2. HeartDiseasesPsychological aspects. I. Glassman, Alexander H.,
1934- II. Maj, Mario, 1953- III. Sartorius, N.
[DNLM: 1. Depressive Disordercomplications. 2. Depressive Disorderpsychology. 3. Cardiovascular
Diseasesetiology. 4. Cardiovascular Diseasespsychology. WM 171]
RC537.D42746 2011
616.8527dc22
2010027876

List of Contributors

J. Thomas Bigger, Jr. Department of Medicine, Columbia
University College of Physicians and Surgeons, New York, NY, USA

Robert M. Carney Department of Psychiatry, Washington
University School of Medicine, St. Louis, MO, USA

Eco de Geus Department of Biological Psychology,
VU University, Amsterdam, The Netherlands

Mary Kate Elfrey Department of Medicine, Johns Hopkins
Bayview Medical Center, Baltimore, MD, USA

Kenneth E. Freedland Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

Alexander H. Glassman Department of Clinical
Psychopharmacology, New York State Psychiatric Institute,
New York, NY, USA and Department of Psychiatry, Columbia
University College of Physicians and Surgeons, New York, NY, USA

Wei Jiang Department of Psychiatry and Behavioral Sciences,
Department of Medicine, Duke South Hospital, Durham, NC, USA

Palmiero Monteleone Department of Psychiatry, University of
Naples SUN, Naples, Italy

Glen L. Xiong Department of Psychiatry and Behavioral Sciences,
Department of Medicine, University of California, Davis, CA, USA

Roy C. Ziegelstein Department of Medicine, Johns
Hopkins Bayview Medical Center, Baltimore, MD, USA

Preface

The idea that depression is related to cardiac morbidity and death has been prevalent for hundreds of years. Although intuitively appealing, it has been scientifically difficult to prove. Both the existence of the association and the mechanisms behind the association have proven much more complicated than might have been expected. This book examines the evidence that the association exists, the various mechanisms that might underlie the association and our ability to treat depression in the face of cardiovascular disease.

Drs Jiang and Xiong review in their chapter the epidemiology of the comorbidity between depression and heart disease. Extensive epidemio-logical data is now available, but the interpretation of the data is complicated by the need to control for cardiac risk factors and medications that might be used to treat depression. Cigarette smoking is an example of a cardiac risk factor that is also known to be seen more frequently in depressed patients. From the perspective of depressed patients, it matters little if their risk for cardiac disease comes from cigarette smoking or is directly related to depression. However, this is an important distinction in any scientific understanding of the mechanisms creating the association.