Darren K McGuire - Diabetes in Cardiovascular Disease: Expert Consult - Online

First Edition

Darren K. McGuire, MD, MHSc, FAHA, FACC

Professor of Internal Medicine, Dallas Heart Ball Chair for Research on Heart Disease in Women

Director, Parkland Hospital and Health System Cardiology Clinics, University of Texas Southwestern Medical Center, Dallas, Texas

Nikolaus Marx, MD, FAHA

Professor of Medicine/Cardiology, Head of Department of Internal Medicine I, University Hospital Aachen, Aachen, Germany

1600 John F. Kennedy Blvd.

Ste 1800

Philadelphia, PA 19103-2899

DIABETES IN CARDIOVASCULAR DISEASE: A COMPANION TO BRAUNWALDS HEART DISEASE

ISBN: 978-1-4557-5418-2

Copyright 2015 by Saunders, an imprint of Elsevier Inc.

All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publishers permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions.

This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).

Notices

Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.

Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.

With respect to any drug or pharmaceutical products identified, readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of practitioners, relying on their own experience and knowledge of their patients, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions.

To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.

Library of Congress Cataloging-in-Publication Data

Diabetes in cardiovascular disease: a companion to Braunwald's heart disease / [edited by] Darren K. McGuire, Nikolaus Marx.

p.; cm.

Complemented by: Braunwald's heart disease / edited by Robert O. Bonow ... [et al.]. 9th ed. 2012.

Includes bibliographical references and index.

ISBN 978-1-4557-5418-2 (hardcover: alk. paper)

I. McGuire, Darren K., editor. II. Marx, Nikolaus (Professor of medicine/cardiology), editor. III. Braunwald's heart disease. Complemented by (work):

[DNLM: 1. Cardiovascular Diseases--complications. 2. Diabetes Complications. 3. Diabetes Mellitus--physiopathology.

4. Diabetes Mellitus--therapy. 5. Risk Factors. WG 120]

RC681

616.1'2--dc23

2014012925

Executive Content Strategist: Dolores Meloni

Content Development Specialist: Angela Rufino

Publishing Services Manager: Anne Altepeter

Project Manager: Cindy Thoms

Design Manager: Steven Stave

Illustrations Manager: Lesley Frazier

Printed in China

Last digit is the print number: 9 8 7 6 5 4 3 2 1

To my wife, Julia, and our children, Emma and Jack, for their support, encouragement, and sacrifices for the time and effort required to develop this book. Thanks to each of you for keeping me focused on what is really most important, always.

To the patients around the world afflicted with diabetes, with hopes of an increasingly bright future.

Darren K. McGuire

To Nicole, and to my children, Nadine, Julian, and Florian, for their remarkable support through this endeavor.

In memory of my father Hans-Albert.

Nikolaus Marx

David Aguilar, MD Assistant Professor of Medicine, Internal Medicine and Cardiology, Baylor College of Medicine, Houston, Texas

Sylvie A. Ahn, MD Division of Cardiology, Cliniques Universitaires St-Luc, Ple de Recherche Cardiovasculaire, Institut de Recherche Exprimentale et Clinique (IREC)Universit Catholique de Louvain, Brussels, Belgium

Pavan K. Battiprolu, PhD Departments of Internal Medicine, Cardiology, and Metabolic Disorders, University of Texas Southwestern Medical Center, Dallas, Texas

Joshua A. Beckman, MD, MS Associate Professor of Medicine, Harvard Medical School, Director, Cardiovascular Fellowship Program, Cardiovascular Division, Brigham and Womens Hospital, Boston, Massachusetts

Deepak L. Bhatt, MD, MPH Executive Director of Interventional Cardiovascular Programs, Brigham and Womens Hospital Heart and Vascular Center, Senior Physician, Brigham and Womens Hospital, Senior Investigator, TIMI Study Group, Boston, Massachusetts

Petter Bjornstad, MD Department of Pediatrics, Childrens Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado

Jonathan D. Brown, MD Instructor, Harvard Medical School, Cardiovascular Division, Brigham and Womens Hospital, Boston, Massachusetts

Melanie J. Davies, MD, PhD Diabetes Research Centre, College of Medicine, Biological Sciences and Psychology, University of Leicester, Leicester, United Kingdom

Robert H. Eckel, MD Professor of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado

Leonard E. Egede, MD, MS Professor of Medicine, Health Equity and Rural Outreach Innovation Center, Ralph H. Johnson Department of Veterans Affairs Medical Center, Center for Health Disparities Research, Division of General Internal Medicine, Medical University of South Carolina, Charleston, South Carolina

Frank Joachim Erbguth, MD, PhD Professor of Neurology, Department of Neurology, Nuremberg Municipal Academic Hospital, Nuremberg, Germany

Jason S. Fish, MD, MSHS Director of Ambulatory Quality and Optimization, Assistant Professor, Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas

B. Miles Fisher, MD, MB ChB Consultant Physician, Glasgow Royal Infirmary, Honorary Professor, University of Glasgow, Glasgow, Scotland