Jarman Andrew P. - Building brains an introduction to neural development

1. Chapter 02

1. Chapter 01
2. Chapter 02
3. Chapter 03
4. Chapter 04
5. Chapter 05
6. Chapter 06
7. Chapter 07
8. Chapter 08
9. Chapter 09
10. Chapter 10
11. Chapter 11
12. Chapter 12

David J. Price, Andrew P. Jarman, John O. Mason and Peter C. Kind

Centre for Integrative Physiology
University of Edinburgh
UK

This Work is a co-publication between New York Academy of Sciences and John Wiley & Sons Ltd.

This edition first published 2018
2018 John Wiley & Sons Ltd

First edition published 2011 by John Wiley & Sons Ltd

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Library of Congress CataloginginPublication Data

Names: Price, David J., 1957 November 20 author. | Jarman, Andrew (Andrew P.), author. | Mason, John O. (Reader in developmental neurobiology), author. | Kind, Peter (Peter C.), author.
Title: Building brains : an introduction to neural development / David J. Price, Andrew P. Jarman, John O. Mason and Peter C. Kind.
Description: Second edition. | Hoboken, NJ : Wiley, 2018. | Preceded by: Building brains / David Price ... [et al.]. 2011. | Includes bibliographical references and index. |
Identifiers: LCCN 2017024240 (print) | LCCN 2017026722 (ebook) | ISBN 9781119293910 (pdf) | ISBN 9781119293712 (epub) | ISBN 9781119293880 (paperback)
Subjects: | MESH: Neuronsphysiology | Nervous Systemanatomy & histology | Neurogenesis
Classification: LCC QP363.5 (ebook) | LCC QP363.5 (print) | NLM WL 102.5 | DDC 612.8dc23
LC record available at https://lccn.loc.gov/2017024240

Cover Design: Wiley
Cover Image: Created by David J. Price

Many important conceptual and technical advances have improved our understanding of nervous system development over the 6 years that have elapsed since we completed the first edition of Building Brains. In this second edition, we have updated the book to include recent conceptual breakthroughs in specific areas and we have added new descriptions of major technical developments that are likely to have a huge impact in the future. Technical advances include our ability to sequence, rapidly and efficiently, entire genomes and transcriptomes, telling us much more about the genetic control of both normal and abnormal development. Vast quantities of data on the genomes and transcriptomes of normal and abnormal organisms, tissues and cells are becoming available on public databases where they can be analysed by the scientific community using new computational methods. In this second edition, we explain these advances and we stress their potential to enhance our understanding of human development and disease. We complement this with more background on how the human nervous system develops and we draw out the similarities and differences between neural development in humans and other species. We include descriptions of new approaches using human cells in culture, for example to generate brainlike structures in which mechanisms of normal and abnormal development can be modelled and analysed. Advances in transgenic methods, including those for generating mutations in specific cells at specific times, have had a major impact on our ability to understand the molecular mechanisms of development both in human cells and in model organisms. We explain these methods and the opportunities they offer to the experimentalist. We hope that these additions will not only increase the usefulness of our book but will also convey the sense of excitement felt by those of us working in this field. The opportunities to make major contributions to solving the profound mysteries of normal and disordered brain development have never been greater.

We have also taken this opportunity to improve the clarity of aspects of the book that readers found difficult in the first edition. We are grateful to all of you who have given us suggestions and pointed out errors. We thank the undergraduate students taking our course at Edinburgh, who offered extensive feedback. In particular, Natasha Anstey gave detailed comments far beyond our expectations thank you! We also thank Natasha Price for helping us make movies explaining trickier topics (you can use the QR codes in to find them on the companion website) and for original drawings of some organisms used in . We are indebted to all at Wiley who helped produce this book, in particular Mindy OkuraMarszycki, Rebecca Ralf and Ramprasad Jayakumar.

David J. Price
Andrew P. Jarman
John O. Mason
Peter C. Kind