Murphy Kenneth M. - Janeways Immunobiology (9780393884678)

Since early 2020, the field of immunology has moved to an unexpectedly prominent place in daily life. As SARS-CoV-2 spread around the globe, basic questions about how the immune system combats viruses moved into the forefront of public attention. Why were individual responses to the virus so variable? Why were outcomes in older patients so much more dire than in younger infected individuals? And, most important, how quickly would a vaccine be available, would it provide adequate protection, and for how long? While some questions have been answered, notably observing the most rapid vaccine development in human history, many other questions remain outstanding. Clearly, the need for continued research into basic mechanisms controlling human immunity is undeniable.

Though somewhat overshadowed during the COVID-19 pandemic, there has been a dramatic rise in the use of various other immunotherapies in the years since the last edition of Janeways Immunobiology. Multiple methods for manipulating immune responses have significantly altered the practice of clinical medicine, benefiting patients who present with a diagnosis of cancer, autoimmune disease, or chronic inflammatory disorder. In large part, these clinical advances arose from decades of basic research aimed at uncovering the molecules and pathways that regulate immune cells at steady-state conditions or during infection, inflammation, or autoimmunity.

This Tenth Edition of Janeways Immunobiology strives to carry on Charlie Janeways legacy of providing a comprehensive, up-to-date textbook focused on the mechanisms underlying the responses to infection. In keeping with this mission, this editions text and figures have been updated throughout. The immune response to SARS-CoV-2 and the multiple vaccine strategies utilized against this infection are introduced in is a new description of an analytic technique used to measure antibody responses to SARS-CoV-2 in infected or vaccinated individuals. End-of-chapter study questions have been reworked in the Tenth Edition, and an online learning platform for student self-assessment, InQuizitive, has been created.

We have benefited greatly from the major contribution of Gregory Barton, an expert in innate immune signaling, who has revised and updated . Many additional people deserve special thanks, including our thoughtful colleagues who reviewed the Ninth Edition and provided insights that helped direct revisions in this new edition. We benefited from the eagle-eyed accuracy reviewers who provided feedback on Tenth Edition chapters. All of these individuals are cited in the Acknowledgments section, and we express our gratitude for their efforts.

We have the good fortune to work with an outstanding editorial group at W. W. Norton. We thank Denise Schanck, our editorial advisor, who coordinated the entire project, guiding us gently but firmly back on track throughout the process. We thank Betsy Twitchell, our editor, who contributed her guidance, support, and wisdom. Sincere thanks also go to Judith Kromm, our developmental editor, and Christopher Curioli, our copyeditor, for their insights and attention to detail. As in all previous editions, Matt McClements has contributed his geniusand patiencereinterpreting the authors sketches into elegant illustrations. Our editing, production, and permissions teams provided their expertise throughout; they are Maggie Stephens, David Bradley, Ben Reynolds, Stephanie Romeo, and Patricia Wong. Our media experts, Kate Brayton, Jasmine Ribeaux, Alexandra Malakhoff, and Kara Zaborowsky, created our excellent supplements package. The authors wish to thank their most important partnersTheresa, Cindy Lou, and Charlescolleagues in life who have supported this effort with their generosity of time, their own editorial insights, and their infinite patience.

We hope this Tenth Edition will continue to inspire students to appreciate immunologys beautiful subtletyjust as Charlie did. We encourage all readers to share with us their views on where we have come up short, so the next edition will further approach the asymptote. Happy reading and learning!

Kenneth Murphy

Casey Weaver

Leslie Berg

Whats New in the Tenth Edition

New Coauthor

Janeways Immunobiology is the premier text for immunology, giving students at all levels a current and authoritative understanding of immunology research. Leslie Berg joins Ken Murphy and Casey Weaver in comprehensively updating the textbook.

New Online Assessment in InQuizitive

InQuizitive for Janeways Immunobiology is an award-winning, adaptive learning tool that gives students personalized learning pathways as they work through the material. Through a variety of question types and answer-specific feedback, students learn the necessary vocabulary to succeed in the immunology course and practice applying that vocabulary to core concepts.