Institute of Laboratory Animal Resources (U.S.). Committee - Immunodeficient rodents: a guide to their immunobiology, husbandry, and use

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title	:	Immunodeficient Rodents : A Guide to Their Immunobiology, Husbandry, and Use
author	:
publisher	:	National Academies Press
isbn10 | asin	:	0309037964
print isbn13	:	9780309037969
ebook isbn13	:	9780585028798
language	:	English
subject	Immunological deficiency syndromes--Animal models, Rodents--Immunology, Rodents as laboratory animals.
publication date	:	1989
lcc	:	RC606.I485 1989eb
ddc	:	599.32/30429
subject	:	Immunological deficiency syndromes--Animal models, Rodents--Immunology, Rodents as laboratory animals.

Immunodeficient Rodents A Guide to Their Immunobiology, Husbandry, and Use Committee on Immunologically Compromised Rodents Institute of Laboratory Animal Resources Commission on Life Sciences National Research Council NATIONAL ACADEMY PRESS Washington, D.C. 1989

NATIONAL ACADEMY PRESS 2101 Constitution Avenue, NW Washington, DC 20418 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, National Academy of Engineering, and Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance. This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, National Academy of Engineering, and Institute of Medicine. The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Frank Press is president of the National Academy of Sciences. The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. Robert M. White is president of the National Academy of Engineering. The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and upon its own initiative to identify issues of medical care, research, and education. Dr. Samuel O. Thier is president of the Institute of Medicine. The National Research Council was established by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy's purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and National Academy of Engineering in the conduct of their services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Frank Press and Dr. Robert M. White are chairman and vice-chairman, respectively, of the National Research Council. This project was funded primarily by the U.S. Department of Health and Human Services (DHHS) through contract number NO1-CM-57644 with the National Cancer Institute. Additional funding was provided by the National Science Foundation (NSF) through grant number BSR-8716373. Any opinions, findings, and conclusions or recommendations expressed in this publication are those of the committee and do not necessarily reflect the views of DHHS or NSF, nor does the mention of trade names, commercial products, or organizations imply endorsement by the U.S. government. Library of Congress Catalog Card No. 89-12387 ISBN 0-309-03796-4 Copyright 1989 by the National Academy of Sciences Printed in the United States of America

Page iii Committee on Immunologically Compromised Rodents Fred W. Quimby (Chairman), Center for Research Animal Resources, New York State College of Veterinary Medicine, Cornell University Melvin J. Bosma, Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania Robert A. Good, All Childrens Hospital, St. Petersburg, Florida Carl T. Hansen, Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland David D. Myers, Research Animal Resources Center, Memorial Sloan-Kettering Cancer Center, New York, New York Conrad B. Richter, Division of Laboratory Animal Medicine, Duke University Medical Center John B. Roths, The Jackson Laboratory, Bar Harbor, Maine Henry H. Wortis, Department of Pathology, Tufts University School of Medicine Invited Participants David E. Briles, The University of Alabama at Birmingham Muriel T. Davisson, The Jackson Laboratory, Bar Harbor, Maine Gabriel Fernandes, University of Texas Health Science Center, San Antonio Margaret C. Green, Emeritus, The Jackson Laboratory, Bar Harbor, Maine Dennis L. Guberski, University of Massachusetts Medical School

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