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Robert Morfin - DHEA and the Brain (Nutrition, Brain, and Behavior)

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DHEA and the Brain reviews a range of existing studies regarding DHEA administration to animals and humans. Chapter authors evaluate DHEA metabolism in tissues and organs, explore DHEA effects in the liver that may be of importance to the brain, and discuss recent findings regarding how DHEA is made in the brain. New perspectives about the neuroprotective effects of DHEA are presented, as well as insight related to DHEA metabolism in the brain.A number of health benefits have been associated with dehydroepiandrosterone (DHEA), including anti-cancer, anti-osteoporosis, anti-atherosclerosis, anti-diabetes, immuno-stimulating, and memory-enhancing effects. This has prompted millions of people to take this hormone as a daily nutritional supplement. However, there is some concern that prolonged self-administration may result in future health problems, as well as unease about potential side effects due to the production of steroid derivatives in the tissues.Featuring an esteemed panel of contributors, this volume provides an authoritative overview of the research concerning DHEA and the brain. It presents a variety of innovative approaches and ideas for future investigations into the physiological actions of this hormone.

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title DHEA and the Brain Nutrition Brain and Behavior V 1 author - photo 1
title:DHEA and the Brain Nutrition, Brain, and Behavior ; V. 1
author:Morfin, Robert.
publisher:CRC Press
isbn10 | asin:
print isbn13:9780203355459
ebook isbn13:9780203301210
language:English
subjectDehydroepiandrosterone, Dehydroepiandrosterone--Physiological effect, Dehydroepiandrosterone--metabolism, Dehydroepiandrosterone--physiology, Brain--drug effects, Brain Chemistry, Nootropic Agents, Receptors, Steroid--agonists.
publication date:2002
lcc:RM296.5.D45D49x 2002eb
ddc:615.78
subject:Dehydroepiandrosterone, Dehydroepiandrosterone--Physiological effect, Dehydroepiandrosterone--metabolism, Dehydroepiandrosterone--physiology, Brain--drug effects, Brain Chemistry, Nootropic Agents, Receptors, Steroid--agonists.

Page i

DHEA and the Brain

Page ii

Nutrition, brain and behaviour

Edited by Chandan Prasad, PhD

Professor and Vice Chairman (Research)

Department of Medicine

LSU Health Sciences Center

New Orleans, LA, USA

Series Editorial Advisory Board

Janina R.Galler, MD

Director and Professor of Psychiatry and Public Health

Center for Behavioral Development and Mental Retardation

Boston University School of Medicine

Boston, MA, USA

R.C.A.Guedes, MD, Phd

Departmento de Nutrio

Centro de Cincias Da Sade

Universidade Federal de Pernambuco

Recife/PE, BRASIL

Gerald Huether, PhD

Department of Psychiatric Medicine

Georg-August-Universitt Gttingen

D-37075 Gttingen, Germany

Abba J.Kastin, MD, DSc

Editor-in-chief, PEPTIDES

Endocrinology Section,

Medical Service, V.A. Medical Center,

1601 Perdido Street,

New Orleans, LA, USA

H.R.Lieberman, PhD

Military Performance and Neuroscience Division,

USARIEM

Natick, MA, USA

Page iii

DHEA and the Brain

Edited by

Robert Morfin

Laboratoire de Biotechnologie
Conservatoire National des Arts et Mtiers
Paris, France

DHEA and the Brain Nutrition Brain and Behavior - image 2

London and New York

Page iv

First published 2002
by Taylor & Francis
11 New Fetter Lane, London EC4P 4EE

Simultaneously published in the USA and Canada
by Taylor & Francis Inc,
29 West 35th Street, New York, NY 10001

Taylor & Francis is an imprint of the Toylor & Francis Group

This edition published in the Taylor & Francis e-Library, 2004.

2002 Taylor & Francis

All rights reserved. No part of this book may be reprinted or reproduced
or utilized in any form or by any electronic, mechanical, or other means,
now known or hereafter invented, including photocopying and recording,
or in any information storage or retrieval system, without permission in
writing from the publishers.

Every effort has been made to ensure that the advice and information in this book
are true and accurate at the time of going to press. However, neither the publisher
nor the authors can accept any legal responsibility or liability for any errors or
omissions that may be made. In the case of drug administration, any medical
procedure or the use of technical equipment mentioned within this book,
you are strongly advised to consult the manufacturers guidelines.

British Library Cataloguing in Publication Data
A catalogue record for this book is available
from the British Library

Library of Congress Cataloging in Publication Data
A catalog record has been requested

ISBN 0-203-30121-8 Master e-book ISBN

ISBN 0-203-35545-8 (OEB Format)

ISBN 0-415-27585-7 (Print Edition)

Page v

Contents

List of contributors

vii

Series preface

xi

Preface

xiii

The brain, a putative source and target of DHEA
MARIA LUISA BARBACCIA AND TATIANA SIDIROPOULOU

DHEA metabolites during the life span
RICHARD HAMPL, MARTIN HILL AND LUBOSLAV STRKA

Postulated roles of DHEA in the decline of neural function with age
L.-Y.NGAI AND J.HERBERT

DHEA: hormone of youth and resiliencestill a maverick
MARIA DOROTA MAJEWSKA

DHEA effects on liver
DORIS MAYER

DHEA and brain development
SYNTHIA H.MELLON

DHEA metabolism in the brain: production and effects of the 7-hydroxylated derivative
M.TRINCAL, J.LOEPER, D.POMPON, J.J.HAUW AND R.MORFIN

DHEA: biosynthesis, regulation and function in the central nervous system
RACHEL C.BROWN, YING LIU AND VASSILIOS PAPADOPOULOS

Page vi

Cross-talk between DHEA and neuropeptides
CHANDAN PRASAD

DHEA effects on human behavior and psychiatric illness
VICTOR I.REUS AND OWEN M.WOLKOWITZ

Effects of DHEA on diabetes mellitus
KAZUTAKA AOKI AND HISAHIKO SEKIHARA

The clinicians view of DHEA: an overview
FRANK SVEC

DHEA replacement and cognition in healthy elderly humans A summary of results from placebo controlled experiments
OLIVER T.WOLF AND CLEMENS KIRSCHBAUM

Index

Page vii

Contributors

Kazutaka Aoki

The Third Department of Internal Medicine

Yokohama City University School of Medicine

39 Fuku-ura Kanazawa-ku

Yokohama 236-0004

Japan

Maria Luisa Barbaccia

Department of Neuroscience

University of Rome Tor Vergata

Edificio F-sud- Via Tor Vergata

00133-Rome-Italy

Rachel C.Brown

Interdisciplinary Program in Neuroscience

Georgetown University School of Medicine

3900 Reservoir Rd. NW

Washington, DC 20007

Richard Hampl

Institute of Endocrinology

2 Nrodn, 116 94 Praha

Czech Republic

J.J.Hauw

Service de Neuropathologie

Raymond Escourolle

Groupe Hospitalier Piti-Slaptrire

4783 Boulevard de lHpital

75651 Paris Cedex 13

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