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National Research Council - REVIEW OF THE U.S. NAVY ENVIRONMENTAL HEALTH CENTER’S HEALTH-HAZARD ASSESSMENT PROCESS

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REVIEW OF THE U.S. NAVY ENVIRONMENTAL HEALTH CENTERS HEALTH-HAZARD ASSESSMENT PROCESS

Subcommittee on Toxicological Hazard and Risk Assessment

Committee on Toxicology

Board on Environmental Studies and Toxicology

Commission on Life Sciences

National Research Council

NATIONAL ACADEMY PRESS

Washington, D.C.

NATIONAL ACADEMY PRESS
2101 Constitution Ave., N.W.
Washington, D.C.20418

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This project was supported by Contract Nos. DAMD17-89-C-9086 and DAMD17-99-C-9049 between the National Academy of Sciences and U.S. Army. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the organizations or agencies that provided support for this project.

ISBN 0-309-18375-8 e-pub ISBN

International Standard Book Number 0-309-07147-X

Additional copies of this report are available from:

National Academy Press 2101 Constitution Ave., NWBox 285 Washington, DC 20055

800-624-6242202-334-3313 (in the Washington metropolitan area)
http://www.nap.edu

Copyright 2000 by the National Academy of Sciences. All rights reserved.
Printed in the United States of America


Review of the U.S. Navy Environmental Health Centers Health-Hazard Assessment Process

THE NATIONAL ACADEMIES

National Academy of Sciences

National Academy of Engineering

Institute of Medicine

National Research Council

The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Bruce M. Alberts is president of the National Academy of Sciences.

The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. William A. Wulf is president of the National Academy of Engineering.

The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Kenneth I. Shine is president of the Institute of Medicine.

The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academys purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Bruce M. Alberts and Dr. William A. Wulf are chairman and vice chairman, respectively, of the National Research Council.

Subcommittee on Toxicological Hazard and Risk Assessment

ROGENEHENDERSON

(CHAIR),

Lovelace Respiratory Research Institute, Albuquerque, New Mexico

GERMAINE M. BUCK,

University at Buffalo, State of New York

JACK H. DEAN,

Sanofi-Synthelabo, Inc., Malvern, Pennsylvania

KEVIN E. DRISCOLL,

Proctor and Gamble Pharmaceuticals, Cincinnati, Ohio

DAVID W. GAYLOR,

U.S. Food and Drug Administration, Jefferson, Arkansas

JUDITH A. GRAHAM,

U.S. Environmental Protection Agency, Research Triangle Park, North Carolina

JOHN L. ODONOGHUE,

Eastman Kodak Company, Rochester, New York

ROBERT SNYDER,

Rutgers University, Piscataway, New Jersey

BERNARD M. WAGNER,

Consultant,

Short Hills, New Jersey

ANNETTA P. WATSON,

Oak Ridge National Laboratory, Oak Ridge, Tennessee

HANSPETER R. WITSCHI,

University of California, Davis, California

Staff

KULBIR S. BAKSHI,

Project Director

ROBERT J. CROSSGROVE,

Editor

MIRSADA KARALIC-LONCAREVIC,

Information Specialist

TANYA LEE,

Acting Project Assistant

Sponsor

U.S. DEPARTMENTOF DEFENSE

COMMITTEE ON TOXICOLOGY

BAILUS WALKER, JR.

(Chair),

Howard University Medical Center and American Public Health Association, Washington, D.C.

MELVIN E. ANDERSEN,

Colorado State University, Denver, Colorado

GERMAINE M. BUCK,

University at Buffalo, State of New York

ROBERT E. FORSTER II,

University of Pennsylvania, Philadelphia, Pennsylvania

PAUL M.D. FOSTER,

Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina

WILLIAM E. HALPERIN,

National Institute for Occupational Safety and Health, Cincinnati, Ohio

CHARLES H. HOBBS,

Lovelace Respiratory Research Institute and Lovelace Biomedical and Environmental Research Institute, Albuquerque, New Mexico

SAM KACEW,

Department of Pharmacology Faculty of Medicine and University of Ottawa, Ontario,Canada

NANCY KERKVLIET,

Oregon State University, Agricultural and Life Sciences, Corvallis, Oregon

FLORENCE K. KINOSHITA,

Hercules Incorporated, Wilmington, Delaware

MICHAEL J. KOSNETT,

University of Colorado Health Sciences Center, Denver, Colorado

MORTON LIPPMANN,

New York University School of Medicine, Tuxedo, New York

ERNEST E. MCCONNELL,

ToxPath, Inc., Raleigh, North Carolina

THOMAS E. MCKONE,

Lawrence Berkeley National Laboratory and University of California, Berkeley, California

HARIHARA MEHENDALE,

The University of Louisiana at Monroe, Monroe, Louisiana

DAVID H. MOORE,

Battelle Memorial Institute, Bel Air, Maryland

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