National Research Council (U.S.). Committee on Human Genome - Evaluating human genetic diversity

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title	:	Evaluating Human Genetic Diversity
author	:
publisher	:	National Academies Press
isbn10 | asin	:	0309059313
print isbn13	:	9780309059312
ebook isbn13	:	9780585002262
language	:	English
subject	Human genetics--Variation.
publication date	:	1997
lcc	:	QH431.E845 1997eb
ddc	:	599.93/5
subject	:	Human genetics--Variation.

Evaluating Human Genetic Diversity Committee on Human Genome Diversity Commission on Life Sciences NATIONAL RESEARCH COUNCIL NATIONAL ACADEMY PRESS Washington, DC 1997

Page ii NATIONAL ACADEMY PRESS 2101 Constitution Ave., N.W. Washington, D.C. 20418 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance. In preparing its report, the committee invited people with different perspectives to present their views. Such invitation does not imply endorsement of those views. This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. This study by the National Research Council's Commission on Life Sciences was sponsored by the National Institutes of Health and the National Science Foundation under contract no. N01-OD-4-2139. Points of view in this document are those of the authors and do not necessarily represent the official position of the sponsoring agencies. Library of Congress Catalog Card Number 97-81059 International Standard Book Number 0-309-05931-3 Additional copies of this report are available from: National Academy Press 2101 Constitution Ave., NW Box 285 Washington, DC 20055 800-624-6242 202-334-3313 (in the Washington Metropolitan Area) http://www.nap.edu Copyright 1997 by the National Academy of Sciences. All rights reserved. Printed in the United States of America

Page iii COMMITTEE ON HUMAN GENOME DIVERSITY WILLIAM J. SCHULL (Chair) University of Texas Health Center, Houston, TX GEORGE J. ANNAS, Boston University Schools of Medicine and Public Health, Boston, MA NORMAN ARNHEIM, University of Southern California, Los Angeles, CA JOHN BLANGERO, Southwest Foundation for Biomedical Research, San Antonio, TX ARAVINDA CHAKRAVARTI, Case Western Reserve University, Cleveland, OH VIRGINIA R. DOMINGUEZ, University of Iowa, Iowa City, IA GEORGIA DUNSTON, Howard University, Washington, DC WARD H. GOODENOUGH, University of Pennsylvania, Philadelphia, PA RICHARD R. HUDSON, University of California, Irvine, CA ERIC JUENGST, Case Western Reserve University, Cleveland, OH MICHAEL M. KABACK, University of California, San Diego, CA DANIEL R. MASYS, University of California, San Diego, CA KATHRYN MOSELEY, Henry Ford Hospital, Detroit, MI ROBERT SOKAL, State University of New York, Stony Brook, NY ALAN R. TEMPLETON, Washington University, St. Louis, MO LAP-CHEE TSUI, The Hospital for Sick Children, Toronto, ON, Canada GEORGE C. WILLIAMS, State University of New York, Stony Brook, NY NRC Staff TANIA WILLIAMS, Study Director ERIC A. FISCHER, Study Director (through December 1996) NORMAN GROSSBLATT, Editor ERIKA SCHUGART, Research Assistant KATHLEEN BEIL, Project Assistant PAULETTE A. ADAMS, Senior Project Assistant (through August 1996)

Page iv BOARD ON BIOLOGY MICHAEL T. CLEGG (Chair) University of California, Riverside, CA JOHN C. AVISE, University of Georgia, Athens, GA DAVID EISENBERG, University of California, Los Angeles, CA GERALD D. FISCHBACH, Harvard Medical School, Cambridge, MA DAVID J. GALAS, Darwin Molecular Corporation, Bothell, WA DAVID GOEDDEL, Tularik, Incorporated, South San Francisco, CA ARTURO GOMEZ-POMPA, University of California, Riverside, CA COREY S. GOODMAN, University of California, Berkeley, CA BRUCE R. LEVIN, Emory University, Atlanta, GA OLGA F. LINARES, Smithsonian Tropical Research Institute, Panama ELLIOTT M. MEYEROWITZ, California Institute of Technology, Pasadena, CA ROBERT T. PAINE, University of Washington, Seattle, WA COREY S. GOODMAN, University of California, Berkeley, CA RONALD R. SEDEROFF, North Carolina State University, Raleigh, NC DANIEL SIMBERLOFF, Florida State University, Tallahassee, FL ROBERT R. SOKAL, State University of New York, Stony Brook, NY SHIRLEY TILGHMAN, Princeton University, Princeton, NJ RAYMOND L. WHITE, University of Utah, Salt Lake City, UT Staff PAUL GILMAN, Acting Director ERIC A. FISCHER, Director (through December 1996) TANIA WILLIAMS, Program Officer KATHLEEN BEIL, Administrative Assistant ERIKA SHUGART, Research Assistant

Page v COMMISSION ON LIFE SCIENCES THOMAS D. POLLARD (Chair) The Salk Institute for Biological Studies, La Jolla, CA FREDERICK R. ANDERSON, Cadwalader, Wickersham & Taft, Washington, DC JOHN C. BAILAR, III, University of Chicago, IL PAUL BERG, Stanford University, Stanford, CA JOANNA BURGER, Rutgers University, Piscataway, NJ SHARON L. DUNWOODY, University of Wisconsin, Madison, WI JOHN L. EMMERSON, Indianapolis, IA NEAL L. FIRST, University of Wisconsin, Madison, WI URSULA W. GOODENOUGH, Washington University, St. Louis, MO HENRY W. HEIKKINEN, University of Northern Colorado, Greeley, CO HANS J. KENDE, Michigan State University, East Lansing, MI CYNTHIA J. KENYON, University of California, San Francisco, CA DAVID M. LIVINGSTON, Dana-Farber Cancer Institute, Washington, DC DONALD R. MATTISON, University of Pittsburgh, Pittsburgh, PA JOSEPH E. MURRAY, Wellesley Hills, MA EDWARD E. PENHOET, Chiron Corporation, Emeryville, CA MALCOLM C. PIKE, Norris/USC Comprehensive Cancer Center, Los Angeles, CA JONATHAN M. SAMET, The Johns Hopkins University, Baltimore, MD CHARLES F. STEVENS, The Salk Institute for Biological Studies, La Jolla, CA JOHN L. VANDEBERG, Southwest Foundation for Biomedical Research, San Antonio, TX

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