Mansoor R. Mirza - Management of Endometrial Cancer
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- Book:Management of Endometrial Cancer
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- Year:2020
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This Springer imprint is published by the registered company Springer Nature Switzerland AG
The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
In all affairs its a healthy thing now and then to hang a question mark on the things you have long taken for granted.
Bertrand Russell (18721970)
Management of endometrial cancer has improved in the past decade. A gynaecologist or an oncologist managing these patients needs to have an update and broad knowledge of all aspects of disease, including epidemiology, tumour biology, diagnostics and deep knowledge of multidisciplinary treatment approaches.
For many decades, treatment of endometrial cancer was based on our beliefs, expert opinions and rather low level of evidence resulting in different treatment approaches depending upon the subspecialty to treat the patient. The level of evidence has improved lately, which was reflected by the first of its kind of consensus report involving all subspecialties.
More high-quality clinical trials are being performed to answer some of the fundamental questions regarding management of this disease, thus improving outcome of our patients. This book tries to capture advances in all fields, and I would like to thank all my colleagues for their great contribution. My special thanks to OvaCure, Ms. Adoracion Pegalajar-Jurado and Ms. Tina Koutouleas for their tremendous organisational support to bring this project to a reality.
I hope that this contribution will help our colleagues in their continuous effort to improve the outcome of our patients.
Endometrial cancer is the most common malignancy of the female genital tract in the more developed regions of the world []. Stage of disease, i.e., the extent of tumor spread at the time of presentation, is the most significant prognostic parameter.
The prognosis of endometrial cancer is generally good with a 5-year relative survival around 80% [].
The main purpose of cancer staging is to help clinicians predict the prognosis for a cancer patient, guide treatment planning, evaluate and compare treatment results, facilitate exchange of information between health professionals, and help in identifying clinical trials that may be appropriate for the patient. Cancer staging systems should be evidence-based and practical, which implies that changes will occur over time based on new knowledge.
The first cancer staging system was published in 1929 under the patronage of the League of Nations, and applied to carcinoma of the cervix uteri []. In 1958, the International Federation of Gynecology and Obstetrics , FIGO (Fdration Internationale de Gyncologie et dObsttrique), assumed the responsibility for supervising the staging of gynecological cancers as well as the patronage of publishing treatment results (the Annual Report on the Results of Treatment in Gynecological Cancer). The same year, FIGO developed the clinical staging system for carcinoma of the corpus uteri. In 1971, the grade of tumor was added as part of the staging.
FIGO surgical staging for Endometrial Carcinoma (2009)
FIGO stage | |
|---|---|
Ia | Tumor confined to the corpus uteri |
IAa | No or less than half myometrial invasion |
IBa | Invasion equal to or more than half of the myometrium |
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