The Endometrial Factor
A Reproductive Precision Medicine Approach
Edited by
Carlos Simn MD, PhD and
Linda C. Giudice MD, PhD
CRC Press
Taylor & Francis Group
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2017 by Taylor & Francis Group, LLC
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International Standard Book Number-13: 978-1-4987-4039-5 (Hardback)
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Library of Congress Cataloging-in-Publication Data
Simn, Carlos, editor ; Giudice, Linda, editor.
The endometrial factor : a reproductive precision medicine approach / edited by Carlos Simn, Linda C. Giudice.
Boca Raton, FL : CRC Press/Taylor & Francis Group, [2017]
Includes bibliographical references and index.
LCCN 2016041251| ISBN 9781498740395 (hardback : alk. paper) | ISBN 9781498740401 (ebook)
Subjects: | MESH: Uterine Diseases--diagnosis | Endometrium--physiopathology | Uterine Diseases--complications | Uterine Diseases--therapy
Classification: LCC RG316 | NLM WP 440 | DDC 618.1/4--dc23
LC record available at https://lccn.loc.gov/2016041251
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Preface
The relevance of the endometrial factor in reproductive medicine is gradually gaining momentum. The Endometrial Factor was carefully conceived with world experts to be a compendium of critically evaluated, state-of-the-art basic and clinical knowledge about the human endometrium that impacts or will impact clinical practice.
This new text updates the advances in the diagnosis and treatment of the uterine or endometrial factor in the management of the infertile patient in the context of precision medicine. is devoted to the description of all you need to know about the human endometrium, by Linda C. Giudice, coeditor of this book. It is followed by an update of diagnostic possibilities: noninvasive diagnosis using imaging, by Sanja Kupesic Plavsic; molecular diagnosis of endometrial receptivity, by Jose Miravet-Valenciano; molecular diagnosis of endometriosis, by Lusine Aghajanova; microbiological diagnosis of the human endometrial microbiomaendometritis, by Inmaculada Moreno; and invasive diagnosis through hysteroscopy, by Luk Rombauts.
focuses on specific reproductive and medical disorders and their clinical impact on the endometrial factor in a personalized manner. The endometrium is analyzed in polycystic ovary syndrome patients by Terhi T. Piltonen, in obesity by Ruth B. Lathi, in the presence of fibroids by Serdar Bulun and adenomyosis by Ivo Brosens.
updates current therapeutic options for the endometrial factor in a critical manner: from effects of classical hormonal treatments by Hugh S. Taylor and the management of dysfunctional uterine bleeding by Hilary Critchley, to immunological treatment by Mary Stephenson, analysis of empirical unproven treatments by Nick S. Macklon, and endometrial scratching by Claire Bourgain. New stem cell therapies in the atrophic endometrium and Ashermans syndrome are addressed by Hugh S. Taylor. Finally, we discuss what to do when the uterus is absent or not functional, including surrogacy by Molly Quinn and Heather Huddleston and uterine transplantation by Mats Brnnstrm.
addresses the ultimate function of the endometriummodulating and facilitating embryonic implantation. The interaction between the endometrium and the preimplantation embryo is presented by Felipe Vilella, and the establishment of pregnancy through different embryo transfer strategies by Siladitya Bhattacharya.
The book is introduced by the views of a pioneer, Peter A. W. Rogers, in pursuit of a better understanding of endometrial function on the hoped-for pathway to precision medicine.
We express our utmost appreciation to all of our international best-in-class colleagues who have graciously contributed to the realization of this publication; we are grateful for the time and effort they devoted. We hope that readers will find the contents of this book useful as a reference and a valuable tool for continued advancement in the understanding and management of the endometrial factor in reproductive medicine.
Carlos Simn and Linda C. Giudice
2016
Foreword: An eye to the future
Peter A. W. Rogers
The advent of in vitro fertilization (IVF) more than 35 years ago revolutionized reproductive medicine. While the goal was to treat infertile couples, the techniques that were developed generated a huge amount of new information on reproductive endocrinology, ovarian function, ovulation, fertilization, preimplantation embryology, implantation, and early pregnancy. This knowledge dividend from IVF continues today, as exemplified by chapters in this book covering advances in areas such as pelvic ultrasound, the impact of obesity on the endometrium, and the rapidly emerging field of the microbiome. The importance of this reproductive medicine research is brought sharply into focus by a recent analysis of data from the 2010 Global Burden of Disease Study (). This work reported a systematic analysis of years lived with disability (YLD) for 1160 sequelae of 289 diseases and injuries. Within the list, gynecological diseases contribute 146 YLD per 100,000 years, with major diseases being fibroids (44 YLD), polycystic ovary syndrome (40 YLD), genital prolapse (26 YLD), premenstrual syndrome (18 YLD), and endometriosis (8 YLD). To put this gynecological disability burden in perspective, the same study reports 161 YLD per 100,000 years for HIV/AIDS and tuberculosis combined, 99 YLD for Alzheimers and other dementias, and 55 YLD for rheumatoid arthritis. Most would agree that the investment by government into improving outcomes for gynecological diseases does not match that for these other higher-profile diseases with similar YLD impacts. This is an issue that requires ongoing lobbying of government by all patients, clinicians, and researchers with an interest in gynecological medicine. This book will help to raise awareness and understanding of these problems.
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