Chun-Feng Liu - Sleep Disorders in Parkinson’s Disease: Management and Case Study

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Sleep disorders are common non-motor manifestations in Parkinsons disease (PD). In China, the prevalence of PD patients with sleep disturbance ranges from 47.66 to 89.10%. Sleep disorders usually have a significant negative impact on quality of life and may also serve as markers to identify patients in the preclinical stage of PD.

There are different types of sleep disturbances in patients with PD such as insomnia, excessive daytime sleepiness, rapid eye movement sleep behavior disorders, restless legs syndrome, and sleep-disordered breathing. Because PD has a variety of clinical manifestations, sleep disorders are most easy to be overlooked. Standardized assessment and management of PD patients with sleep disturbances will be beneficial to improve the overall quality of diagnosis, treatment, and prognosis.

The past decade has witnessed major advances in the understanding of sleep physiology and pharmacology. However, sleep problems of PD have their unique characteristics, either related to disease itself or drugs. In order to provide a better understanding of the mechanisms that underlie sleep disorders in PD, we are pleased to invite very experienced and senior experts to convert this evidence intoManagement Recommendations on Sleep Disturbance of Patients with Parkinsons Disease. I am grateful to them for their hard work and for their expertise. However, considering that these recommendations into practice might have been problematic, many case reports in this book would make learning and understanding more visual, lifelike, and convenient.

This book aims to provide a comprehensive overview to advances of PD-related sleep disorders and give a practical guidance to clinicians and scientists on management of sleep disorders in PD, not merely scientists and clinicians, even to present a complete knowledge structure to the general population.

We also found that there was a lack of large clinical randomized controlled trials. We hope that this book will not only aid current treatment of the disease, but will also stimulate efforts to improve future management more quickly than has been possible to date.

This book is supported by National Key R&D Program of China (2017YFC0909100) and Jiangsu Provincial social development projects (BE2018658).