Alexander Birbrair - Tumor Microenvironment: Recent Advances

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This books initial title wasTumor Microenvironment. However, due to the current great interest in this topic, we were able to assemble more chapters than would fit in one book, covering tumor microenvironment biology from different perspectives. Therefore, the book was subdivided into several volumes.

This bookTumor Microenvironment: Recent Advancespresents contributions by expert researchers and clinicians in the multidisciplinary areas of medical and biological research. The chapters provide timely detailed overviews of recent advances in the field. This book describes the major contributions of different components of the tumor microenvironment during cancer development. Further insights into these mechanisms will have important implications for our understanding of cancer initiation, development, and progression. The authors focus on the modern methodologies and the leading-edge concepts in the field of cancer biology. In recent years, remarkable progress has been made in the identification and characterization of different components of the tumor microenvironment in several organs using state-of-the-art techniques. These advantages facilitated the identification of key targets and definition of the molecular basis of cancer progression within different tissues. Thus, this book is an attempt to describe the most recent developments in the area of tumor biology, which is one of the emergent hot topics in the field of molecular and cellular biology today. Here, we present a selected collection of detailed chapters on what we know so far about different aspects of the tumor microenvironment in various tissues. Ten chapters written by experts in the field summarize the present knowledge about distinct characteristics of the tumor microenvironment during cancer development.

Karen M. Bussard and colleagues from Thomas Jefferson University discuss novel techniques to study the bone-tumor microenvironment. Ryuji Yamaguchi and Guy Perkins from the University of California San Diego compare tumor microenvironments in mice and humans. Linda A. Buss and Gabi U. Dachs from the University of Otago describe the effects of exercise on the tumor microenvironment. Georgia A. Giotopoulou and Georgios T. Stathopoulos from the University of Patras update us with what we know about the effects of inhaled tobacco smoke on the pulmonary tumor microenvironment. Bastian Zinnhardt and colleagues from the University of Mnster address the importance of multimodal molecular imaging of the tumor microenvironment. Adi Karsch-Bluman and Ofra Benny from the Hebrew University of Jerusalem compile our understanding of necrosis in the tumor microenvironment and its role in cancer recurrence. Daolin Tang and colleagues from UT Southwestern Medical Center summarize current knowledge on the multifaceted effects of autophagy on the tumor microenvironment. David H. Gutmann from Washington University School of Medicine talks about the sociobiology of brain tumors. Christian Mnz from the University of Zrich focuses on the effect of -herpesviruses on the tumor microenvironment. Finally, Pter Bai and colleagues from the University of Debrecen give an overview of the microbiome as a component of the tumor microenvironment.

It is hoped that the articles published in this book will become a source of reference and inspiration for future research ideas. I would like to express my deep gratitude to my wife Veranika Ushakova and Mr. Murugesan Tamilselvan from Springer, who helped at every step of the execution of this project.