Baekelandt Veerle - Disease-Modifying Targets in Neurodegenerative Disorders

1. Tables in Chapter 3

1. Figures in Chapter 1
2. Figures in Chapter 2
3. Figures in Chapter 3
4. Figures in Chapter 4A
5. Figures in Chapter 4B
6. Figures in Chapter 5
7. Figures in Chapter 6
8. Figures in Chapter 7
9. Figures in Chapter 8
10. Figures in Chapter 9

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Matthew Bird , Institute of Neuroscience, Catholic University of Louvain, Brussels, Belgium

Christel Claes

KU Leuven Stem Cell Institute

VIB Center for the Biology of Disease, Leuven, Belgium

Mark R. Cookson , National Institute on Aging, National Institutes of Health, Bethesda, MD, United States

Marc Cruts

VIB Center of Molecular Neurology

Institute BornBunge, University of Antwerp, Antwerp, Belgium

Nicole Dglon

Neuroscience Research Center (CRN)

Lausanne University Hospital (CHUV), Lausanne, Switzerland

Marion Delenclos , Jacksonville, FL, United States

Ilse Dewachter , Research Group Physiology, University of Hasselt, Belgium

Richard Gordon , The University of Queensland, St. Lucia, QLD, Australia

Sarah Libbrecht , KU Leuven, Leuven, Belgium

Pamela J. McLean , Jacksonville, FL, United States

Ronald Melki , ParisSaclay Institute of Neuroscience, French National Center for Scientific Research, University of ParisSaclay, Gif-sur-Yvette, France

Simon Moussaud , Jacksonville, FL, United States

Tiago F. Outeiro

Institute of Molecular Medicine, University of Lisbon, Lisboa, Portugal

Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University Medical Center Goettingen, Goettingen, Germany

Wouter Peelaerts , KU Leuven, Leuven, Belgium

Kristel Sleegers

VIB Center of Molecular Neurology

Institute BornBunge, University of Antwerp, Antwerp, Belgium

Ilie-Cosmin Stancu , Institute of Neuroscience, Catholic University of Louvain, Brussels, Belgium

Joke Terryn

KU Leuven Stem Cell Institute

VIB Vesalius Research Center

University Hospitals Leuven, Leuven, Belgium

Dick Terwel , reMYND NV, Leuven, Belgium

Christine Van Broeckhoven

VIB Center of Molecular Neurology

Institute BornBunge, University of Antwerp, Antwerp, Belgium

Ludo Van Den Bosch

Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven

VIB, Center for Brain & Disease Research, Leuven, Belgium

Bruno Vasconcelos , Institute of Neuroscience, Catholic University of Louvain, Brussels, Belgium

Catherine M. Verfaillie , KU Leuven Stem Cell Institute, Leuven, Belgium

Eline Wauters

VIB Center of Molecular Neurology

Institute BornBunge, University of Antwerp, Antwerp, Belgium

Trent M. Woodruff , The University of Queensland, St. Lucia, QLD, Australia

Veerle Baekelandt, PhD, holds a Master of Romance Languages, a Master of Biology, and a PhD in Biology degrees at the Katholieke Universiteit Leuven. In 1992 she received a Frank Boas Fulbright scholarship for graduate study at Harvard University and became a research fellow in the Laboratory for Neuroscience Research headed by Dr. Larry Benowitz, Childrens Hospital, Harvard Medical School, Boston (19921993). In 1999 she joined as a postdoctoral fellow in a new gene therapy project for neurodegenerative diseases, which was the start of her own research group. In 2003 she was appointed as assistant professor at the KU Leuven and in 2007 as full-time research professor (BOF-ZAP). She is now head of the Laboratory for Neurobiology and Gene Therapy. Her research focuses on disease modeling and therapy for Parkinsons disease using viral vectors in cell culture and in vivo. The underlying rationale is that the generation of more relevant models in cells and in rodent brain will lead to a better insight into the molecular pathogenesis of PD and to the development of new therapeutic strategies and drugs.

Evy Lobbestael, PhD, obtained her Masters degree in biomedical sciences in the faculty of medicine at the KU Leuven (Belgium) in 2007. She received a PhD scholarship from the Research Foundation Flanders and did her PhD training in the laboratory for neurobiology and gene therapy at the KU Leuven under the supervision of Professor Baekelandt (2013). Her doctoral research focused on the function and dysfunction of the Parkinsons disease linked gene LRRK2 . Besides the development of multiple tools to study LRRK2 , which are currently used worldwide, she identified protein phosphatase 1 as a physiological regulator of cellular LRRK2 phosphorylation. Currently, she heads the LRRK2 group in the lab of Professor Baekelandt with a focus on LRRK2 signaling.