Jason Theodosakis M.D. M.S. M.P.H. - The Arthritis Cure: The Medical Miracle That Can Halt, Reverse, And May Even Cure Osteoarthritis

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Table of Contents

To my family for their patience and understanding, Jessica Galow for her support and motivation, Dr. Lisa Sumner for her editorial comments in the chapter on rheumatic diseases, Sheila Buff for being such a joy to work with, and Heather Jackson for constantly moving this project forward.

Jason Theodosakis, M.D., M.S., M.P.H., F.A.C.P.M., also known as Dr. Theo, is a practicing medical doctor. He is residency-trained, board-certified, and a Fellow in the specialty of preventive medicine. He is also fellowship-trained in Sports Medicine, a second specialty. His medical degree is from the University of Health Sciences/Chicago Medical School. He graduated summa cum laude with masters degrees in both Exercise and Sports Sciences and Public Health from the University of Arizona. His undergraduate education includes a double major (honors) in chemistry and biology from Florida International University.

Dr. Theodosakis divides his time between practicing clinical preventive medicine and sports medicine at the Canyon Ranch Medical Department, teaching, and volunteer activities. He is an assistant clinical professor at the University of Arizona College of Medicine and is the former director of the Universitys preventive medicine residency training program. He is on the oversight committee for the $16 million NIH trial on glucosamine and chondroitin and was named one of the worlds 14 greatest doctors by Rodale Press.

The original edition of his treatment program, The Arthritis Cure, resulted in a major paradigm shift in the way arthritis is treated. The Arthritis Cure is estimated to save thousands of deaths per year by reducing the need for dangerous medicines and surgery. Now some 40 clinical trials support his theories and millions worldwide successfully follow his program. Dr. Theodosakis is committed to maintaining the integrity of the programs principles, including quality control and quality assurance in the dietary supplement industry.

Dr. Theo can be contacted through his Web site at www.drtheo.com .

Sheila Buff is the author or coauthor of many books on health and nutrition, including The Good Fat, Bad Fat Counter, Dr. Atkins Age-Defying Diet, and The Complete Idiots Guide to Vitamins and Minerals. She lives in New Yorks Hudson Valley.

Chapter 1: Can Osteoarthritis Be Cured?

Centers for Disease Control, Prevalence of Disability and Associated Health ConditionsUnited States, 19911992. Mortality and Morbidity Weekly Review, 43(40), 1994, pages 730731, 737739.

Ibid.

Yelin, E. and Callahan, L. F. (National Arthritis Data Work Group), The Economic Costs and Social and Psychological Impact of Musculoskeletal Condition. Arthritis and Rheumatism, 38(10), 1995, pages 13511362.

Report in American College of Rheumatology 64th Annual Scientific Meeting. Arthritis and Rheumatism, 43(9 supplement), 2000, page S220.

McKenzie, L.S., Horsburgh, B. A., Ghosh, R., and Taylor, T.K.E., Osteoarthrosis: Uncertain Rationale for Anti-inflammatory Drug Therapy. Lancet, 1,1976, pages 908909.

Vidal y Plana, R. R., Bizzardi, D., and Rovati, A.L., Articular Cartilage Pharmacology: In Vitro Studies on Glucosamine and Nonsteroidal Anti-inflammatory Drugs. Pharmacological Research Communications, 10(6), 1978, pages 557569.

Palmoski, J. J., and Brandt, K.D., Effects of Some Non-steroidal Anti-inflammatory Drugs on Proteoglycan Metabolism and Organization in Canine Articular Cartilage. Arthritis and Rheumatism, 23, 1980, pages 10101020.

Felson, D. T., Zhang, Y., Hannan M. T., Risk Factors for Incident Radiographic Knee Osteoarthritis in the Elderly: The Framingham Study. Arthritis and Rheumatism, 40, 1997, pages 728733.

Lanyon, P., Muir, K., Doherty, S., and Doherty, M., Assessment of a Genetic Contribution to Osteoarthritis of the Hip: Sibling Study. British Medical Journal, 321, 2000, pages 11791183.

Griffin, M., et al., Practical Management of Osteoarthritis. Archives of Family Medicine, 4, December 1995, pages 10491055.

Swedberg, J.A., and Steinbauer, J.R., Osteoarthritis. American Family Physician, 45(2), February 1992, pages 557568.

Tsang, J.K., Update on Osteoarthritis. Canadian Family Physician, 36(614), 1990, pages 539544.

Lawrence, R.C., et al., Estimates of the Prevalence of Arthritis and Selected Musculoskeletal Disorders in the United States. Arthritis and Rheumatism, 41, 1998, pages 778799.

Liang, M. H., and Fortin, R., Management of Osteoarthritis of the Hip and Knee. Journal of the American Medical Association, 325 (2), 1991, pages 125127.

Adams, M. E., Cartilage Research and Treatment of Osteoarthritis. Current Opinions in Rheumatology, 4, 1992, pages 552559.

Chapter 2: When Joints Go Bad

Buckwalter, J.A., et al., Restoration of Injured or Degenerated Articular Cartilage. Journal of the American Academy of Orthopaedic Surgeons, 2(4), 1994, pages 192201.

Caplan, A.I., Cartilage. Scientific American, 251(l), October 1984, pages 8497.

Buckwalter, J.A., et al., Restoration of Injured or Degenerated Articular Cartilage. Journal of the American Academy of Orthopaedic Surgeons, 2(4), 1994, pages 192201.

Chapter 3: New Hope for Beating Osteoarthritis

Mueller-Fassbender, H., Bach, G.L., Haase, W., et al., Glucosamine Sulfate Compared to Ibuprofen in Osteoarthritis of the Knee. Osteoarthritis and Cartilage, 2, 1994, pages 6169.

Crolle, G., and DEste, E., Glucosamine Sulphate for the Management of Arthrosis: A Controlled Clinical Investigation. Current Medical Research and Opinion, 7(2), 1980, pages 104109.

Manicourt, D. H., Poilvache, P., Nzeusseu, A., et al., Serum Levels of Hyaluronan, Antigenic Keratan Sulfate, Matrix Metalloproteinase 3, andTissue Inhibitor of Metalloproteinases 1 Change Predictably in Rheumatoid Arthritis Patients Who Have Begun Activity after a Night of Bed Rest. Arthritis and Rheumatism, 42, 1999, pages 18611869.

Piperno, M., Reboul, P., Hellio le Graverand, M.P., et al., Osteoarthritic Cartilage Fibrillation Is Associated with a Decrease in Chondrocyte Adhesion to Fibronectin. Osteoarthritis and Cartilage, 6, 1998, pages 393399.

Meininger, M. A., Kelly, K.A., et al. Glucosamine Inhibits Inducible Nitric Oxide Synthesis. Biochemical and Biophysical Research Communications , 279(1), 2000, pages 234239.

Shikhman, A. R., Alaaeddine, A., and Lotz, M. K., N-Acetylglucosamine Prevents IL-1-Mediated Activation of Chondrocytes. Arthritis and Rheumatism, 42(9 suppl.), 1999, page S381.

Dovanti, A., Bignamini, A. A., and Rovati, A. L., Therapeutic Activity of Oral Glucosamine Sulphate in Osteoarthrosis: A Placebo-Controlled Double-Blind Investigation. Clinical Therapeutics, 3(4), 1980, pages 266272.

Pujalte, J. M., Llavore, E. P, and Ylescupidez, E. R. Double-Blind Clinical Evaluation of Oral Glucosamine Sulphate in the Basic Treatment of Osteoarthrosis. Current Medical Research and Opinion, 7(2), 1980, pages 110114.

Cordoba, F., and Nimni, M. E., Chondroitin Sulfate and Other Sulfates Containing Chondroprotective Agents May Exhibit Their Effects by Overcoming a Deficiency of Sulfur Amino Acids. Osteoarthritis and Cartilage, 11, 2003, pages 228230.

Fenton, J.I., Chlebek-Brown, K. A., Peters, T. L., et al., The Effects of Glucosamine Derivatives on Equine Articular Cartilage. Osteoarthritis and Cartilage, 8, 2000, pages 444451; Karzel, K., Domenjoz, R., Effect of Hexosamine Derivatives and Uronic Acid Derivatives on Glycosaminoglycan Metabolism of Fibroblast Cultures. Pharmacology, 5, 1971, pages 337345.

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