American Dental Association - ADA Dental Drug Handbook: A Quick Reference

The American Dental Associations Science Institute and the Department of Product Development and Sales developed this publication following a request by the ADA New Dentist Committee in 2015.

Principal contributions to this manuscript were made by Jay Elkareh, Pharm.D., Ph.D, Manager, Product Evaluation, Science Institute; Anita Mark, Senior Scientific Content Specialist, ADA Science Institute; Kathy Pulkrabek, Manager/Editor, Professional Products, Department of Product Development and Sales; and Carolyn Tatar, MBA, Senior Manager, Product Development and Sales at the American Dental Association.

External contributions to this manuscript were made by The ADA Dental Drug Handbook Editorial Advisory Panel: Sebastian Ciancio, DDS, MS, Director, Center for Clinical Dental Studies, and Adjunct Professor of Pharmacology, University at Buffalo School of Dental Medicine; Paul Eleazer, DDS, MS, Professor and Chair, Department of Endodontics, University of Alabama School of Dentistry; and Paul A. Moore, DMD, PhD, MPH, Professor, Pharmacology, Dental Anesthesiology and Dental Public Health, University of Pittsburgh School of Dental Medicine.

This book was designed by Lisa Empleo of Gray Cat Graphic Design.

2019 American Dental Association. All rights reserved. No part of this publication may be reproduced or transmitted, in any form or by any means, electronic or mechanical, including photocopying, recording, information storage and retrieval system, or otherwise, without the prior written permission of the American Dental Association. American Dental Association is a registered trademark.

The American Dental Association (ADA), the authors and editors (together the Publishers) publish and present the ADA Dental Drug Handbook to you. This handbook does not constitute policy of the ADA, establish a standard of care or restrict a dentists exercise of professional judgment. As the science of dental therapeutics evolves, changes in drug treatment and use become necessary. The reader is advised to consult the package insert for each drug to consider and adopt all safety precautions, before use, particularly with new and infrequently used drugs. The reader is responsible for ascertaining the U.S. Food and Drug Administration clearance of each drug and device used in his or her practice. Many of the proprietary names of the products listed in this book are trademarked and registered in the U.S. Patent Office. It should be understood that by making this material available, the Publishers are not advocating the use of any product described herein, nor are the Publishers responsible for misuse of a product due to typographical error. Additional information on any product may be obtained from the manufacturer.

Most of the chapters in the handbook will include drug monographs. These monographs give a broad pharmacological overview of the many drugs used in dentistry (e.g., drug interactions, adverse drug reactions, pharmacokinetics, contraindications, etc.). The clinical information has been compiled from various sources such as the U.S. Food & Drug Administration (www.fda.gov), Epocrates (www.epocrates.com), Lexicomp (online.lexi.com), Medscape (www.medscape.com). For a comprehensive drug profile, please refer to the previously mentioned websites or see the drug package insert.

Most of the monographs include a sample prescription. Clinicians are responsible to adjust the prescription dose, frequency and length of treatment based on the procedure performed, the medicine prescribed, and the patient condition, such as age, weight, metabolism, liver and renal function. The sample prescription in the handbook represents only a general recommendation by the authors based on scientific literature, and expert insights.

The Publishers have produced this handbook in their individual capacities and not on behalf or in the interest of any pharmaceutical companies or state or federal agencies. This handbook does not provide legal advice, and readers must consult with their own attorneys for such advice. The Publishers disclaim all responsibility for any liability, loss, injury or damage resulting directly or indirectly from the readers use and application of the information in this book and make no representations or warranties with respect to such information, including the products described herein.

| Dr. Kathleen Ziegler

| Dr. Jay Elkareh

| Dr. S. Craig Rhodes

| Dr. Paul Eleazer

| Dr. Elias Mikael Chatah

| Dr. Kathleen Ziegler

| Drs. Paul A. Moore and Elliot V. Hersh

| Dr. Elias Mikael Chatah

| Dr. Jay Elkareh

| Dr. Kathleen Ziegler

| Drs. Lakshmanan Suresh and Lida Radfar

| Mr. Louis Erazo

Drs. Martha Ann Keels and Erica Brecher

Dr. Jay Elkareh

Dr. Kathleen Ziegler

Dr. Jay Elkareh

Erica Brecher, DMD, MS

Assistant Professor, Department of Pediatric Dentistry

Virginia Commonwealth University School of Dentistry

Richmond, Virginia

Elias Mikael Chatah, DMD, B. Pharm, MS

Assistant Clinical Professor

Group Practice Leader

University of Connecticut School of Dental Medicine

Farmington, Connecticut

Sebastian Ciancio, DDS, MS

Distinguished Service Professor and Chair

Department of Periodontics & Endodontics

Adjunct Professor of Pharmacology

Director, Center for Clinical Dental Studies

University at Buffalo School of Dental Medicine

Buffalo, New York

Paul Eleazer, DDS, MS

Professor and Chair, Department of Endodontics

University of Alabama School of Dentistry

Birmingham, Alabama

Jay Elkareh, PharmD, PhD

Manager, Product Evaluation

Science Institute

American Dental Association

Chicago, Illinois

Louis Erazo, BS

Clinical Research Associate, Acceptance Program

Science Institute

American Dental Association

Chicago, Illinois

Elliot V. Hersh, DMD, MS, PhD

Professor, Oral Surgery and Pharmacology

Director, Division of Pharmacology and Clinical Therapeutics

University of Pennsylvania School of Dental Medicine

Philadelphia, Pennsylvania

Martha Ann Keels, DDS, PhD

Adjunct Professor in Pediatric Dentistry

University of North Carolina School of Dentistry

Associate Consulting Associate Professor in Surgery

Adjunct Associate Professor in Pediatrics

Duke University

Private Practice, Pediatric Dentistry

Durham, North Carolina

Paul A. Moore, DMD, PhD, MPH

Professor, Pharmacology, Dental

Anesthesiology and Dental Public Health

University of Pittsburgh School of Dental

Medicine

Pittsburgh, Pennsylvania

Lida Radfar, DDS, MS

Diplomat, American Board of Oral Medicine

Clinical Professor of Oral Medicine, Oral

Diagnosis and Radiology Department

University of Oklahoma College of Dentistry

Oklahoma City, Oklahoma

S. Craig Rhodes, DMD, MSD

Associate Professor and Director, Graduate

Endodontics

Center for Advanced Dental Education