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Peter Attia MD - Outlive: The Science and Art of Longevity

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Peter Attia MD Outlive: The Science and Art of Longevity
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    Outlive: The Science and Art of Longevity
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A groundbreaking manifesto on living better and longer that challenges the conventional medical thinking on aging and reveals a new approach to preventing chronic disease and extending long-term health, from a visionary physician and leading longevity expert
One of the most important books youll ever read.Steven D. Levitt, New York Times bestselling author of Freakonomics
Wouldnt you like to live longer? And better? In this operating manual for longevity, Dr. Peter Attia draws on the latest science to deliver innovative nutritional interventions, techniques for optimizing exercise and sleep, and tools for addressing emotional and mental health.
For all its successes, mainstream medicine has failed to make much progress against the diseases of aging that kill most people: heart disease, cancer, Alzheimers disease, and type 2 diabetes. Too often, it intervenes with treatments too late to help, prolonging lifespan at the expense of healthspan, or quality of life. Dr. Attia believes we must replace this outdated framework with a personalized, proactive strategy for longevity, one where we take action now, rather than waiting.
This is not biohacking, its science: a well-founded strategic and tactical approach to extending lifespan while also improving our physical, cognitive, and emotional health. Dr. Attias aim is less to tell you what to do and more to help you learn how to think about long-term health, in order to create the best plan for you as an individual. In Outlive, readers will discover:
Why the cholesterol test at your annual physical doesnt tell you enough about your actual risk of dying from a heart attack.
That you may already suffer from an extremely common yet underdiagnosed liver condition that could be a precursor to the chronic diseases of aging.
Why exercise is the most potent pro-longevity drugand how to begin training for the Centenarian Decathlon.
Why you should forget about diets, and focus instead on nutritional biochemistry, using technology and data to personalize your eating pattern.
Why striving for physical health and longevity, but ignoring emotional health, could be the ultimate curse of all.
Aging and longevity are far more malleable than we think; our fate is not set in stone. With the right roadmap, you can plot a different path for your life, one that lets you outlive your genes to make each decade better than the one before.

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The information and advice presented in this book are not meant to substitute - photo 1
The information and advice presented in this book are not meant to substitute - photo 2

The information and advice presented in this book are not meant to substitute for the advice of your familys physician or other trained healthcare professionals. You are advised to consult with healthcare professionals with regard to all matters pertaining to you and your familys health and well-being.

Copyright 2023 by Peter Attia

All rights reserved.

Published in the United States by Harmony Books, an imprint of Random House, a division of Penguin Random House LLC, New York.

HarmonyBooks.com | RandomHouseBooks.com

Harmony Books is a registered trademark, and the Circle colophon is a trademark of Penguin Random House LLC.

Centenarian Decathlon is a trademark of PA IA, LLC.

Marginal Decade is a trademark of PA IP, LLC.

Library of Congress Cataloging-in-Publication Data has been applied for.

ISBN9780593236598

Ebook ISBN9780593236604

Book design by Andrea Lau

Cover design by Rodrigo Coral Studio

ep_prh_6.0_142982158_c0_r0

AUTHORS NOTE

Writing about science and medicine for the public requires striking a balance between brevity and nuance, rigor and readability. Ive done my best to find the sweet spot on that continuum, getting the substance right while keeping this book accessible to the lay reader. Youll be the judge of whether or not I hit the target.

CONTENTS

_142982158_

INTRODUCTION

In the dream, Im trying to catch the falling eggs.

Im standing on a sidewalk in a big, dirty city that looks a lot like Baltimore, holding a padded basket and looking up. Every few seconds, I spot an egg whizzing down at me from above, and I run to try to catch it in the basket.

Theyre coming at me fast, and Im doing my best to catch them, running all over the place with my basket outstretched like an outfielders glove. But I cant catch them all. Some of themmany of themsmack on the ground, splattering yellow yolk all over my shoes and medical scrubs. Im desperate for this to stop.

Where are the eggs coming from? There must be a guy up there on top of the building, or on a balcony, just casually tossing them over the rail. But I cant see him, and Im so busy I barely even have time to think about him. Im just running around trying to catch as many eggs as possible. And Im failing miserably. Emotion wells up in my body as I realize that no matter how hard I try, Ill never be able to catch all the eggs. I feel overwhelmed, and helpless.

And then I wake up, another chance at precious sleep ruined.

We forget nearly all our dreams, but two decades later, I cant seem to get this one out of my head. It invaded my nights many times when I was a surgical resident at Johns Hopkins Hospital, in training to become a cancer surgeon. It was one of the best periods of my life, even if at times I felt like I was going crazy. It wasnt uncommon for my colleagues and me to work for twenty-four hours straight. I craved sleep. The dream kept ruining it.

The attending surgeons at Hopkins specialized in serious cases like pancreatic cancer, which meant that very often we were the only people standing between the patient and death. Pancreatic cancer grows silently, without symptoms, and by the time it is discovered, it is often quite advanced. Surgery was an option for only about 20 to 30 percent of patients. We were their last hope.

Our weapon of choice was something called the Whipple Procedure, which involved removing the head of the patients pancreas and the upper part of the small intestine, called the duodenum. Its a difficult, dangerous operation, and in the early days it was almost always fatal. Yet still surgeons attempted it; thats how desperate pancreatic cancer is. By the time I was in training, more than 99 percent of patients survived for at least thirty days after this surgery. We had gotten pretty good at catching the eggs.

At that point in my life, I was determined to become the best cancer surgeon that I could possibly be. I had worked really hard to get where I was; most of my high school teachers, and even my parents, had not expected me to make it to college, much less graduate from Stanford Medical School. But more and more, I found myself torn. On the one hand, I loved the complexity of these surgeries, and I felt elated every time we finished a successful procedure. We had removed the tumorwe had caught the egg, or so we thought.

On the other hand, I was beginning to wonder how success was defined. The reality was that nearly all these patients would still die within a few years. The egg would inevitably hit the ground. What were we really accomplishing?

When I finally recognized the futility of this, I grew so frustrated that I quit medicine for an entirely different career. But then a confluence of events occurred that ended up radically changing the way I thought about health and disease. I made my way back into the medical profession with a fresh approach, and new hope.

The reason why goes back to my dream about the falling eggs. In short, it had finally dawned on me that the only way to solve the problem was not to get better at catching the eggs. Instead, we needed to try to stop the guy who was throwing them. We had to figure out how to get to the top of the building, find the guy, and take him out.

Id have relished that job in real life; as a young boxer, I had a pretty mean left hook. But medicine is obviously a bit more complicated. Ultimately, I realized that we needed to approach the situationthe falling eggsin an entirely different way, with a different mindset, and using a different set of tools.

That, very briefly, is what this book is about.

PART I
CHAPTER 1
The Long Game
From Fast Death to Slow Death

There comes a point where we need to stop just pulling people out of the river. We need to go upstream and find out why theyre falling in.

Bishop Desmond Tutu

Ill never forget the first patient whom I ever saw die. It was early in my second year of medical school, and I was spending a Saturday evening volunteering at the hospital, which is something the school encouraged us to do. But we were only supposed to observe, because by that point we knew just enough to be dangerous.

At some point, a woman in her midthirties came into the ER complaining of shortness of breath. She was from East Palo Alto, a pocket of poverty in that very wealthy town. While the nurses snapped a set of EKG leads on her and fitted an oxygen mask over her nose and mouth, I sat by her side, trying to distract her with small talk. Whats your name? Do you have kids?How long have you been feeling this way?

All of a sudden, her face tightened with fear and she began gasping for breath. Then her eyes rolled back and she lost consciousness.

Within seconds, nurses and doctors flooded into the ER bay and began running a code on her, snaking a breathing tube down her airway and injecting her full of potent drugs in a last-ditch effort at resuscitation. Meanwhile, one of the residents began doing chest compressions on her prone body. Every couple of minutes, everyone would step back as the attending physician slapped defibrillation paddles on her chest, and her body would twitch with the immense jolt of electricity. Everything was precisely choreographed; they knew the drill.

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