Peter Matthiessen - Endocrine Disrupters: Hazard Testing and Assessment Methods

Cover photography: Courtesy of Peter Matthiessen and co-authors

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Published simultaneously in Canada

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Library of Congress Cataloging-in-Publication Data:

Endocrine Disrupters: Hazard Testing and Assessment Methods / [edited by] Peter Matthiessen.
p. cm.
Includes index.
ISBN 978-0-470-93209-4 (hardback)
1. Endocrine-disrupting chemicalsToxicity testing. 2. Endocrine-disrupting chemicalsEnvironmental aspects. 3. Endocrine toxicology. I. Matthiessen, Peter.
RA1224.2.E613 2012
615.36dc23

2012015098

PREFACE

The purpose of this book is to describe the state of the art of in vivo ecotoxicological testing methods for endocrine disrupting chemicals. It includes consideration of mammalian methods but addresses in vitro techniques in only a few chapters. The book not only covers methods for all the vertebrate groups as well as several invertebrate phyla but also addresses regulatory issues and possible approaches to hazard assessment and prediction. The book is divided into chapters covering each major taxon as well as the regulatory and hazard assessment topics. Every chapter has been written by acknowledged experts in their respective fields. Furthermore, the main chapters have been subjected to peer review and amended in the light of reviewers comments.

The book does not claim to be exhaustive, although it does provide a helpful route into the subject. This is still a fast-moving field, but the information contained within this volume will be of assistance to scientists involved in testing chemicals for possible endocrine-disrupting properties as well as to regulatory authorities responsible for deciding whether chemicals can be marketed safely. This volume reflects the current (spring 2012) state of knowledge and thus deals largely with those modalities of endocrine disruption that are reasonably well understood and can be broadly categorized as estrogenic, androgenic, thyroidogenic, or steroidogenic (EATS). It must, however, be recognized that environmental chemicals are probably interacting with many other endocrine systems, and as these mechanisms are gradually uncovered, this book will require substantial updating. I nevertheless hope that readers will find this distillation of current knowledge useful and stimulating.

Peter Matthiessen
March 2012

CONTRIBUTORS

Magnus Breitholtz Department of Applied Environmental Science (ITM), Stockholm University, Svante Arrhenius vg 8c, SE-10691 Stockholm, Sweden

Vicki L. Dellarco United States Environmental Protection Agency, 1200 Pennsylvania Avenue, Washington, DC 20460, United States

Tobias Frische Federal Environment Agency (Umweltbundesamt), PO Box 1406, D-06813 Dessau-Rosslau, Germany

John P. Giesy Toxicology Centre and Western College of Veterinary Medicine, University of Saskatchewan, 44 Campus Drive, Saskatoon, SK, S7N 5B3, Canada

Anne Gourmelon Organization for Economic Co-operation and Development, 2 rue Andr-Pascal, F-75775 Paris Cedex 16, France

Louis J. Guillette Jr. Department of Obstetrics and Gynecology, Medical University of South Carolina and Marine Biomedicine and Environmental Sciences, Hollings Marine Laboratory, 96 Jonathan Lucas Street, Charleston, SC 29425, United States

Markus Hecker Toxicology Centre and School of Environment and Sustainability, University of Saskatchewan, 44 Campus Drive, Saskatoon, SK, S7N 5B3, Canada

Thomas H. Hutchinson Centre for Environment, Fisheries and Aquaculture Science, Barrack Road, Weymouth, Dorset DT4 8UB, United Kingdom

Taisen Iguchi Department of Bioenvironmental Research, Okazaki Institute for Integrative Bioscience, National Institute for Basic Biology, 5-1 Higashiyama, Myodaiji, Okazaki Aichi 444-8787, Japan

Flemming Ingerslev Danish Environmental Protection Agency, Strandgade 29, DK-1401, Copenhagen K, Denmark

Paul D. Jones Toxicology Centre and School of Environment and Sustainability, University of Saskatchewan, 44 Campus Drive, Saskatoon, SK, S7N 5B3, Canada

Satomi Kohno Department of Obstetrics and Gynecology, Medical University of South Carolina and Marine Biomedicine and Environmental Sciences, Hollings Marine Laboratory, 96 Jonathan Lucas Street, Charleston, SC 29425, United States

Juliette Legler VU University Amsterdam, Institute for Environmental Studies (IVM), De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands

M. Sue Marty Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Building 1803, Midland, MI 48674, United States

Peter Matthiessen Consultant Ecotoxicologist, Old School House, Brow Edge, Backbarrow, Ulverston, Cumbria LA12 8QX, United Kingdom

Patricia D. McClellan-Green North Carolina State University, Center for Marine Sciences and Technology, 303 College Circle, Morehead City, NC 28557, United States

Jenny Odum Regulatory Science Associates, PO Box 9346, Dunoon, Argyll, PA23 7WR, United Kingdom

Daniel B. Pickford Institute for the Environment, Brunel University, Uxbridge, Middlesex UB8 3PH, United Kingdom

Mike Roberts Department for Environment, Food and Rural Affairs, Nobel House, Smith Square, London SW1P 3JR, United Kingdom

Hans-Christian Stolzenberg Federal Environment Agency (Umweltbundesamt), PO Box 1406, D-06813 Dessau-Rosslau, Germany