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Marie-Louise Newell - Congenital and Perinatal Infections: Prevention, Diagnosis and Treatment

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Congenital and perinatal infections remain a stubborn and major cause of morbidity and mortality in infants throughout the world. This concise, accessible account provides an essential guide to the diagnosis, management, and prevention of these infections. The first three chapters underline how and why infections during this critical period can be so devastating. The main section of the book focuses on individual infections, and emphasizes effective intervention based on the very latest knowledge and techniques. Another unique feature of this account is its recognition that the severity and types of these infections vary considerably from country to country, and from the developing world to the developed world. The international team of experts involved in this compilation have striven to make this an account that will transcend these boundaries and be suitable for all doctors and allied health professionals around the world charged with the care of the mother and newborn.

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title Congenital and Perinatal Infections Prevention Diagnosis and - photo 1
title:Congenital and Perinatal Infections : Prevention, Diagnosis and Treatment
author:McIntyre, James; Newell, Marie-Louise.
publisher:Cambridge University Press
isbn10 | asin:0521789796
print isbn13:9780521789790
ebook isbn13:9780511005855
language:English
subjectFetus--Diseases, Neonatal infections, Infants (Newborn)--Diseases, Fetal Diseases, Neonatal Diseases and Abnormalities, Infant, Newborn, Diseases, Pregnancy Complications, Infectious, Communicable Diseases, Virus Diseases, Infectious Diseases, Infection--
publication date:2000
lcc:RG626.C66 2000eb
ddc:618.32
subject:Fetus--Diseases, Neonatal infections, Infants (Newborn)--Diseases, Fetal Diseases, Neonatal Diseases and Abnormalities, Infant, Newborn, Diseases, Pregnancy Complications, Infectious, Communicable Diseases, Virus Diseases, Infectious Diseases, Infection--

Page i

Congenital and perinatal infections

Perinatal and congenital infections remain a stubborn and major cause of morbidity andmortality in infants throughout the world. This concise, accessible account provides an essentialguide to the diagnosis, management and prevention of these infections. The first three chaptersunderline how and why infections during this critical period can be so devastating. The mainsection of the book focuses on individual infections, with an emphasis on applying the verylatest knowledge and techniques for effective intervention. Another unique feature of thisaccount is its recognition that the severity and types of these infections vary considerably fromcountry to country, and from the developing world to the developed world: the internationalteam of experts involved in this compilation have striven to make this an account that willtranscend these boundaries and be suitable for all doctors and allied health professionals aroundthe world charged with the care of the mother and newborn.


Dr Marie-Louise Newell is Reader in Epidemiology in the Department of Epidemiology andPublic Health at the Institute of Child Health in London. She is coordinator of the EuropeanCollaborative Study on HIV Infections and is well known nationally and internationally for herwork on infections in pregnancy and the consequences for the infant.


Professor James McIntyre is Associate Professor in Obstetrics and Gynaecology at the University of Witwatersrand in South Africa. He is co-director of two research units (Perinatal HIVResearch Unit and the Reproductive Health Research Unit) and is well known as an international authority on HIV and pregnancy.

Page ii

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Page iii

Congenital and perinatal infections

Prevention, diagnosis and treatment

Edited by

Marie-Louise Newell

Institute of Child Health, UCL, London, UK

and

James McIntyre

University of Witwatersrand, South Africa


Page iv PUBLISHED BY CAMBRIDGE UNIVERSITY PRESS VIRTUAL PUBLISHING FOR AND - photo 2

Page iv


PUBLISHED BY CAMBRIDGE UNIVERSITY PRESS (VIRTUAL PUBLISHING) FOR AND ON BEHALF OFTHE PRESS SYNDICATE OF THE UNIVERSITY OF CAMBRIDGE


P U B L I S H E D B Y T H E P R E S S S Y N D I C A T E O F T H E U N I V E R S I T Y O F C A M B R I D G E

The Pitt Building, Trumpington Street, Cambridge, United Kingdom


C A M B R I D G E U N I V E R S I T Y P R E S S

The Edinburgh Building, Cambridge CB2 2RU, UK http://www.cup.cam.ac.uk

40 West 20th Street, New York, NY 100114211, USA http://www.cup.org

10 Stamford Road, Oakleigh, Melbourne 3166, Australia

Ruiz de Alarcn 13, 28014 Madrid, Spain


Cambridge University Press 2000


This edition Cambridge University Press (Virtual Publishing) 2001


This book is in copyright. Subject to statutory exceptionand to the provisions of relevant collective licensing agreements,no reproduction of any part may take place without the written permission of Cambridge University Press.


First published 2000


Printed in the United Kingdom at the University Press, Cambridge


Typeset in Minion 10.5/14pt [V N]


A catalogue record for this book is available from the British Library


ISBN 0 521 78979 6 paperback


Every effort has been made in preparing this book to provide accurate and up-to-date information whichis in accord with accepted standards and practice at the time of publication. Nevertheless, the authors,editors and publisher can make no warranties that the information contained herein is totally free fromerror, not least because clinical standards are constantly changing through research and regulation. Theauthors, editors and publisher therefore disclaim all liability for direct or consequential damages resultingfrom the use of material contained in this book. Readers are strongly advised to pay careful attention toinformation provided by the manufacturer of any drugs or equipment that they plan to use.

The editors would also like to remind readers of the dosage of g for micrograms and that particular careshould always be taken when reading and writing dosage figures.

eISBN 0 511 00585 7 virtual (netLibrary Edition)

Page v

Contents
List of contributorsvii
Prefacexi


Part IGeneral issues

1Infections in pregnancy: introduction3

Catherine S. Peckham


2Pregnancy, immunity and infection15

Cyril J. van Gelderen


3Maternal infections and their consequences32

Patrick S. Ramsey and Robert L. Goldenberg


4Assessing the scientific value of screening for antenatal infections64

Edgardo J. Abalos, A. Metin Glmezoglu and Guillermo Carroli



Part IISpecific infections

5Rubella infection in pregnancy83

Desmond Martin and Barry Schoub


6Perinatal Group B streptococcal infections96

Vibhuti Shah and Arne Ohlsson


7Mother-to-child transmission of cytomegalovirus122

Marie-Louise Newell


8Varicella135

G. Justus Hofmeyr


9Herpes simplex145

Marianne Forsgren and Gunilla Malm

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