Dennis Kasper - Harrisons Infectious Diseases

Derived from Harrisons Principles of Internal Medicine, 19th Edition

Editors

DENNIS L. KASPER, MD

William Ellery Channing Professor of Medicine and Professor of Microbiology and Immunobiology, Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts

ANTHONY S. FAUCI, MD

Chief, Laboratory of Immunoregulation; Director, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

STEPHEN L. HAUSER, MD

Robert A. Fishman Distinguished Professor and Chairman, Department of Neurology, University of California, San Francisco, San Francisco, California

DAN L. LONGO, MD

Professor of Medicine, Harvard Medical School; Senior Physician, Brigham and Womens Hospital; Deputy Editor, New England Journal of Medicine, Boston, Massachusetts

J. LARRY JAMESON, MD, PhD

Robert G. Dunlop Professor of Medicine;

Dean, Perelman School of Medicine at the University of Pennsylvania;

Executive Vice-President, University of Pennsylvania for the Health System, Philadelphia, Pennsylvania

JOSEPH LOSCALZO, MD, PhD

Hersey Professor of the Theory and Practice of Medicine, Harvard Medical School; Chairman, Department of Medicine, and Physician-in-Chief, Brigham and Womens Hospital, Boston, Massachusetts

Copyright 2017 by McGraw-Hill Education. All rights reserved. Except as permitted under the United States Copyright Act of 1976, no part of this publication may be reproduced or distributed in any form or by any means, or stored in a database or retrieval system, without the prior written permission of the publisher.

ISBN: 978-1-25-983598-8
MHID: 1-25-983598-7.

The material in this eBook also appears in the print version of this title: ISBN: 978-1-25-983597-1, MHID: 1-25-983597-9.

eBook conversion by codeMantra
Version 1.0

All trademarks are trademarks of their respective owners. Rather than put a trademark symbol after every occurrence of a trademarked name, we use names in an editorial fashion only, and to the benefit of the trademark owner, with no intention of infringement of the trademark. Where such designations appear in this book, they have been printed with initial caps.

McGraw-Hill Education eBooks are available at special quantity discounts to use as premiums and sales promotions or for use in corporate training programs. To contact a representative, please visit the Contact Us page at www.mhprofessional.com.

Dr. Faucis work as an editor and author was performed outside the scope of his employment as a U.S. government employee. This work represents his personal and professional views and not necessarily those of the U.S. government.

TERMS OF USE

This is a copyrighted work and McGraw-Hill Education and its licensors reserve all rights in and to the work. Use of this work is subject to these terms. Except as permitted under the Copyright Act of 1976 and the right to store and retrieve one copy of the work, you may not decompile, disassemble, reverse engineer, reproduce, modify, create derivative works based upon, transmit, distribute, disseminate, sell, publish or sublicense the work or any part of it without McGraw-Hill Educations prior consent. You may use the work for your own noncommercial and personal use; any other use of the work is strictly prohibited. Your right to use the work may be terminated if you fail to comply with these terms.

THE WORK IS PROVIDED AS IS. McGRAW-HILL EDUCATION AND ITS LICENSORS MAKE NO GUARANTEES OR WARRANTIES AS TO THE ACCURACY, ADEQUACY OR COMPLETENESS OF OR RESULTS TO BE OBTAINED FROM USING THE WORK, INCLUDING ANY INFORMATION THAT CAN BE ACCESSED THROUGH THE WORK VIA HYPERLINK OR OTHERWISE, AND EXPRESSLY DISCLAIM ANY WARRANTY, EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. McGraw-Hill Education and its licensors do not warrant or guarantee that the functions contained in the work will meet your requirements or that its operation will be uninterrupted or error free. Neither McGraw-Hill Education nor its licensors shall be liable to you or anyone else for any inaccuracy, error or omission, regardless of cause, in the work or for any damages resulting therefrom. McGraw-Hill Education has no responsibility for the content of any information accessed through the work. Under no circumstances shall McGraw-Hill Education and/or its licensors be liable for any indirect, incidental, special, punitive, consequential or similar damages that result from the use of or inability to use the work, even if any of them has been advised of the possibility of such damages. This limitation of liability shall apply to any claim or cause whatsoever whether such claim or cause arises in contract, tort or otherwise.

Numbers in brackets refer to the chapter(s) written or cowritten by the contributor.

Neil M. Ampel, MD

Professor of Medicine, University of Arizona; Staff Physician, Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona [112]

Rosa M. Andrade, MD

Department of Medicine, Division of Infectious Diseases, University of California, San Diego, San Diego, California [122]

Cesar A. Arias, MD, PhD, MSc

Associate Professor of Medicine, Microbiology and Molecular Genetics; Director, Laboratory for Antimicrobial Research, University of Texas Medical School at Houston, Houston, Texas; Director, Molecular Genetics and Antimicrobial Unit; Co-Director, International Center for Microbial Genomics, Universidad, El Bosque, Bogota, Colombia [45]

Andrew W. Artenstein, MD

Professor of Medicine, Tufts University School of Medicine, Boston, Massachusetts; Adjunct Professor of Medicine and Health Services, Policy and Practice, Alpert Medical School, Brown University, Providence, Rhode Island; Chair, Department of Medicine, Baystate Health, Springfield, Massachusetts [9]

John C. Atherton, MD, FRCP

Professor of Gastroenterology and Dean of the School of Medicine, University of Nottingham, Nottingham, United Kingdom [60]

Paul S. Auerbach, MD, MS, FACEP, FAWM

Redich Family Professor of Surgery, Division of Emergency Medicine, Stanford University School of Medicine, Stanford, California [136]

Lindsey R. Baden, MD

Associate Professor of Medicine, Harvard Medical School; Dana-Farber Cancer Institute, Brigham and Womens Hospital, Boston, Massachusetts [87]

Natalie J. Badowski, MD

Division of Emergency Medicine, Stanford University School of Medicine, Stanford, California [136]

Alan G. Barbour, MD

Professor of Medicine and Microbiology and Molecular Genetics, University of California Irvine, Irvine, California [81]

Tamar F. Barlam, MD, MSc

Associate Professor of Medicine, Infectious Disease Section, Boston University School of Medicine, Boston, Massachusetts [18, 55]

Rebecca M. Baron, MD

Assistant Professor of Medicine, Harvard Medical School; Associate Physician, Brigham and Womens Hospital, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Boston, Massachusetts [22, 23]

Miriam Baron Barshak, MD

Assistant Professor, Harvard Medical School; Associate Physician, Massachusetts General Hospital, Boston, Massachusetts [22, 23, 29]