Tim D. Spector - Advances in Twin and Sib-pair Analysis

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title	:	Advances in Twin and Sib-pair Analysis
author	:	Snieder, Harold.; MacGregor, Alex J.; Spector, T. D.
publisher	:	Greenwich Medical Media Limited
isbn10 | asin	:	1841100048
print isbn13	:	9781841100043
ebook isbn13	:	9780511042997
language	:	English
subject	Medical genetics--Statistical methods, Twins--Research--Methodology, Brothers and sisters--Research--Methodology, Genetics, Medical--methods, Twin Studies, Twins--genetics, Diseases in Twins--genetics.
publication date	:	2000
lcc	:	RB155.A38 2000eb
ddc	:	616.042
subject	:	Medical genetics--Statistical methods, Twins--Research--Methodology, Brothers and sisters--Research--Methodology, Genetics, Medical--methods, Twin Studies, Twins--genetics, Diseases in Twins--genetics.

Page iii Advances in Twin and Sib-Pair Analysis Edited by Tim D. Spector, Harold Snieder and Alex J. MacGregor all at Twin Research & Genetic Epidemiology Unit St. Thomas' Hospital London, UK

Page iv 2000 Greenwich Medical Media Ltd. 137 Euston Road London NW1 2AA ISBN 1 84110 004 8 First Published 2000 While the advice and information in this book is believed to be true and accurate, neither the authors nor the publisher can accept any legal responsibility or liability for any loss or damage arising from actions or decisions based in this book. The ultimate responsibility for the treatment of patients and the interpretation lies with the medical practitioner. The opinions expressed are those of the authors and the inclusion in this book relating to a particular product, method or technique does not amount to an endorsement of its value or quality, or of the claims made of it by its manufacture. Every effort has been made to check drug dosages; however, it is still possible that errors have occurred. Furthermore, dosage schedules are constantly being revised and new side effects recognised. For these reasons, the medical practitioner is strongly urged to consult the drug companies' printed instructions before administering any of the drugs recommended in this book. Apart from any fair dealing for the purposes of research or private study, or criticism or review, as permitted under the UK Copyright Designs and Patents Act, 1988, this publication may not be reproduced, stored, or transmitted, in any form or by any means, without the prior permission in writing of the publishers, or in the case of reprographic reproduction only in accordance with the terms of the licences issued by the Copyright Licensing Agency in the UK, or in accordance with the terms of the licences issued by the appropriate Reproduction Rights Organization outside the UK. Enquiries concerning reproduction outside the terms stated here should be sent to the publishers at the London address printed above. The right of Dr Tim Spector, Dr Harold Snieder and Dr Alex MacGregor to be identified as editors of this work has been asserted by them in accordance with the Copyright, Designs and Patents Act 1988. The publisher makes no representation, express or implied, with regard to the accuracy of the information contained in this book and cannot accept any legal responsibility or liability for any errors or omissions that may be made. A catalogue record for this book is available from the British Library Distributed worldwide by Oxford University Press Project Manager Gavin Smith Production and Design by Saxon Graphics Limited, Derby Printed in Great Britain

Page v Contents Contributors vii Preface xiii 1. The history of twin and sibling-pair studies Tim D. Spector 1 2. Influence of design on the outcome of twin studies David P. Strachan 11 3. Sample selection and outcome definition in twin studies: experiences from the Finnish twin cohort study Jaakko Kaprio, Pia K. Verkasalo, Markku Koskenvuo 23 4. Practical approaches to account for bias and confounding in twin data Alex J. MacGregor 35 5. The co-twin control study David L. Duffy 53 6. Generalisability and assumptions of twin studies Kirsten Ohm Kyvik 67 7. Fetal programming or genes? David I.W. Phillips 79 8. Twin and sib-pair studies in developing countries Xiping Xu, Changzhong Chen, Tianhua Niu, Binyan Wang, John Rogus, Nicholas J. Schork, Anyun Wang 91 9. Comparison of analysis of variance and likelihood models of twin data analysis Joe C. Christian, Christopher J. Williams 103

Page vi 10. Path analysis of age-related disease traits Harold Snieder 119 11. Survival analysis methods in twin research Andrew Pickles 131 12. Gene-environment interaction and twin studies Nick Martin 143 13. Why `common environmental effects' are so uncommon in the literature John L. Hopper 151

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