David A. Sinclair - Lifespan: Why We Age and Why We Don’t Have To

Praise for LIFESPAN

In this insightful and provocative book that asks questions about how we age, and whether humans can overcome decay and degeneration, Sinclair grapples with some of the most fundamental questions around the science of aging. The result is an elegant and exciting book that deserves to be read broadly and deeply.

Siddhartha Mukherjee, Pulitzer Prizewinning and #1 New York Times bestselling author

If you ever wondered how we age, if we can slow or even reverse aging, and if we can live a healthy 100-plus years, then David Sinclairs new book, Lifespan ... will guide you through the science and the practical strategies to make your health span equal your lifespan, and make your lifespan long and vibrant.

Mark Hyman, MD Director, Cleveland Clinic Center for Functional Medicine and #1 New York Times bestselling author

This is the most visionary book about aging I have ever read. Seize the dayand seize this book!

Dean Ornish, MD, founder & president, Preventive Medicine Research Institute, and New York Times bestselling author of UnDo It!

In Lifespan , David Sinclair eloquently tells us the secret everyone wants to know: how to live longer and age slower. Sinclair convinces us that it is not only possible to live beyond one hundred years, it is inevitable that we will be able to one day do so. If you are someone who wants to know how to beat aging, Lifespan is a must-read.

William W. Li, MD, New York Times bestselling author of Eat to Beat Disease

[I]nsightful, inspiring, and informative. [Sinclair] has translated a wealth of molecular detail into a program that we can all use to live longer and healthier. For anyone interested in understanding the aging process, living longer, and avoiding the diseases of aging, this is the book to read.

Dale Bredesen, MD, New York Times bestselling author of The End of Alzheimers

A visionary book from one of the most masterful longevity scientists of our time. Lifespan empowers us to change our health today while revealing a potential future when we live younger for longer.

Sara Gottfried, MD, New York Times bestselling author of The Hormone Cure

Prepare to have your mind blown. You are holding in your hands the precious results of decades of work, as shared by Dr. David Sinclair, the rock star of aging and human longevity.

Dave Asprey, founder and CEO of Bulletproof and New York Times bestselling author of The Bulletproof Diet

Imagine a world in which we can live long enough to meet not just our grandchildren, but our great-grandchildren. This is Sinclairs vision for the future of humankind, a vision that looks to science, nature, history, and even politics to make the case that it is possible to live well into our hundreds. Lifespan is boldly leading the way.

Jason Fung, MD, author of The Diabetes Code and The Obesity Code

In Lifespan , Dr. David Sinclair... provides us with the everyday tools that we can all use to stop what he now calls the disease of aging.... You owe it to yourself and your loved ones to read and follow his advice, as I have for the last 15 years!

Steven R. Gundry, MD, New York Times bestselling author of The Longevity Paradox and medical director of the International Heart and Lung Institute

Lifespan ... transcends everything we know about aging and longevitya combination of brilliant scientific work, a pioneering mind, and the dream for a longer, healthier and happier life. Lifespan provides a vision for our future and the road map on how to get there, merging scientific breakthroughs and simple lifestyle changes to not only help us feel younger, but actually become younger.

Naomi Whittel, New York Times bestselling author of Glow15

David Sinclair masterfully presents a bold vision of the future in which humanity is able to slow or reverse the aging process and live younger, healthier lives for longer.

Victor J. Dzau, MD, president of the US National Academy of Medicine and CEO of Duke University Medical Center

There are few books that have ever made me think about science in a fundamentally new way. David Sinclairs book did that for me on aging. This is a book that anyone who ages must read.

Leroy Hood, PhD, professor at the California Institute of Technology, inventor, entrepreneur, member of all three US National Academies, and coauthor of Code of Codes

In Lifespan , the full force of [Sinclairs] optimism, humor, and soft-spoken eloquence as a storyteller-scientist come through. Im hoping we have David Sinclair with us and doing his science and writing books for another 500 years, give or take a century.

David Ewing Duncan, award-winning journalist, bestselling author, and curator of Arc Fusion

Lifespan gives us hope for an extraordinary life. As the brilliant Dr. David Sinclair explains, aging is a disease, and that disease is treatable. This eye-opening book takes you to front lines of incredible breakthroughs. Enjoy this must-read masterpiece!

Peter H. Diamandis, MD, New York Times bestselling author of Abundance and Bold

[D]escribes real science that will question the foundation of everything we assume about our life and society.

Salman Khan, founder of Khan Academy

David is a pioneer poised to change how we think about and understand aging.

Stephanie Lederman, CEO of the American Federation for Aging Research (AFAR), New York

The most important message and priority of our time. For years to come, humanity will reflect on this book with awe and respect. Read it.... Your life depends on it.

Marc Hodosh, former owner & cocreator of TEDMED

A tour de force. Sinclairs book, and his lifes work, ranks with humanitys greatest contributions to helping enhance the joy and happiness of life, ranking with the works of Jenner, Pasteur, Salk, Locke, Gandhi, and Edison. A masterpiece.

Martine Rothblatt, founder, Chairwoman of the Board, and CEO of United Therapeutics and creator of SiriusXM Satellite Radio

Stepping on the moon changed humanity. In Lifespan , Sinclair takes the ultimate step for humanity that will transform our lives beyond anything we could ever have imagined. The author is bold, the science is profound, and our future is here.

Henry Markram, PhD, professor at EPFL, Switzerland, director of the Blue Brain Project, and founder of Frontiers open-access journals

An intellectually fascinating book with tantalizing insights on the most important issue about yours and everyones future.

Andrew Scott, PhD, professor of economics at the London Business School and author of The 100-Year Life

This publication contains the opinions and ideas of its author. It is sold with the understanding that the author and publisher are not engaged in rendering health services in the book. The reader should consult his or her own medical and health providers as appropriate before adopting any of the suggestions in this book or drawing inferences from it.

The author and publisher specifically disclaim all responsibility for any liability, loss, or risk, personal or otherwise, which is incurred as a consequence, directly or indirectly, of the use and application of any of the contents of this book.

An Imprint of Simon & Schuster, Inc.

1230 Avenue of the Americas

New York, NY 10020

www.SimonandSchuster.com

Copyright 2019 by David A. Sinclair, PhD

All rights reserved, including the right to reproduce this book or portions thereof in any form whatsoever. For information, address Atria Books Subsidiary Rights Department, 1230 Avenue of the Americas, New York, NY 10020.