Richard A. Smith - Neurotherapeutics in the Era of Translational Medicine

Academic Press is an imprint of Elsevier

125 London Wall, London EC2Y 5AS, United Kingdom

525 B Street, Suite 1650, San Diego, CA 92101, United States

50 Hampshire Street, 5th Floor, Cambridge, MA 02139, United States

The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, United Kingdom

2021 Elsevier Inc. All rights reserved.

No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publishers permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions.

This book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein).

Notices

Knowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.

Practitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.

To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.

Library of Congress Cataloging-in-Publication Data

A catalog record for this book is available from the Library of Congress

British Library Cataloguing-in-Publication Data

A catalogue record for this book is available from the British Library

ISBN 978-0-12-816475-4

For information on all Academic Press publications visit our website at https://www.elsevier.com/books-and-journals

Publisher: Nikki Levy

Acquisitions Editor: Melanie Tucker

Editorial Project Manager: Kristi Anderson

Production Project Manager: Punithavathy Govindaradjane

Cover Designer: Matthew Limbert

Typeset by SPi Global, India

Karen Aboody Department of Developmental and Stem Cell Biology, Beckman Research Institute of City of Hope, Duarte, CA, United States

Olubankole Aladesuyi Arogundade Department of Neurosciences, University of California at San Diego, La Jolla, CA, United States

Giovanni Appendino Department of Pharmaceutical Sciences, University of Eastern Piedmont, Novara, Italy

Weiqi Bao PET Center, Huashan Hospital, Fudan University, Shanghai, China

Marco A.S. Baptista The Michael J. Fox Foundation for Parkinson's Research, New York, NY, United States

Danielle Beaulieu Origent Data Sciences, Inc., Vienna, VA, United States

Frank Bennett Ionis Pharmaceuticals, Carlsbad, CA, United States

Emma Brand Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, McCance Center for Brain Health, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States

Don Cleveland Ludwig Institute at the University of California, San Diego, La Jolla, CA, United States

Stanley L. Cohan Providence Multiple Sclerosis Center, Providence Brain and Spine Institute, Portland, OR, United States

Jonavelle Cuerdo Origent Data Sciences, Inc., Vienna, VA, United States

Jim DeMesa Emerald Health Pharmaceuticals, San Diego, CA, United States

David L. Ennist Origent Data Sciences, Inc., Vienna, VA, United States

Meryem Guler Cogent Family Healthcare, Mountain View, CA, United States

Nada Hindiyeh Department of Neurology, Stanford University, Stanford, CA, United States

Hanna Hovren Center for Neurologic Study, La Jolla, CA, United States

Yiyun Henry Huang PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, United States

Hongmei Jia Ministry of Education Key Laboratory of Radiopharmaceuticals, College of Chemistry, Beijing Normal University, Beijing, China

Jie Jiang Department of Cell Biology, Emory University, Atlanta, GA, United States

Brian K. Kaspar Milo Biotechnology, San Diego, CA, United States

Petra Kaufmann VC R&D Translational Medicine R&D, AveXis, A Novartis Company, San Diego, CA, United States

Randall Kaye Center for Neurologic Study, La Jolla, CA, United States

Jeffery W. Kelly

Department of Chemistry

The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA, United States

Mike Keymer Origent Data Sciences, Inc., Vienna, VA, United States

Doo Yeon Kim Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, McCance Center for Brain Health, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States

Kiren Kresa-Reahl Atara Biotherapeutics Inc., Thousand Oaks, CA, United States

Ikjae Lee Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, United States

Melanie Leitner Accelerating NeuroVentures, LLC, Boston, MA, United States

Stefanie N. Linch Cancer Early Detection Advanced Research Center (CEDAR), Knight Cancer Institute, Oregon Health and Science University, Portland, OR, United States

Elisabeth B. Lucassen Providence Multiple Sclerosis Center, Providence Brain and Spine Institute, Portland, OR, United States

Timothy Miller Department of Neurology, Washington University in St. Louis-School of Medicine, St. Louis, MO, United States

Rachael Mooney Department of Developmental and Stem Cell Biology, Beckman Research Institute of City of Hope, Duarte, CA, United States

Gaetano Morello Emerald Health Naturals, Vancouver, BC, Canada

Eduardo Muoz

Emerald Health Pharmaceuticals, San Diego, CA, United States

Maimonides Biomedical Research Institute of Crdoba (IMIBIC)

Department of Cellular Biology, Physiology and Immunology, University of Crdoba

University Hospital Reina Sofa, Crdoba, Spain

Michael Murray Emerald Health Naturals, Vancouver, BC, Canada

Hoi Wa Ngai Department of Developmental and Stem Cell Biology, Beckman Research Institute of City of Hope, Duarte, CA, United States

Joseph Park Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, McCance Center for Brain Health, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States

Dustin Pierce Origent Data Sciences, Inc., Vienna, VA, United States

Jana Portnow Department of PS Medical Oncology, Beckman Research Institute of City of Hope, Duarte, CA, United States

Evan T. Powers Department of Chemistry, The Scripps Research Institute, La Jolla, CA, United States

Luisa Quinti Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, McCance Center for Brain Health, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, United States