Dmytro Klokol - Immunotherapy in Bioregenerative Medicine

IMMUNOTHERAPY IN BIOREGENERATIVE MEDICINE

Published by
EUROPEAN WELLNESS ACADEMY

Copyright 2022 by Dato Sri Mike K.S. Chan,
Dmytro Klokol, MD, PhD, Roni Moya, BMD

All rights reserved. Neither this book, nor any parts within it may be sold or reproduced in any form or by any electronic or mechanical means, including information storage and retrieval systems, without permission in writing from the author. The only exception is by a reviewer, who may quote short excerpts in a review.

Library of Congress Control Number: 2022941476

ISBN (paperback): 9781662930140
eISBN: 9781662930157

DEDICATIONS

Dato Sri Mike Chan dedicates this book to
Dr. Milan Persic, Dr. Samuel Baxas,
Prof. Dr. Albert Landsberger,
Dr. Michael Culbert and Dr. Wolfram Kuhnau.

Dr. Roni Moya dedicates this book to
his beloved mother and
the masters he met along the professional journey.

Dr. Dmytro Klokol dedicates this book to
the Heroes-defenders of Ukraines sovereignty.
!

CONTENTS

In the One Health era the book Immunotherapy in bioregenerative medicine represents an obligatory reading topic, mostly for physicians and the other health professionals which would improve the way they practice medicine and related topics. It is important to have a more holistic view to treat patients to make them recover from disease or to keep them healthy.

Immunotherapy is a type of treatment that helps our immune system to maintain our physiology and homeostasis and to fight against infectious or neoplastic diseases using immunobiologicals.

The seriousness of immunobiological production to human use as immunotherapy in humans follows strict rules and laws making them expensive and inaccessible when we think of public health services. However, the cost of manufacturing immunobiological needs to be improved as science development and innovation are getting better in the majority of countries.

Bioregenerative medicine using immunotherapy represents a new field of medical practice that need to be accepted by the scientific community and public health systems to be applied to all population. Immunotherapy has not been used widely, only in a few medical situations such as neoplasia and autoimmunity. Herein the authors highlight the use of these immunobiological products in anti-aging medicine. However more immunobiological industries must be developed to deliver low-cost immunotherapy to people who most need it.

The aging process is natural in human and non-human beings. However, nowadays we are exposed by breathing, eating, and living to many inflammatory conditions, which cause acceleration of the aging process. Junk air, food, and lifestyle are sold as healthy and many people are affected by the inflammation they cause. In this book, the authors elegantly show that with the right food intake we can avoid disease and keep young. The authors go into depth in the new knowledge of nutrition and anti-aging that will catch the readers attention. With misinformation and fake news, it is important to have scientific material like this book that targets health professionals with a holistic point of view of human health.

This book addresses, in an unprecedented way, several complex concepts didactically explaining how regenerative medicine can be achieved using the news of immunotherapy and immunology. Immunobiologicals are there to be used to recover the activity of immune cells in their best functionality to fight against pathogens and cancer, as well as, to maintain organism homeostasis.

The authors discuss highly in-depth topics between chapters showing how basic research turned into benefits from acute to chronic diseases, as well as to keep us young and healthy. The book represents a new way to think about immunotherapy as anti-aging and bioregenerative medicine.

Paula Ordonhez Rigato
Head of Immunobiology and Biomarkers Laboratory, Center of Immunology, Institute Adolfo Lutz (Laboratory of Public Health), So Paulo, Brazil
Biomedical Professional (University of Mogi das Cruzes, Sao Paulo, Brazil);
Specialist in Clinical Pathology (University Federal of So Paulo State - UNIFESP);
Specialist in Immunodeficiency (School of Medicine University of So Paulo);
Master and PhD in Immunology (Institute of Biomedical Sciences of University of So Paulo); PosDoc in Immunology and Vaccinology by UNIFESP, CEA-Fontanay-Aux-Roses-France and University of Sao Paulo), Scientific Researcher in Institute Adolfo Lutz.

The world is aging! Each year life expectancy increases in many countries. The age pyramid lost the thin peak represented by elderly, and its wide base of newborns, transforming itself in almost an upside-down pyramid.

With the accumulation of aged people, also comes a health service overload, so the understood of changes in an organism related with increasing of age are really an essential discussion.

This book brings this topic with details. A dense and complex text, passing through every main mechanism of an organism age-related changes. Each chapter discuss carefully the complex and, at the same time, dynamic alterations that come with senescence.

Each one of these alterations are also described by the mechanisms involved, and the impact of the change. These changes can affect immune defense, vaccine responses, organ functioning, and even simple aspects as digestion and nutrients absorption.

Besides that, the topics of immunotherapy, which is little explored on age research area, represents on the book an interesting discussion about applications and some problems. But nowadays think about alternatives to underwent elderly problems by using immune mediated treatment are the real future to get around the health overload problem that is being occasioned by world aging.

Knowing this kind of information makes us, as humans start to think about our lifestyle and habits, and possible modifications to improve quality of life. And as researchers, the content of the book is important to impulse more discovers, researches and data about interventions and treatments to reduce some side effect of this biological process called Aging.

Juliana Ruiz Fernandes,
biologist (Centro Universitrio So Camilo, So Paulo, Brazil);
Master and PhD in Sciences (Faculdade de Medicina da Universidade de So Paulo);
Currently PosDoc in Immunossenescence by Faculdade
de Medicina da Universidade de So Paulo.

Aging is one of the most complex processes in human development and is associated with chronic diseases such as diabetes, cardiovascular dysfunction, neurodegeneration and cancer predisposition. It is possible that one of the fundamental causes of these diseases is aging itself. The hallmarks of aging include stem cell exhaustion, altered intercellular communication, genomic instability and telomere attrition, epigenetic alterations, loss of protein homeostasis (proteostasis), altered nutrient and growth factor sensing, mitochondrial dysfunction and cellular senescence []. Essentially, inflammaging is the process of the immune systems aging.