Lisa H. Butterfield - Cancer Immunotherapy Principles and Practice

i ii Cancer Immunotherapy Principles and Practice

iii Cancer Immunotherapy Principles and Practice

Editors

Lisa H. Butterfield, PhD

Professor of Medicine, Surgery, and Immunology

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania

Howard L. Kaufman, MD, FACS

Associate Director of Clinical Sciences

Chief Surgical Officer

Rutgers Cancer Institute of New Jersey

Professor and Chief

Division of Surgical Oncology

Rutgers Robert Wood Johnson Medical School

New Brunswick, New Jersey

Francesco M. Marincola, MD, FACS

Distinguished Scientist

AbbVie Corporation

Redwood City, California

Section Editors

Thomas F. Gajewski, MD, PhD

Paolo A. Ascierto, MD

Raj K. Puri, MD, PhD

Visit our website at www.demosmedical.com

ISBN: 9781620700976

ebook ISBN: 9781617052736

Acquisitions Editor: David DAddona

Compositor: Newgen KnowledgeWorks

Copyright 2017 Society for Immunotherapy of Cancer

Published by Demos Medical Publishing, an imprint of Springer Publishing Company, LLC

All rights reserved. This book is protected by copyright. No part of it may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of SITC.

Medicine is an ever-changing science. Research and clinical experience are continually expanding our knowledge, in particular our understanding of proper treatment and drug therapy. The authors, editors, and publisher have made every effort to ensure that all information in this book is in accordance with the state of knowledge at the time of production of the book. Nevertheless, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the contents of the publication. Every reader should examine carefully the package inserts accompanying each drug and should carefully check whether the dosage schedules mentioned therein or the contraindications stated by the manufacturer differ from the statements made in this book. Such examination is particularly important with drugs that are either rarely used or have been newly released on the market.

Library of Congress Cataloging-in-Publication Data

Names: Butterfield, Lisa H., editor. | Kaufman, Howard L., editor. | Marincola, Francesco M., editor.

Title: Cancer immunotherapy principles and practice / [edited by] Lisa H. Butterfield, Howard L. Kaufman, Francesco M. Marincola.

Other titles: Cancer immunotherapy (Butterfield)

Description: New York : Demos Medical Publishing, [2017] | Includes bibliographical references and index.

Identifiers: LCCN 2017014005| ISBN 9781620700976 (hardback) | ISBN 9781617052736 (ebook)

Subjects: | MESH: Neoplasmstherapy | Immunotherapymethods | Neoplasmsimmunology

Classification: LCC RC271.I45 | NLM QZ 266 | DDC 616.99/406dc23

LC record available at https://lccn.loc.gov/2017014005

Printed in the United States of America by Strategic Content Imaging.

17 18 19 20 21 / 5 4 3 2 1

v vi Past SITC Presidents

Robert K. Oldham, MD

Ernest C. Borden, MD

Richard V. Smalley, MD

Michael J. Mastrangelo, MD

Michael J. Hawkins, MD

Ronald B. Herberman, MD

David R. Parkinson, MD

Michael T. Lotze, MD

Robert O. Dillman, MD, FACP

Michael B. Atkins, MD

Ulrich Keilholz, MD

Jon M. Wigginton, MD

Bernard A. Fox, PhD

Thomas F. Gajewski, MD, PhD

Richard V. Smalley, MD Memorial Lectureship Award Recipients

Suzanne L. Topalian, MD

Tasuku Honjo, MD, PhD

Giorgio Trinchieri, MD

Carl H. June, MD

Theresa L. Whiteside, PhD

Ralph M. Steinman, MD

James P. Allison, PhD

Isaiah J. Fidler, DVM, PhD

Giorgio Parmiani, MD

Ernest Borden, MD

Ronald Levy, MD

Steven A. Rosenberg, MD, PhD

vii Contents

William Kelly, Michael T. Lotze, and Michael B. Atkins

Francesco M. Marincola

Francesco M. Marincola and Michael T. Lotze

Orian Bricard, Nicolas van Baren, and Pierre G. Coulie

Lei Cai, Theodoros Michelakos, Teppei Yamada, Song Fan, Joseph H. Schwab, Cristina R. Ferrone, and Soldano Ferrone

David Furman

Abul K. Abbas and Lucy S. K. Walker

Lucy S. K. Walker and Abul K. Abbas

Yu Zhang, Bonnie Blomberg, and Joseph D. Rosenblatt

Julie Y. Djeu and Melba Marie Tejera

Alberto Mantovani and Isabella Barajon

Andrea De Maria, Lorenzo Moretta, Gabriella Pietra, and Massimo Vitale

Ernesto Perez-Chanona and Giorgio Trinchieri

Genyuan Zhu, Michelle M. Appenheimer, James J. Mul, and Sharon S. Evans

David H. Munn and Vincenzo Bronte

Thomas F. Gajewski

Thomas F. Gajewski

Thomas F. Gajewski

Rachel Perret, Alena Donda, and Pedro Romero

Emanuela Romano and Kim Margolin

Shivani Srivastava, Alexander I. Salter, and Stanley R. Riddell

Randy F. Sweis and Jason J. Luke

Rebekka Duhen and Andrew D. Weinberg

Sandra Demaria and Lorenzo Galluzzi

Larissa Pikor, John C. Bell, and Howard L. Kaufman

Morganna Freeman, Raphael Moreira, Omid Hamid, and Patrick A. Ott

Lisa H. Butterfield

Lisa H. Butterfield

Dmitriy W. Gutkin and Michael R. Shurin

Davide Bedognetti, Zohreh Tatari-Calderone, Francesco M. Marincola, and Ena Wang

Paul F. Robbins and Stefani Spranger

Robert Saddawi-Konefka and Jack D. Bui

Priyanka B. Subrahmanyam, Lisa H. Butterfield, Peter P. Lee, and Holden T. Maecker

Ilona Kryczek, Timothy Frankel, and Weiping Zou

Raju R. Raval and William E. Carson III

Theresa L. Whiteside

Maartje C. A. Wouters and Brad H. Nelson

Damien Chaussabel

Greg M. Delgoffe

Graham Pawelec

Max M. Wattenberg and Lawrence Fong

Paolo A. Ascierto

Paolo A. Ascierto

Antonio M. Grimaldi, Michael Postow, and Paolo A. Ascierto

Jrgen C. Becker and Selma Ugurel

Moshe C. Ornstein and Brian I. Rini

Mihir M. Shah and Usha Malhotra

Delia DAvola, Ignacio Melero, and Bruno Sangro

Kunle Odunsi, Maria Agarwal, Thinle Chodon, and Cornelia L. Trimble

Leisha A. Emens and Rita Nanda

Maria A. Velez, Yi-Long Wu, Steven M. Dubinett, Zhong-Yi Dong, Si-Pei Wu, and Edward B. Garon