Gerald S. Falchook (editor) - Handbook of targeted cancer therapy and immunotherapy

Acquisitions Editor: Ryan Shaw Editorial Coordinator: Jeremiah Kiely Marketing Manager: Rachel Mante-Leung Production Project Manager: David Saltzberg Design Coordinator: Steve Druding Manufacturing Coordinator: Beth Welsh Prepress Vendor: S4 Carlisle Publishing Services Second edition Copyright 2019 Wolters Kluwer. Copyright 2015 Wolters Kluwer Health. All rights reserved. This book is protected by copyright. No part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. government employees are not covered by the above-mentioned copyright. government employees are not covered by the above-mentioned copyright.

To request permission, please contact Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at (products and services). 9 8 7 6 5 4 3 2 1 Printed in China (or the United States of America) Library of Congress Cataloging-in-Publication Data Names: Karp, Daniel D., editor. | Falchook, Gerald S., editor. Title: Handbook of targeted cancer therapy / editors, Daniel D. Karp, Gerald S. Falchook.

Other titles: Targeted cancer therapy Description: 2nd edition. | Philadelphia : Wolters Kluwer, [2018] | Includes bibliographical references and index. Identifiers: LCCN 2018012516 | eISBN 9781496389145 Subjects: | MESH: Neoplasmsdrug therapy | Molecular Targeted Therapymethods | Antineoplastic Agentsadministration & dosage | Antineoplastic Agentsmetabolism | Antineoplastic Agents, Immunological | Handbooks Classification: LCC RC271.C5 | NLM QZ 39 | DDC 616.99/4061dc23 LC record available at https://lccn.loc.gov/2018012516 This work is provided as is, and the publisher disclaims any and all warranties, express or implied, including any warranties as to accuracy, comprehensiveness, or currency of the content of this work. This work is no substitute for individual patient assessment based upon healthcare professionals examination of each patient and consideration of, among other things, age, weight, gender, current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is merely a reference tool. Healthcare professionals, and not the publisher, are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and treatments.

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Johnique T. Atkins, PhD The University of Texas MD Anderson Cancer Center Kavitha Balaji, PhD The University of Texas MD Anderson Cancer Center Sarah Baldwin, RN, ANP-BC The University of Texas MD Anderson Cancer Center Fedricker D. Barber, PhD, RN, ANP-BC, AOCNP The University of Texas MD Anderson Cancer Center Tamara G.

Barnes, RN, MSN, CNS, AOCNS The University of Texas MD Anderson Cancer Center Laura Beatty, PA-C The University of Texas MD Anderson Cancer Center Jenny R. Berry, BSN, MSN The University of Texas MD Anderson Cancer Center Prajwal C. Boddu, MD The University of Texas MD Anderson Cancer Center Mustafa Bozkurt, MD The University of Texas MD Anderson Cancer Center Lindsay G. Bramwell, MSN, RN, ACNS-BC Sarah Cannon Research Institute at HealthONE Manojkumar Bupathi, MD, MS Rocky Mountain Cancer Centers Lauren Byers, MD The University of Texas MD Anderson Cancer Center Maria E. Cabanillas, MD The University of Texas MD Anderson Cancer Center Anthony Conley, MD The University of Texas MD Anderson Cancer Center Paul G. Corn, MD, PhD The University of Texas MD Anderson Cancer Center Senthil Damodaran, MD, PhD The University of Texas MD Anderson Cancer Center Gerald S.

Falchook, MD, MS Sarah Cannon Research Institute at HealthONE Renata Ferrarotto, MD The University of Texas MD Anderson Cancer Center Siqing Fu, MD, PhD The University of Texas MD Anderson Cancer Center Goldy C. George, PhD The University of Texas MD Anderson Cancer Center Sangeeta Goswami, MD, PhD The University of Texas MD Anderson Cancer Center Roman Groisberg, MD The University of Texas MD Anderson Cancer Center Mouhammed A. Habra, MD The University of Texas MD Anderson Cancer Center Jennifer Herold, PhD The University of Texas MD Anderson Cancer Center Laura L. Holman, MD University of Oklahoma Health Sciences Center David S. Hong, MD The University of Texas MD Anderson Cancer Center Le Huang, PhD The University of Texas MD Anderson Cancer Center Ecaterina Ileana-Dumbrava, MD, MS The University of Texas MD Anderson Cancer Center Tiffiny L. Jackson, RN, MS, FNP-BC The University of Texas MD Anderson Cancer Center Filip Janku, MD, PhD The University of Texas MD Anderson Cancer Center Milind Javle, MD The University of Texas MD Anderson Cancer Center Tapan M.

Kadia, MD The University of Texas MD Anderson Cancer Center Radhika Kainthla, MD The University of Texas Southwestern Medical Center Daniel D. Karp, MD The University of Texas MD Anderson Cancer Center Ahmed O. Kaseb, MD The University of Texas MD Anderson Cancer Center Ed Kheder, MD The University of Texas MD Anderson Cancer Center Holly Kinahan, RN, ANP-C, OCN The University of Texas MD Anderson Cancer Center E. Scott Kopetz, MD, PhD The University of Texas MD Anderson Cancer Center Hans C. Lee, MD The University of Texas MD Anderson Cancer Center JoAnn D. Lim, PharmD, BCOP The University of Texas MD Anderson Cancer Center Xiaochun Liu, MD, PhD Baxter Healthcare Corporation Kathrina Marcelo-Lewis, PhD The University of Texas MD Anderson Cancer Center Erminia Massarelli, MD, PhD, MS City of Hope Hossein Maymani, MD The University of Texas MD Anderson Cancer Center Meredith A.

McKean, MD The University of Texas MD Anderson Cancer Center Victoria A. Miller, FNP-BC The University of Texas MD Anderson Cancer Center Sandra Montez, RN The University of Texas MD Anderson Cancer Center Yong H. Moon, MD The University of Texas MD Anderson Cancer Center Shhyam Moorthy, PhD The University of Texas MD Anderson Cancer Center Mariela B. Murphy, MD The University of Texas MD Anderson Cancer Center Aung Naing, MD The University of Texas MD Anderson Cancer Center Robert Orlowski, MD The University of Texas MD Anderson Cancer Center Lance C. Pagliaro, MD Mayo Clinic Shubham Pant, MD The University of Texas MD Anderson Cancer Center Amy B. L. L.

Pereira, MD, PhD The University of Texas MD Anderson Cancer Center Ashley Perkins, MS The University of Texas MD Anderson Cancer Center Sarina A. Piha-Paul, MD, MS The University of Texas MD Anderson Cancer Center Patrick Pilie, MD The University of Texas MD Anderson Cancer Center Matthew Reilley, MD University of Virginia Jordi Rodon-Ahnert, MD, PhD The University of Texas MD Anderson Cancer Center Jason Roszik, MBA, PhD The University of Texas MD Anderson Cancer Center Shiraj Sen, MD, PhD The University of Texas MD Anderson Cancer Center Jatin J. Shah, MD Karyopharm Therapeutics Arlene O. Siefker-Radtke, MD The University of Texas MD Anderson Cancer Center Raphael Steiner, MD The University of Texas MD Anderson Cancer Center Ana Stuckett, PhD The University of Texas MD Anderson Cancer Center Vivek Subbiah, MD The University of Texas MD Anderson Cancer Center Nizar M. Tannir, MD The University of Texas MD Anderson Cancer Center Hussein Tawbi, MD, PhD The University of Texas MD Anderson Cancer Center Debu Tripathy, MD The University of Texas MD Anderson Cancer Center Jason R. Westin, MD The University of Texas MD Anderson Cancer Center Shannon N.

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