Herbert B. Newton (editor) - Neurological Complications of Systemic Cancer and Antineoplastic Therapy

Second Edition

Herbert B. Newton, MD, FAAN

Director, Neuro-Oncology Center, Orlando, FL, United States

Medical Director, CNS Oncology Program, Advent Health Cancer Institute, Advent Health Orlando Campus & Advent Health Medical Group, Orlando, FL, United States

Professor of Neurology, UCF School of Medicine, Orlando, FL, United States

Professor of Neurology & Neurosurgery (Retired), Division of Neuro-Oncology, Esther Dardinger Endowed Chair in Neuro-Oncology, James Cancer Hospital & Solove Research Institute, Wexner Medical Center at the Ohio State University, Columbus, OH, United States

Mark G. Malkin, MD, FRCPC, FAAN

Director of the Neuro-Oncology Program at Massey Cancer Center, Virginia Commonwealth University School of Medicine, Richmond, VA, United States

Director of the Neuro-Oncology Division, Department of Neurology, Virginia Commonwealth University School of Medicine, Richmond, VA, United States

Professor of Neurology and Neurosurgery, William G. Reynolds, Jr. Chair in Neuro-Oncology, Virginia Commonwealth University School of Medicine, Richmond, VA, United States

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Cover images:

Background image: Colorectal metastasis, from Virginia Commonwealth University Department of Pathology and Hope T. Richard.

Four inset images: From left to right: Chapter 2 Figures 16A, 3C, 50A, and 41A, from Richard D. Beegle, MD on behalf of AdventHealth.

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ISBN: 978-0-12-821976-8

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I would like to thank my wife, Cindy, and all of the children in my wonderful mixed familyAlex and Ashley Newton, and Sammi, Skylar, and Cameron Burrell, for their love, patience, and support while I worked on this book project.

I would also like to thank my Neuro-Oncology patients and their families for their amazing courage and strength in the face of adversity, which has been a constant inspiration.

Herbert B. Newton

To my peers and support staff for their confidence in me.

To my patients and their families for their trust in me.

To the memory of my parents, Drs. Dina Gordon Malkin and Aaron Malkin, who instilled in me a love of learning and respect for othersparticularly those less fortunate.

To my son Adam whose intellectual curiosity knows no bounds.

And to my wife, Joy, whose unconditional love and support sustains me.

Mark G. Malkin

Manmeet S. Ahluwalia Miami Cancer Institute, Baptist Health South Florida, Miami, FL, United States

Yesne Alici Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, NY, United States

Deborah Allen Nursing Research, Duke University, Durham, NC, United States

Brian M. Andersen Center for Neuro-Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, United States

Joachim M. Baehring Departments of Neurology and Neurosurgery, Yale University School of Medicine, New Haven, CT, United States

Onyinye Balogun Department of Radiation Oncology, Weill Cornell Medicine and New York Presbyterian Hospital, New York, NY, United States

Taylor Beal Southern Methodist University, Dallas, TX, United States

Richard Douglas Beegle Department of Neuroradiology, AdventHealth Medical Group Central Florida Division, Orlando, FL, United States

Ankush Bhatia Department of Neurology, The University of Houston Health Science Center at Houston, McGovern Medical School, Houston, TX, United States

Rachel Boutte Department of Psychology, Virginia Commonwealth University, Richmond, VA, United States

Priscilla K. Brastianos Divisions of Neuro-Oncology and Medical Oncology, Departments of Medicine and Neurology, Massachusetts General Hospital, Boston, MA, United States

Julia Brechbeil Department of Psychology, Virginia Commonwealth University, Richmond, VA, United States

William S. Breitbart

Department of Psychiatry, Weill Medical College of Cornell University

Department of Psychiatry and Behavioral Sciences, Memorial Sloan-Kettering Cancer Center

Department of Medicine, Pain and Palliative Care Service, Memorial Sloan-Kettering Cancer Center, New York, NY, United States

Toni Cao Department of Neurology, Northwestern University, Chicago, IL, United States

Alan Carver Department of Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, United States

Marc C. Chamberlain Department of Neurology and Neurological Surgery, University of Washington, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, Seattle, WA, United States

Samuel T. Chao Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, United States

Eloise Chapman-Davis Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Weill Cornell Medicine and New York Presbyterian Hospital, New York, NY, United States