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Nabil F. Saba - Esophageal Cancer: Prevention, Diagnosis and Therapy

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Nabil F. Saba Esophageal Cancer: Prevention, Diagnosis and Therapy

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The second edition of this very successful book documents the latest progress in the prevention, diagnosis and treatment of esophageal cancer and includes additional sections covering novel targeted therapeutic approaches, immunotherapy and palliative and nutritional support for patients. Furthermore, the sections covering epidemiology, molecular biology, pathology, staging and radiologic and endoscopic assessments have been thoroughly updated and expanded. The principles of surgical resection, radiation therapy and systemic therapy are reviewed and attention is paid to the multidisciplinary approaches to the management of early stage cervical, thoracic, distal and junctional tumors. Updated information is also provided on the treatment of metastatic and recurrent disease as well as approaches that may impact future care, such as chemoprevention. Esophageal Cancer: Prevention, Diagnosis and Therapy will assist specialists from various disciplines, including surgery, radiation therapy, gastroenterology, medical oncology and palliative medicine, in delivering optimal, up-to-date care to the benefit of patients.

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Editors Nabil F Saba and Bassel F El-Rayes Esophageal Cancer Prevention - photo 1
Editors
Nabil F. Saba and Bassel F. El-Rayes
Esophageal Cancer
Prevention, Diagnosis and Therapy
2nd ed. 2020
Editors Nabil F Saba Hematology and Medical Oncology Emory University - photo 2
Editors
Nabil F. Saba
Hematology and Medical Oncology, Emory University Winship Cancer Institute, Atlanta, GA, USA
Bassel F. El-Rayes
Hematology and Medical Oncology, Emory University Winship Cancer Institute, Atlanta, GA, USA
ISBN 978-3-030-29831-9 e-ISBN 978-3-030-29832-6
https://doi.org/10.1007/978-3-030-29832-6
Springer Nature Switzerland AG 2020
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This Springer imprint is published by the registered company Springer Nature Switzerland AG

The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

In memory of Dr. Hanna Jean Khoury

To patients affected by esophageal cancer and their loved ones

Preface

Esophageal cancer is a major cause of cancer-related mortality worldwide. In the Western world, there has been a change in esophageal cancer presentation due to the rapidly rising incidence of distal esophageal adenocarcinoma. The heterogeneity of the disease and its aggressive clinical course has rendered the task of the development of an optimal multimodal management approach a challenging one. On the brighter side, there has been a noted surge in exploring novel therapeutic approaches in medical, surgical, and radiation therapy, including immune-based and targeted approaches, as well as palliative and nutritional supportive care.

Esophageal Cancer: Prevention, Diagnosis and Therapy,second edition, provides a unique and updated comprehensive review of the current epidemiology, molecular biology, staging, and treatment of cervical, thoracic, and junctional tumors. In addition, it highlights the differences in etiology, prognosis, and management of squamous cell and adenocarcinomas of the esophagus.

Promising novel diagnostic approaches and an in-depth review of cellular and molecular biology of premalignant lesions, the role of immunotherapy, as well as palliative and nutritional aspects are discussed in depth. We hope this second edition will further incite the interest of specialists from various diagnostic and therapeutic disciplines and will promote further research in the field of esophageal cancer.

Nabil F. Saba
Bassel F. El-Rayes
Atlanta, GA, USA
Acknowledgments

The editors acknowledge

Anthea Hammond for editorial contribution

Nefertiti Hawthorne for communication

Contents
Keshini Vijayan and Guy D. Eslick
Alfred K. Lam
Jessica Tracht , Brian S. Robinson and Alyssa M. Krasinskas
Adam Templeton , Andrew Kaz , Erik Snider and William M. Grady
Elizabeth G. Ratcliffe , Mohamed Shibeika , Andrew D. Higham and Janusz A. Jankowski
Thomas W. Rice and Eugene H. Blackstone
Valeria M. Moncayo , A. Tuba Kendi and David M. Schuster
Michelle P. Clermont and Field F. Willingham
Nassrene Elmadhun and Daniela Molena
Neil Bryan Newman and A. Bapsi Chakravarthy
Jarred P. Tanksley , Jordan A. Torok , Joseph K. Salama and Manisha Palta
Brandon Mahal and Theodore S. Hong
Megan Greally and David H. Ilson
Daniel H. Ahn and Tanios Bekaii-Saab
Megan Greally and Geoffrey Y. Ku
Baiwen Li , Shanshan Shen , Cicily T. Vachaparambil , Vladimir Lamm , Qunye Guan , Jie Tao , Hui Luo , Huimin Chen and Qiang Cai
Tiffany Barrett
Springer Nature Switzerland AG 2020
N. F. Saba, B. F. El-Rayes (eds.) Esophageal Cancer https://doi.org/10.1007/978-3-030-29832-6_1
1. Epidemiology and Risk Factors for Esophageal Cancer
Keshini Vijayan
(1)
The Whiteley-Martin Research Centre, The Discipline of Surgery, The University of Sydney, Sydney Medical School, Nepean Hospital, Penrith, NSW, Australia
Guy D. Eslick
Email:
Keywords
Epidemiology Risk factors Etiology Prevalence Incidence
Introduction
Esophageal cancer has a long and fascinating history and the epidemiology is geographically dynamic with wide variation from region to region []. There is an urgent need for cancer research organizations to provide increased and dedicated funding to gain a greater understanding of the dynamic epidemiology of esophageal cancer. This will be crucial to determine the causes and risk factors associated with developing this lethal cancer and, more importantly, form the cornerstone of developing any prevention strategies.
Fig 11 The incidence and mortality for all cancers note esophageal cancer - photo 3
Fig. 1.1

The incidence and mortality for all cancers, note esophageal cancer

Fig 12 Age-standardized incidence rates of esophageal cancer among males and - photo 4
Fig. 1.2

Age-standardized incidence rates of esophageal cancer among males and females globally (GLOBOCAN 2012)

There are two main histological types of esophageal cancer: adenocarcinoma and squamous cell carcinoma []. The epidemiology and risk factors for esophageal cancer vary substantially by these two different histological cell types. Published studies usually categorize esophageal cancer studies into either adenocarcinoma or squamous cell carcinoma histological types or a combined esophageal cancer grouping which contains both histological types.

Epidemiology
Incidence
Esophageal Adenocarcinoma

The global age-standardized incidence rate of esophageal adenocarcinoma (EAC) was estimated at 0.7 per 100,000 (1.1 in men and 0.3 in women) in 2012, with 52,000 estimated cases occurring during the year [].

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