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Edward C. Halperin MD - Perez & Bradys Principles and Practice of Radiation Oncology

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Inside the Sixth Edition of this now-classic reference, you will discover encyclopedic coverage of topics ranging from basic science to sophisticated computer-based radiation therapy treatment planning and supportive care. The books comprehensive scope and abundantly illustrated format provide you with better understanding of the natural history of cancer, the physical methods of radiation application, the effects of radiation on normal tissues, and the most judicious ways in which you can employ radiation therapy in patient care. Traditionally available as a printed textbook, now it comes with a completely revamped digital experience, powered by Inkling! NEW to the Sixth Edition Site-specific chapters include relevant background information on each tumorincluding epidemiology, pathology, diagnostic work-up, prognostic factors, treatment techniques, applications of surgery and chemotherapy, end results, and more. Over 1,400 full-color illustrations highlight key concepts in tumor pathogenesis, diagnosis, and targeted radiation therapy. Increased emphasis on new approaches and technologies improve your understanding of three-dimensional treatment planning, intensity-modulated radiotherapy, combined modality therapy, and particle therapy. Greater emphasis on palliative and supportive care reflects the role of radiation treatment in non-curative roles. New editors and contributors let you benefit from their decades of experience. Digital version includes the complete text, index-based search, note sharing, regular content updates integrated into the text, and much more. Improve outcomes for your patientsPick up your copy today!

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EDITORS
Edward C Halperin MD MA Chancellor for Health Affairs and Chief Executive - photo 1

Edward C. Halperin, MD, MA
Chancellor for Health Affairs and Chief Executive Officer
New York Medical College
Professor of Radiation Oncology, Pediatrics, and History
Provost for Biomedical Affairs
Touro College and University
Valhalla, New York

David E Wazer MD FASTRO Professor and Chairman Radiation - photo 2

David E. Wazer, MD, FASTRO
Professor and Chairman
Radiation Oncologist-in-Chief
Department of Radiation Oncology
Tufts Medical Center
Tufts University School of Medicine
Boston, Massachusetts
Rhode Island Hospital
Alpert Medical School of Brown University
Providence, Rhode Island

Carlos A Perez MD Professor Emeritus Mallinckrodt Institute of Radiology - photo 3

Carlos A. Perez, MD
Professor Emeritus
Mallinckrodt Institute of Radiology
Siteman Cancer Center
Washington University
St. Louis, Missouri

Luther W Brady MD Distinguished University Professor Hylda CohnAmerican - photo 4

Luther W. Brady, MD
Distinguished University Professor
Hylda Cohn/American Cancer Society Professor of Clinical Oncology
Professor, Department of Radiation Oncology
Drexel University College of Medicine
Philadelphia, Pennsylvania

PEREZ AND BRADYS
PRINCIPLES AND PRACTICE OF RADIATION ONCOLOGY
SIXTH EDITION

Senior Executive Editor Jonathan W Pine Jr Senior Product Manager Emilie - photo 5

Senior Executive Editor: Jonathan W. Pine, Jr.
Senior Product Manager: Emilie Moyer
Production Project Manager: David Orzechowski
Marketing Manager: Alexander Burns
Senior Designer: Stephen Druding
Production Service: Aptara, Inc.

2013 by LIPPINCOTT WILLIAMS & WILKINS, a WOLTERS KLUWER business
Two Commerce Square
2001 Market Street
Philadelphia, PA 19103 USA
LWW.com

First Edition copyright 1987 by J.B. Lippincott. Second Edition copyright 1992 by J.B. Lippincott. Third Edition copyright 1998 by Lippincott-Raven. Fourth Edition copyright 2004 by Lippincott Williams & Wilkins. Fifth Edition copyright 2008 by Lippincott Williams & Wilkins, a Wolters Kluwer business.

All rights reserved. This book is protected by copyright. No part of this book may be reproduced in any form by any means, including photocopying, or utilized by any information storage and retrieval system without written permission from the copyright owner, except for brief quotations embodied in critical articles and reviews. Materials appearing in this book prepared by individuals as part of their official duties as U.S. government employees are not covered by the above-mentioned copyright.

Printed in China

Library of Congress Cataloging-in-Publication Data
Perez and Bradys principles and practice of radiation oncology / editors, Edward C. Halperin [ et al.]. 6th ed.
p. ; cm.
Principles and practice of radiation oncology
Includes bibliographical references and index.
ISBN 978-1-4511-1648-9 (alk. paper)
I. Halperin, Edward C. II. Perez, Carlos A., 1934- III. Title: Principles and practice of radiation oncology.
[DNLM: 1. Neoplasmsradiotherapy. 2. Radiometry. 3. Radiotherapymethods. QZ 269]
RC271.R3
616.99'40642dc23

2012049568

Care has been taken to confirm the accuracy of the information presented and to describe generally accepted practices. However, the authors, editors, and publisher are not responsible for errors or omissions or for any consequences from application of the information in this book and make no warranty, expressed or implied, with respect to the currency, completeness, or accuracy of the contents of the publication. Application of the information in a particular situation remains the professional responsibility of the practitioner.
The authors, editors, and publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accordance with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new or infrequently employed drug.
Some drugs and medical devices presented in the publication have Food and Drug Administration (FDA) clearance for limited use in restricted research settings. It is the responsibility of the health care provider to ascertain the FDA status of each drug or device planned for use in their clinical practice.

To purchase additional copies of this book, call our customer service department at (800) 638-3030 or fax orders to (301) 223-2320. International customers should call (301) 223-2300.

Visit Lippincott Williams & Wilkins on the Internet: at LWW.com. Lippincott Williams & Wilkins customer service representatives are available from 8:30 am to 6 pm, EST.

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To our patients, who have taught us with their courage and suffering,

To our teachers, who inspired us with their knowledge and wisdom,

To our trainees, who will make tomorrow better than today,

To our families, who unselfishly endorsed our endeavors:

This book is gratefully dedicated.

Contributors

David J. Adelstein, MD

Professor of Medicine

Cleveland Clinic Lerner College of Medicine of Case Western Reserve University

Cleveland, Ohio

Anesa Ahamad, MD

Associate Lecturer

Faculty of Medical Sciences

University of the West Indies

St. Augustine, Trinidad Tobago

Kaled M. Alektiar, MD

Department of Radiation Oncology

Memorial Sloan Kettering Cancer Center

New York, New York

Robert J. Amdur, MD

Department of Radiation Oncology

College of Medicine

University of Florida

Gainesville, Florida

K. Kian Ang, MD, PhD

Professor

Department of Radiation Oncology

The University of Texas MD Anderson Cancer Center

Houston, Texas

Douglas W. Arthur, MD

Professor and Vice Chairman

Virginia Commonwealth University

VCU Massey Cancer Center

Richmond, Virginia

Elizabeth H. Baldini, MD, MPH

Associate Professor

Harvard Medical School

Radiation Oncology Director

Bone and Soft Tissue Sarcoma Program

Dana-Farber Cancer Institute and Brigham and Womens Hospital

Boston, Massachusetts

Michael Baumann, MD

Medical Faculty and University Hospital Carl Gustav Carus

Department of Radiation Oncology and OncoRay

National Center for Radiation Research in Oncology Dresden

Technical University of Dresden

Dresden, Germany

Jose G. Bazan, MD, MS

Resident, Department of Radiation Oncology

Stanford Cancer Center

Stanford, California

Stanley Benedict, PhD

Director, Radiological Physics

Department of Radiation Oncology

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