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Michael J. Campbell - Statistics at Square Two

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Michael J. Campbell Statistics at Square Two

Statistics at Square Two: summary, description and annotation

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STATISTICS AT SQUARE TWO

An easy-to-follow exploration of intermediate statistical techniques used in medical research

In the newly revised third edition of Statistics at Square Two: Understanding Modern Statistical Applications in Medicine, a team of distinguished statisticians delivers an accessible and intuitive discussion of advanced statistical methods for readers and users of scientific medical literature. This will allow readers to engage critically with modern research as the authors explain the correct interpretation of results in the medical literature.

The book includes two brand new chapters covering meta-analysis and time-series analysis as well as new references to the many checklists that have appeared in recent years to enable better reporting of contemporary research. Most examples have been updated as well, and each chapter contains practice exercises and answers. Readers will also find sample code (in R) for many of the analyses, in addition to:

  • A thorough introduction to models and data, including the different types of data, statistical models, and computer-intensive methods
  • Comprehensive explorations of multiple linear regression, including the interpretation of computer output, diagnostic statistics such as influential points, and many uses of multiple regression
  • Practical discussions of multiple logistic regression, survival analysis, Poisson regression and random effects models including their uses, examples in the medical literature, and strategies for interpreting computer output

Perfect for anyone hoping to better understand the statistics presented in contemporary medical research, Statistics at Square Two: Understanding Modern Statistical Applications in Medicine will also benefit postgraduate students studying statistics and medicine.

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Appendix 1 Exponentials and Logarithms It is simple to understand raising a - photo 1
Appendix 1
Exponentials and Logarithms

It is simple to understand raising a quantity to a power, so that: Statistics at Square Two - image 2 is equivalent to: Statistics at Square Two - image 3 . This can be generalised to: Statistics at Square Two - image 4 for arbitrary n so Statistics at Square Two - image 5n times.

A simple result is that:

Statistics at Square Two - image 6 (A1.1)

for arbitrary n and m. Thus, for example 32 34 = 36 = 729. It can be shown that this holds for any values of m and n, not just whole numbers.

We define: because A useful extension of the concept of powers is to let n take - photo 7 , because: A useful extension of the concept of powers is to let n take fractional or - photo 8 .

A useful extension of the concept of powers is to let n take fractional or negative values. Thus: Statistics at Square Two - image 9 can be shown to be equivalent to: Statistics at Square Two - image 10 , because: Statistics at Square Two - image 11 and also: Statistics at Square Two - image 12 .

Also: Statistics at Square Two - image 13 can be shown equivalent to 1/x, because: Statistics at Square Two - image 14 .

If Picture 15 , then the definition of a logarithm of y to the base x is the power that x has to be raised to get y. This is written: Picture 16 or n equals log to the base x of y.

Suppose and It can be shown from Equation A11 that Thus when we multiply two - photo 17 and It can be shown from Equation A11 that Thus when we multiply two - photo 18 . It can be shown from Equation A1.1 that:

Thus when we multiply two numbers we add their logs This was the basis of the - photo 19

Thus, when we multiply two numbers we add their logs. This was the basis of the original use of logarithms in that they enabled a transformation whereby arithmetic using multiplications could be done using additions, which are much easier to do by hand. In Appendix 2 we need an equivalent result, namely that:

Statistics at Square Two - image 20

In other words, when we log transform the ratio of two numbers we subtract the logs of the two numbers.

The two most common bases are 10, and a strange quantity: e = 2.718, where the dots indicate that the decimals go on indefinitely. This number e has the useful property that the slope of the curve: Picture 21 at any point (x, y) is just y, whereas for all other bases the slope is proportional to y but not exactly equal to it. The formula: Picture 22 is often written: Picture 23 . The logarithms to base e and 10 are often denoted ln and log respectively on calculators, and log and log10 in R. Logs to base e are often called the natural logarithm. In this book all logarithms are natural, that is to base e. We can get from one base to the other by noting that: Statistics at Square Two - image 24 . To find the value of e in R use the fact that: Statistics at Square Two - image 25 , thus:

> e<- exp(1)> e[1] 2.718282To find log10(e):> log10(e)[1] 0.4342945

Thus: Statistics at Square Two - image 26 .

Note, log is just the inverse function to exponential so: Picture 27 .

For example if x = 23:

> exp(log(23))[1] 23

Note, it follows from the definition that for any: Picture 28 , Picture 29 .

In this book exponentials and logarithms feature in a number of places. It is much easier to model data as additive terms in a linear predictor and yet often terms, such as risk, behave multiplicatively, as discussed in . The line does not plateau, but the rate of increase gets smaller as x increases.

Logex vs x Appendix 2 Maximum Likelihood and Significance Tests Summary - photo 30

Loge(x) vs x.

Appendix 2
Maximum Likelihood and Significance Tests
Summary

This appendix gives a brief introduction to the use of maximum likelihood, which was the method used to fit the models in the earlier chapters. We describe the Wald test and the likelihood ratio (LR) test and link the latter to the deviance. Further details are given in Clayton and Hills.

A2.1Binomial Models and Likelihood

A model is a structure for describing data and consists of two parts. The first part describes how the explanatory variables are combined in a linear fashion to give a linear predictor. This is then transformed by a function known as a link function to give predicted or fitted values of the outcome variable for an individual. The second part of the model describes the probability distribution of the outcome variable about the predicted value.

Perhaps the simplest model is the Binomial model. An event happens with a probability . Suppose the event is the probability of giving birth to a boy and suppose we had five expectant mothers who subsequently gave birth to two boys and three girls. The boys were born to mothers numbered 1 and 3. If is the probability of a boy the probability of this sequence of events occurring is (1 ) (1 ) (1 ). If the mothers had different characteristics, say their age, we might wish to distinguish them and write the probability of a boy for mother

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