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Michael E. Edmonds - Limb Salvage of the Diabetic Foot: An Interdisciplinary Approach

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Michael E. Edmonds Limb Salvage of the Diabetic Foot: An Interdisciplinary Approach
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This book provides a practical guide to the treatment of patients as risk from limb amputation. The most common presentations of the diabetic foot are presented in concise and evidence-based chapters covering the neuropathic foot, the Charcot foot, the ischemic foot, and the infected foot. Each section includes an introduction to the clinical approach as well as an algorithm illustrating the limb salvage pathway and intervention steps. Limb Salvage of the Diabetic Foot: An Interdisciplinary Approach aims to help the reader build an interdisciplinary understanding of the diabetic foot and its treatment and is of interest to all members of the interdisciplinary diabetic foot team including surgeons, podiatrists, radiologists, nurses, orthotists, infectious disease physicians, and endocrinologists.

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Editors Michael E Edmonds and Bauer E Sumpio Limb Salvage of the Diabetic - photo 1
Editors
Michael E. Edmonds and Bauer E. Sumpio
Limb Salvage of the Diabetic Foot
An Interdisciplinary Approach
Editors Michael E Edmonds Kings College Hospital London UK Bauer E - photo 2
Editors
Michael E. Edmonds
Kings College Hospital, London, UK
Bauer E. Sumpio
School of Medicine, Yale University, New Haven, CT, USA
ISBN 978-3-319-17917-9 e-ISBN 978-3-319-17918-6
https://doi.org/10.1007/978-3-319-17918-6
The use and dosages of medicines stated in the book are advisory and should be checked by the individual prescriber.
Springer Nature Switzerland AG 2019
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.
The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This Springer imprint is published by the registered company Springer Nature Switzerland AG.

The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

This book is dedicated to our families, for their unconditional love and support.

Preface

The prevalence of diabetes continues to increase worldwide and coincides with a progressive increase in the number of diabetic foot complications. A major amputation in a patient with diabetes takes place every 20 s throughout the world. It is said that 80% of amputations in diabetic patients are preventable. This book is devoted to limb salvage and is about saving the limbs and lives of diabetic foot patients.

After an introductory chapter on assessment, classification and approach to management, the book is divided into four sections, devoted to the four commonest presentations of the diabetic foot, namely, the neuropathic foot, the Charcot foot, the ischaemic foot and the infected foot. Each section has an introduction explaining the clinical approach to each of the presentations and is accompanied by an algorithm illustrating the limb salvage pathway and intervention steps for each of the four presentations. Each section contains clinical photographs illustrating the various presentations as well as the techniques of management.

This book emphasizes the need for an interdisciplinary team approach to the diabetic foot and should help individual members of the team to understand the differing roles of other members. The team is usually referred to as the interdisciplinary team, although in this book, the term multidisciplinary team is also used. There may be subtle differences in the meaning of these terms, but in this multi-author book, they are regarded as interchangeable.

This book is a collaboration between members of the interdisciplinary diabetic foot teams of Kings College Hospital, London, and Yale University School of Medicine, New Haven. This collaboration started in October 2015 with a joint Yale-King's Vascular Symposium at Kings College Hospital, which has been followed by two further symposia, at Yale and in Thailand, the latter in conjunction with the Thai Vascular Association. Contributors to these symposia, from Yale and Kings, form the authorship of this book. We are grateful to them for agreeing to share their expertise in this book.

Finally, we wish to thank our developmental editors, Barbara Lopez-Lucio and Joni Fraser, for their excellent assistance and patience which have been much appreciated.

We hope this book will improve the outlook of the patient with diabetic foot problems and reduce the number of avoidable major amputations.

Michael E. Edmonds
Bauer E. Sumpio
London, UK New Haven, CT
Abbreviations
ABI

Ankle brachial index

ACC

American College of Cardiology

ADA

American Diabetes Association

AFO

Ankle foot orthosis

AFS

Amputation-free survival

AHA

American Heart Association

ALADIN III study

Alpha lipoic acid in diabetic neuropathy III study

AMWT

Advanced moist wound therapy

AOFAS

Academy of Foot and Ankle Surgeons

AP

Antero-posterior

ARI

Aldose reductase inhibitors

ATA

Anterior tibial artery

AVF

Arteriovenous fistula

BASIL

Bypass versus Angioplasty in Severe Ischaemia of the Leg

BIS

Bispectral index

BMI

Body mass index

BMS

Bare-metal stent

BTA

Below the ankle

BTK

Below the knee

CAD

Computer-aided design

CAM

Computer-aided manufacture

CA-MRSA

Community-acquired methicillin-resistant Staphylococcus aureus

CAN

Cardiac autonomic neuropathy

CART

Controlled antegrade and retrograde subintimal tracking

CCO

Clostridial collagenase ointment

CE MRA

Contrast enhanced magnetic resonance angiography

CFA

Common femoral artery

CHF

Congestive heart failure

cFN

Cellular fibronectin

CGRP

Calcitonin gene-related peptide

CI

Confidence interval

CIDP

Chronic inflammatory demyelinating polyneuropathy

CHF

Congestive heart failure

CKD

Chronic kidney disease

CLI

Critical limb ischaemia

CLTI

Chronic Limb Threatening Ischaemia

CN

Charcot neuroarthropathy

CoNS

Coagulase negative Staphylococci

CPA

Complete pedal arch

CPE

Carbapenamase-producing Enterobacteriaceae

CRE

Carbapenem-resistant Enterobacteriaceae

CROW

Charcot restraint orthotic walker

CRN

Contrast related nephrotoxicity

CRP

C-reactive protein

CT

Computed tomography

CTA

Computed tomography angiography

CTO

Chronic total occlusion

CWD

Continuous-wave Doppler

DAFNE

Dose Adjustment for Normal Eating

DAN

Diabetic autonomic neuropathy

DCB

Drug-coated balloons

DCCT

Diabetes Control and Complications Trial

DE-CTA

Dual Energy-CTA

DES

Drug- eluting stent

DFC

Diabetic Foot Clinic

DFI

Diabetic foot infection

DFO

Diabetic foot osteomyelitis

DFU

Diabetic foot ulcer

dHACM

dehydrated human amnion/chorion membrane

DIPJ

Distal interphalangeal joint

DN

Diabetic neuropathy

DP

Dorso-plantar

DPA

Dorsalis pedis artery

DPPN

Diabetic painful peripheral neuropathy

DR

Direct revascularization

DSA

Digital subtraction angiography

DSPN

Diabetic sensorimotor peripheral neuropathy

DUS

Duplex ultrasound

ECM

Extracellular matrix

EDB

Extensor digitorum brevis

eGFR

Estimated glomerular filtration rate

EPS

Extracellular polymeric substance

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