U Satyanarayana - Biochemistry

Biochemistry, 4e

Satyanarayana and Chakrapani

ELSEVIER

A division of Reed Elsevier India Private Limited

Mosby, Saunders, Churchill Livingstone, Butterworth-Heinemann and Hanley & Belfus are the Health Science imprints of Elsevier.

2013 Dr. U. Satyanarayana

First Published: March 1999

Revised Reprint: August 2000

Second Revised Edition: June 2002

Revised Reprint: 2004, 2005

Third Revised Edition (multicolour): 2006

Revised Reprint: 2007, 2010

Fourth Revised Edition: 2013

All rights are reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise without the prior permission of the publishers.

ISBN: 978-81-312-3601-7

Medical knowledge is constantly changing. As new information becomes available, changes in treatment, procedures, equipment and the use of drugs become necessary. The author, editors, contributors and the publisher have, as far as it is possible, taken care to ensure that the information given in this text is accurate and up-to-date. However, readers are strongly advised to confirm that the information, especially with regard to drug dose/usage, complies with current legislation and standards of practice. Please consult full prescribing information before issuing prescriptions for any product mentioned in this publication.

This edition of Biochemistry, 4e by Dr. U. Satyanarayana and Dr. U. Chakrapani is co-published by an arrangement with Elsevier, a division of Reed Elsevier India Private Limited and Books and Allied (P) Ltd.

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Cover Design

Depicts the universal energy currency of the living worldATP, predominantly synthesized by the mitochondria of the cell (the functional unit of life), in comparison with the international currencies$, , ,,.

Preface to the Fourth Edition

This book Biochemistry has undoubtedly become one of the most preferred text books (in India and many other countries) by the students as well as teachers in medical, biological and other allied sciences. It is certainly a book of choice and a true companion to all learning biochemistry, hence appropriately regarded by many as Bible of Biochemistry. This book has undergone three editions, several reprints, and revised reprints in a span of 13 years.

The advances in biochemistry are evergrowing due to exponential growth of the subject. Further, the critical comments, frank opinions and constructive suggestions by teachers and students need to be seriously considered. All this necessitates frequent revision of the book.

In this fourth edition, a thorough revision and update of each chapter with latest advances has been done. The main emphasis of this edition is an improved orientation and treatment of human biochemistry in health and disease. A wide variety of case studies with relevant biochemical profiles (along with diagnosis and discussion) are newly added as an appendix. In addition, several newer aspects of biochemistry are covered in this edition, some of them are listed below.

It is a fact that I represent a selected group of individuals authoring books, having some time at disposal, besides hard work, determination and dedication. I consider myself as an eternal reader and a regular student of biochemistry. However, it is beyond my capability to keep track of the evergrowing advances in biochemistry due to exponential growth of the subject. And, this makes me nervous whenever I think of revising the book. I honestly and frankly admit that I have to depend on mature readers for subsequent editions of this book.

An invitation to readers, well wishers and subject experts

) expressing their frank opinions, critical comments and constructive suggestions. And this will help me to further improve the book in subsequent revisions.

Dr. U. Satyanarayana

Preface to the First Edition

Biochemistry is perhaps the most fascinating subject as it deals with the chemical language of life, be it human, animal, plant or microorganism. No other science subject has as much application as biochemistry to the disciplines of medicine, health, veterinary, agriculture bioengineering and technology. This necessitates a totally different outlook for the books on biochemistry subject.

There are many biochemistry textbooks on the market. Some of them are purely basic while others are applied, and there are very few books which cover both these aspects together. For this reason, the students learning biochemistry in their undergraduate courses have to depend on multiple books to acquire a sound knowledge of the subject.

This book, Biochemistry is unique with a simultaneous and equal emphasis on basic and applied aspects of biochemistry. This textbook primarily is an integration of medical and pure sciences, comprehensively written to meet the curriculum requirements of undergraduate courses in medical, dental, pharmacy, life-sciences and other categories (agriculture, veterinary, etc.) where students learn biochemistry as one of the subjects.